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Oxamniquine
go.drugbank.com/drugs/DB01096ApprovedOxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. … An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingCephalexin
go.drugbank.com/drugs/DB00567ApprovedInvestigationalVet approved[A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971. … Cephalexin is the first of the first generation cephalosporins.[A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide.
Synonyms: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acidInternational brands: L-Keflex3-oxoacyl-[acyl-carrier-protein] synthase 1
go.drugbank.com/bio_entities/BE0000801TargetEscherichia coli (strain K12)Can also use unsaturated fatty acids (PubMed:19679654, PubMed:3076377, PubMed:8910376). … Has an absolute requirement for an ACP substrate as the acyl donor, and no activity is detected when both substrates are based on CoA (PubMed:22017312).
Synonyms: KAS I, Beta-ketoacyl-ACP synthase IAluminum zirconium tetrachlorohydrex gly
go.drugbank.com/drugs/DB11149ApprovedWithdrawnAluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent. … Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.
Mixtures: Ban Ultra Antiperspirant Roll-ONProducts: Ban U. Fr. & Dry Wo Ap Roll-ON W Aloe-skiing, No Name Ladies Antip 23% Sport ScentProtein-arginine deiminase type-1
go.drugbank.com/bio_entities/BE0002314TargetHumansCatalyzes the deimination of arginine residues of proteins
Synonyms: Peptidylarginine deiminase I, Protein-arginine deiminase type ILymphoma, Diffuse
go.drugbank.com/conditions/DBCOND0036855Synonyms: Non-Hodgkin lymphoma, no ICD-O subtype, Non-Hodgkin lymphoma, no ICD-O subtype (morphologic abnormality)Cholesteryl ester transfer protein
go.drugbank.com/bio_entities/BE0003516TargetHumansInvolved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density ...
Synonyms: Lipid transfer protein IFenproporex
go.drugbank.com/drugs/DB01550ApprovedIllicitWithdrawnIn 2006 and 2009, the FDA issued warnings that it had been detected in diet pills sold online, and imported from foreign manufacturers. … It is listed as an illicit substance in many countries due to addiction issues and listed as a prohibited substance by the World Anti-Doping Agency.
International brands: Desobesi-MProducts: IFA-DIETY A. P.Noncanonical Wnt/Ca2+ signaling
smpdb.ca/view/SMP0468891SignalingThe Wnt/Ca²⁺ pathway is activated by the binding of the Wnt ligand to a Frizzled receptor.
3-dehydroquinate dehydratase
go.drugbank.com/bio_entities/BE0001819TargetSalmonella typhiInvolved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-d...
Synonyms: Type I DHQase, Type I dehydroquinase