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Brilliant blue G Drug Metabolism
smpdb.ca/view/SMP0130733MetabolicBrilliant blue G passes through the liver and is then excreted from the body mainly through the kidney. … Brilliant blue G is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Brilliant blue GTriflusal Action Pathway
smpdb.ca/view/SMP0126548Drug actionTrifusal binds to the prostaglandin G/H synthase 1, this inhibits the production of thromboxane-B2 in cells.
Enzymes: Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2Dipyridamole Action Pathway
smpdb.ca/view/SMP0122804Drug actionArachidonic acid produces prostaglandin H2 via prostaglandin G/H synthase 1 & 2. Thromboxane A2 is then formed from prostaglandin H2 via thromboxane A synthase.
Enzymes: Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb.ca/view/SMP0000321SignalingThe adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortDipyridamole Phosphodiesterase Action Pathway
smpdb.ca/view/SMP0126489Drug actionDipyridamole is a phosphodiesterase inhibitor also known as Aggrenox and Persantine, used to prevent thromboembolic events post-operation. Routes of administration fall under intravenous or oral administration. Dipyridamole inhibits aden...
Enzymes: Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortRegulation of Lipolysis
smpdb.ca/view/SMP0573273SignalingAdipocyte lipolysis is a highly regulated metabolic process in which triacylglycerols stored in lipid droplets are enzymatically hydrolyzed to free fatty acids and glycerol to meet systemic energy demands. This multistep cascade is orche...
Enzymes: Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2Purine Nucleoside Phosphorylase Deficiency
smpdb.ca/view/SMP0125728DiseasePurine nucleoside phosphorylase deficiency (Nucleoside phosphorylase; Immunodeficiency) is a rare disease causing severe immunodeficiency. The disease is caused by a mutation in the enzyme purine nucleoside phosphorylase. The enzyme is n...
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreEnzymes: ATP-binding cassette sub-family G member 2Gout or Kelley-Seegmiller Syndrome
smpdb.ca/view/SMP0125723DiseaseGout, also called Kelley-Seegmiller syndrome, is a condition that is hereditary and causes an excess in the production of uric acid in the body. It is caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase. W...
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreEnzymes: ATP-binding cassette sub-family G member 2Betaine Metabolism
smpdb.ca/view/SMP0000123MetabolicBetaine (or trimethylglycine) is similar to choline (trimethylaminoethanol) but differs in choline's terminal carboxylic acid group trimethylglycine is reduced to a hydroxyl group. Betaine is obtained from diet as betaine or compounds co...