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Displaying results 1 - 10 of 25 in total
  1. Target

    Sodium-dependent noradrenaline transporter

    go.drugbank.com/bio_entities/BE0000486
    TargetTransporterHumans

    Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). … Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed

    Synonyms: Norepinephrine transporter
  2. Target

    Alpha-2A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000289
    TargetHumans

    The rank order of potency for agonists of ADRA2A is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.

  3. Target

    Alpha-1A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000501
    TargetHumans

    ADRA1A binds the catecholamine ligands norepinephrine and epinephrine (PubMed:18802028, PubMed:37563160, PubMed:7815325, PubMed:8024574, PubMed:8183249, PubMed:8832064).

  4. Target

    Alpha-1D adrenergic receptor

    go.drugbank.com/bio_entities/BE0000715
    TargetHumans

    ADRA1D binds the catecholamine ligands norepinephrine and epinephrine (PubMed:7815325, PubMed:8024574, PubMed:8183249)

  5. Target

    Potassium channel subfamily K member 3

    go.drugbank.com/bio_entities/BE0003582
    TargetHumans

    In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation

  6. Target

    Solute carrier family 22 member 2

    go.drugbank.com/bio_entities/BE0003647
    TransporterCarrierHumans

    Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the

  7. Target

    Equilibrative nucleoside transporter 4

    go.drugbank.com/bio_entities/BE0004775
    TransporterTargetHumans

    Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation

  8. Target

    Alpha adrenergic receptor

    go.drugbank.com/bio_entities/BE0004888
    TargetHumans

    ADRA1D binds the catecholamine ligands norepinephrine and epinephrine (PubMed:7815325, PubMed:8024574, PubMed:8183249) … The rank order of potency for physiological agonists of ADRA2C is epinephrine > norepinephrine > dopamine (PubMed:2842764)

  9. Target

    Beta-1 adrenergic receptor

    go.drugbank.com/bio_entities/BE0000172
    TargetHumans

    Binds epinephrine and norepinephrine with approximately equal affinity (PubMed:33093660). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2 (PubMed:12391161).

  10. Target

    Alpha-2B adrenergic receptor

    go.drugbank.com/bio_entities/BE0000572
    TargetHumans

    The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.