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Antihemophilic Factor Human Recombinant Action Pathway
smpdb.ca/view/SMP0126774Drug actionAntihemophilic factor, human recombinant is administered intravenously and acts to correct coagulation defects, by activating coagulation factor X and IX. … Antihemophilic factor, human recombinant of the coagulation Factor VIII, also known as Advate, Adynovate, Helixate, Kogenate, Kovaltry, Novoeight, Recombinate, to treat hemophilia A, von Willebrand disease
Enzymes: Coagulation factor IX, Coagulation factor VIIICoagulation Factor VII Human Action Pathway
smpdb.ca/view/SMP0126839Drug actionCoagulation factor VII human is a coagulation factor also known as Balfaxar, Beriplex, Kcentra and Octaplex to treat hemophilia and Glanzmann's thrombasthenia. … It is administered intravenously it acts in combination with tissue factor activating coagulation factor VIIa, which goes on to subsequently activate coagulation factor X and IX leading to blood clotting
Enzymes: Coagulation factor IX, Coagulation factor VIIIAntihemophilic Factor Human Action Pathway
smpdb.ca/view/SMP0126841Drug actionAdministered intravenously the antihemophilic factor human replaces the abnormal coagulation factor VIII, acting as a cofactor to activate coagulation factor IX and X. … It is a non-recombinant concentrate of the endogenous coagulation factor VIII, produced by reducing von Willebrand Factor antigen and purified by affinity chromatography.
Enzymes: Coagulation factor IX, Coagulation factor VIIICoagulation
smpdb.ca/view/SMP0000586PhysiologicalThe TF-VIIa complex is the strongest known activator of the coagulation cascade, and converts factors IX and X to IXa and Xa, respectively. … Factors VII, IX, and X are vitamin-K-dependent proteins produced in the liver.
Enzymes: Coagulation factor IX, Coagulation factor VIIICoagulation
smpdb.ca/view/SMP0130473PhysiologicalIn the liver the coagulation factors VII, IX, and X are produced there as they are vitamin K-dependent proteins. … Fibrin at first is loose and unstable and is stabilized by coagulation factor XIIIa which cross-links them to form the fibrin clot/mesh that stops blood leaking from the vasculature system.
Enzymes: Coagulation factor IX, Coagulation factor VIIIPropyl alcohol Drug Metabolism
smpdb.ca/view/SMP0130505MetabolicPropyl alcohol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. … Propyl alcohol passes through the liver and is then excreted from the body mainly through the kidney.
Drugs: Propyl alcoholHuman Thrombin Action Pathway
smpdb.ca/view/SMP0126872Drug actionIt also acts on coagulation factor XIII to activate it and establish cross-linking of fibrin producing a clot. It is used as a topical application to a surgical site to minimize bleeding. … Human thrombin is a platelet-activating factor also known under the brand names Artiss, Evarrest, Evicel, Evithrom, Tachosil, Tisseel and Vistaseal.
Drugs: CalciumEnzymes: Coagulation factor IX, Coagulation factor VIIIGlutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseThe transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreEnzymes: Hypoxia-inducible factor 1-alpha inhibitorNicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP … The precursors are fed into the NAD+ biosynthetic pathwaythrough adenylation and phosphoribosylation reactions.
Fructose and Mannose Degradation
smpdb.ca/view/SMP0000064MetabolicFructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.