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Cocaine Action Pathway
smpdb.ca/view/SMP0000395Drug actionCocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and...
Dibucaine Action Pathway
smpdb.ca/view/SMP0000396Drug actionDibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...
Levobupivacaine Action Pathway
smpdb.ca/view/SMP0000397Drug actionLevobupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Levobupivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it i...
Oxybuprocaine Action Pathway
smpdb.ca/view/SMP0000400Drug actionOxybuprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Oxybuprocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is pr...
Procaine Action Pathway
smpdb.ca/view/SMP0000402Drug actionProcaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Procaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated a...
Hydromorphone Action Pathway
smpdb.ca/view/SMP0000410Drug actionHydromorphone (also known as dihydromorphinone or Dilaudid) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of int...
Hydrocodone Action Pathway
smpdb.ca/view/SMP0000411Drug actionHydrocodone (also known as Vicodin or Norco) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAMP...
Alfentanil Action Pathway
smpdb.ca/view/SMP0000413Drug actionAlfentanil (also known as Alfenta or Rapifen) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAM...
Sufentanil Action Pathway
smpdb.ca/view/SMP0000417Drug actionSufentanil is a pharmacologically-active synthetic small molecule derived from fentanyl and belongs to a class of drugs called opioids. Opioids are therapeutically employed to achieve analgesia. Sufentanil’s rapid mechanism of action pri...
Escitalopram Action Pathway
smpdb.ca/view/SMP0000425Drug actionEscitalopram is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depen...