Search

Displaying results 81 - 90 of 93 in total
  1. Target

    Tyrosine-protein kinase Fes/Fps

    go.drugbank.com/bio_entities/BE0009444
    TargetHumans

    Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.

  2. Target

    B-cell receptor CD22

    go.drugbank.com/bio_entities/BE0000183
    TargetHumans

    Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking

  3. Target

    Interleukin-2

    go.drugbank.com/bio_entities/BE0001029
    TargetHumans

    Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production (PubMed:6438535).

  4. Target

    Tyrosine-protein kinase Fyn

    go.drugbank.com/bio_entities/BE0000839
    TargetHumans

    In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798)

  5. Target

    Tyrosine-protein kinase Fer

    go.drugbank.com/bio_entities/BE0009443
    TargetHumans

    Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.

  6. Target

    Tumor necrosis factor receptor superfamily member 5

    go.drugbank.com/bio_entities/BE0001196
    TargetHumans

    Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

  7. Target

    DNA polymerase theta

    go.drugbank.com/bio_entities/BE0010760
    TargetHumans

    Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity).

  8. Target

    POU domain, class 2, transcription factor 1

    go.drugbank.com/bio_entities/BE0009712
    TransporterHumans

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins

  9. Target

    Histone-lysine N-methyltransferase NSD2

    go.drugbank.com/bio_entities/BE0012398
    TargetHumans

    Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity).

  10. Target

    Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

    go.drugbank.com/bio_entities/BE0021514
    EnzymeHumans

    Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity)