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Iloprost Action Pathway
smpdb.ca/view/SMP0126507Drug actionIloprost is a prostacyclin analog also known as Ventavis, that acts to prevent platelet aggregation. It is a second-generation analog that is structurally similar to prostacyclin. It binds to prostacyclin receptors that activate adenylyl...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Bimatoprost Action Pathway
smpdb.ca/view/SMP0127009Drug actionBimatoprost is a prostaglandin analog with multiple medical applications. It belongs to the prostamide group of drugs and is available in both ophthalmic solution and implant forms. Primarily, bimatoprost is used to manage elevated intra...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Dinoprostone Action Pathway
smpdb.ca/view/SMP0127013Drug actionDinoprostone is a naturally occurring prostaglandin E2 (PGE2) with significant roles in various physiological processes, most notably in labor. This medication, available as a vaginal suppository, is used for several medical purposes. Fi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Cardiovascular Mortality
go.drugbank.com/conditions/DBCOND0040959Drugs: Acetylsalicylic acid · Canagliflozin · Colchicine · Dapagliflozin · Empagliflozin · Evolocumab +12 moreDimetacrine
go.drugbank.com/drugs/DB08996ApprovedWithdrawnDimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe for the treatment of depression. Dimetacrine is no longer used in Japan. … Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil.
Categories: Heterocyclic Compounds, 3-RingSynonyms: 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amineGlutathione Metabolism
smpdb.ca/view/SMP0000015MetabolicGlutathione (GSH) is an low-molecular-weight thiol and antioxidant in various species such as plants, mammals and microbes. Glutathione plays important roles in nutrient metabolism, gene expression, etc. and sufficient protein nutrition ...
Enzymes: Glutathione S-transferase omega-25-Oxoprolinase Deficiency
smpdb.ca/view/SMP0000500Disease5-Oxoprolinase deficiency, also called OPLAHD, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glutathione metabolism caused by a defective 5-oxoprolinase. 5-Oxoprolinase catalyzes the conversion of 5-oxopr...
Enzymes: Glutathione S-transferase omega-2gamma-Glutamyltranspeptidase Deficiency
smpdb.ca/view/SMP0000501DiseaseGamma-glutamyltranspeptidase deficiency, characterized by glutathionemia and glutathionuria, is an autosomal recessive disorder of glutathione metabolism caused by a defective gamma-glutamyl transpeptidase (GGT). GGT transfers glutamyl m...
Enzymes: Glutathione S-transferase omega-2Glutathione Synthetase Deficiency
smpdb.ca/view/SMP0125614DiseaseGlutathione Synthetase Deficiency (5-Oxoprolinuria; Pyroglutamic Aciduria; GSD) is a rare inborn error of metabolism (IEM) which arises from a disfunctional gene called GSS. This gene is responsible for glutathione synthetase. Glutathion...
Enzymes: Glutathione S-transferase omega-2gamma-Glutamyltransferase Deficiency
smpdb.ca/view/SMP0125616DiseaseGamma-Glutamyltransferase Deficiency is an autosomal recessive disorder caused by a mutation in the GGT1 gene which codes for gamma-glutamyltranspeptidase 1. A deficiency in this enzyme results in accumulation of L-cysteine, gamma-glutam...
Enzymes: Glutathione S-transferase omega-2