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Displaying results 921 - 930 of 10000 in total
  1. Pathway

    Intracellular Signalling Through PGD2 receptor and Prostaglandin D2

    smpdb.ca/view/SMP0000343
    Signaling

    The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream

    Drugs: ATP · Magnesium cation · Prostaglandin D2 · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Prostaglandin D2 receptor
  2. Drug

    Receptor binding domain (RBD) SARS-CoV-2 (COVID-19) hepatitis B surface antigen (HBsAg) virus-like particle (VLP) vaccine

    go.drugbank.com/drugs/DB16431
    Experimental

    Receptor binding domain SARS-CoV-2 Hepatitis B surface antigen virus-like particle vaccine (RBD SARS-CoV-2 HBsAg VLP vaccine), is a virus-like particle vaccine candidate where the RBD antigen is conjugated … Regarding this vaccine specifically, it stimulates the immune system to produce anti-receptor binding domain antibodies[A226593].

  3. Drug

    Mapatumumab

    go.drugbank.com/drugs/DB18945
    Investigational

    Mapatumumab is under investigation in clinical trial NCT00094848 (Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-hodgkin's Lymphoma (NHL)).

    Synonyms: Immunoglobulin g1, anti-(human cytokine receptor dr4 (death receptor 4)) (human monoclonal trm-1 heavy chain), disulfide with human monoclonal trm-1 .lambda.-chain, dimer, Immunoglobulin g1, anti-(human cytokine receptor dr4 (death receceptor 4)) (human monoclonal trm-1 heavy chain), disulfide with human monoclonal trm-1 .lambda.-chain, dimer
  4. Drug

    Tomaralimab

    go.drugbank.com/drugs/DB15415
    Investigational

    Tomaralimab is under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function).

    Synonyms: Humanized IGG4 monoclonal antibody against toll-like receptor 2 for prevention of ischemia/reperfusion tissue injury
  5. Target

    3-hydroxyacyl-CoA dehydrogenase type-2

    go.drugbank.com/bio_entities/BE0000317
    TargetEnzymeHumans

    Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubM...

    Synonyms: 17-beta-estradiol 17-dehydrogenase
  6. Indication

    Herpes Zoster

    go.drugbank.com/conditions/DBCOND0028191
    Drugs: Acyclovir · Brivudine · Econazole · Famciclovir · Lysozyme · Ox bile extract +3 more
    Synonyms: Zoster [herpes zoster], Zoster
  7. Pathway

    Androgen and Estrogen Metabolism

    smpdb.ca/view/SMP0000068
    Metabolic

    This pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  8. Pathway

    17-beta Hydroxysteroid Dehydrogenase III Deficiency

    smpdb.ca/view/SMP0000356
    Disease

    17-beta hydroxysteroid dehydrogenase III deficiency, also known as 17-KSR deficiency or male pseudohermaphroditism with gynecomastia (MPH), is as rare inborn error of metabolism (IEM) and autosomal recessive disorder of the androgen and ...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  9. Pathway

    Aromatase Deficiency

    smpdb.ca/view/SMP0125782
    Disease

    Aromatase deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of mutations in the CYP19A1 gene. The CYP19A1 gene encodes for the enzyme aromatase. Aromatase converts androgens to estrogens which is vita...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  10. Drug

    Lumiliximab

    go.drugbank.com/drugs/DB06162
    Investigational

    Lumiliximab is a chimeric monoclonal antibody which is used as an immunosuppressive drug. … It is a primatized anti-CD23 macaque/human chimeric antibody that inhibits the production of the IgE antibody, for the potential treatment of allergic conditions.

    Synonyms: IMMUNOGLOBULIN G1, ANTI-(HUMAN IMMUNOGLOBULIN E RECEPTOR TYPE II) (HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .KAPPA.-CHAIN, DIMER, IMMUNOGLOBULIN G1, ANTI-(HUMAN IMMUNOGLOBULIN E RECEPTOR TYPE II) (HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .GAMMA.1-CHAIN), DISULPHIDE WITH HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .KAPPA.-CHAIN, DIMER