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Displaying results 81 - 90 of 100 in total
  1. Target

    Protein arginine N-methyltransferase 1

    go.drugbank.com/bio_entities/BE0004597
    TargetHumans

    Methylates NPRL2 at 'Arg-78' leading to inhibition of its GTPase activator activity and then the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions

  2. Target

    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    go.drugbank.com/bio_entities/BE0008997
    TargetHumans

    S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs.

  3. Target

    Translation initiation factor eIF2B subunit beta

    go.drugbank.com/bio_entities/BE0013252
    TargetHumans

    Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available

  4. Target

    C-8 sterol isomerase ERG2

    go.drugbank.com/bio_entities/BE0027702
    TargetBaker's yeast

    Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.

  5. Target

    Serine hydroxymethyltransferase, cytosolic

    go.drugbank.com/bio_entities/BE0000331
    TargetHumans

    conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF, serving as a critical component of the folate cycle and facilitating one-carbon biosynthetic reactions essential for methionine

  6. Target

    Glycine N-methyltransferase

    go.drugbank.com/bio_entities/BE0000372
    TargetEnzymeHumans

    Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine

  7. Target

    Propionyl-CoA carboxylase alpha chain, mitochondrial

    go.drugbank.com/bio_entities/BE0000492
    TargetHumans

    the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine

  8. Target

    Cystathionine gamma-lyase

    go.drugbank.com/bio_entities/BE0000791
    TargetEnzymeHumans

    Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into

  9. Target

    S-methyl-5'-thioadenosine phosphorylase

    go.drugbank.com/bio_entities/BE0001128
    TargetHumans

    Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine (PubMed:3091600, PubMed:8687427, PubMed:10404592).

  10. Target

    Serine hydroxymethyltransferase

    go.drugbank.com/bio_entities/BE0001838
    TargetShigella flexneri

    This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.