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Regulation of Lipolysis
smpdb.ca/view/SMP0573273Signalingfinally monoglyceride lipase (MGL), which liberates the last fatty acid and glycerol. … Adipocyte lipolysis is a highly regulated metabolic process in which triacylglycerols stored in lipid droplets are enzymatically hydrolyzed to free fatty acids and glycerol to meet systemic energy demands
Disulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. … This causes more dopamine to accumulate in the axon terminal and more dopamine is released.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreEthanol GABA Agonist Action Pathway
smpdb.ca/view/SMP0125151Drug actionThe main effects are seen by the binding to GABA receptors, glycine receptors, and glutamate receptors. … Hyperpolarization prevents depolarization and excitability of the neuron which causes a sedative effect in the brain.
Cocaine metabolism
smpdb.ca/view/SMP0125265MetabolicNorcocaine, benzoylecogonine, and cocaethylene all diffuse through the hepatic cell membrane into the blood where they travel to the kidney and are excreted renally. … However, cocaethylene is an active metabolite that is much more toxic than cocaine and has a higher affinity for dopamine re-uptake receptors, and therefore will activate similar pathways to cocaine.
Ethanol Degradation
smpdb.ca/view/SMP0000449MetabolicThe acetate leaves the mitochondria and moves to extra-hepatic tissues for further metabolism. … Ethanol degradation occurs via four pathways, three of which are oxidative pathways and are depicted here.
Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway
smpdb.ca/view/SMP0122693Drug actionThe compound also affects fatty acid transporters that are responsible for transferring reducing equivalents and oxidization as they are sensitive to acetaldehyde. … Acetaldehyde that accumulates in the mitochondrial matrix inhibits energy production seen by its inhibition of respiratory control and oxidative phosphorylation as some examples.
Ethanol Glycine Agonist Action Pathway
smpdb.ca/view/SMP0126452Drug actionThis causes an influx of chlorine ions which hyperpolarizes the neuron. Glycine receptors are present mainly in the spinal cord and brain stem where they control motor function. … The main effects are seen by the binding to GABA receptors, glycine receptors, and glutamate receptors. Ethanol agonizes glycine receptors, where glycine binds to the alpha subunit.
Ethanol NMDA Antagonist Action Pathway
smpdb.ca/view/SMP0126453Drug actionIn preventing their depolarization, ethanol prevents the creation and storage of memories. … This prevents the calcium channel from opening and allowing calcium into to the post-synaptic neuron.