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Hydroxyproline dehydrogenase
go.drugbank.com/bio_entities/BE0020644EnzymeHumansDoes not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. … Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor.
Synonyms: Kidney and liver proline oxidase 1Potassium channel subfamily T member 2
go.drugbank.com/bio_entities/BE0015626TargetHumansContributes to regulate neuronal excitability (PubMed:29069600) … Sodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868).
Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1, Sequence like an intermediate conductance potassium channel subunitCyanocobalamin reductase / alkylcobalamin dealkylase
go.drugbank.com/bio_entities/BE0002175TargetHumansto shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). … Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and
Synonyms: Methylmalonic aciduria and homocystinuria type C proteinVesicular inhibitory amino acid transporter
go.drugbank.com/bio_entities/BE0002308TransporterHumansThe transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). … Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals.
Synonyms: GABA and glycine transporterAll-trans-retinol 13,14-reductase
go.drugbank.com/bio_entities/BE0002320TargetHumansCatalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers.
Synonyms: PPAR-alpha-regulated and starvation-induced gene proteinComplement C4-A
go.drugbank.com/bio_entities/BE0004685TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2Complement C4-B
go.drugbank.com/bio_entities/BE0004686TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
go.drugbank.com/bio_entities/BE0000525TargetHumansMay play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091) … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
Synonyms: Gene associated with retinoic and IFN-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 proteinZinc transporter ZIP10
go.drugbank.com/bio_entities/BE0009884TransporterHumansWhen associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). … Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity).
Synonyms: Zrt- and Irt-like protein 10RNA-splicing ligase RTCB
go.drugbank.com/bio_entities/BE0004442TargetHumansThe covalently bound GMP is then transferred to this 3' phosphate to form an RNA(3')-P-P-(5')G intermediate. … The first step requires ZBTB8OS/Archease and involves the guanylylation of RTCB at its active site histidine, forming a covalent GMP-histidine intermediate.
Synonyms: RNA 2',3'-cyclic phosphate and 5'-OH ligase