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Displaying results 1 - 10 of 597 in total
  1. Pathway

    Sodium ascorbate Drug Metabolism

    smpdb.ca/view/SMP0130580
    Metabolic

    Sodium ascorbate passes through the liver and is then excreted from the body mainly through the kidney. … Sodium ascorbate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Sodium ascorbate
  2. Pathway

    Salicylate-Sodium Action Pathway

    smpdb.ca/view/SMP0000708
    Drug action

    Salicylate-sodium can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Salicylate-sodium (also named salsonin or clin) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used for relieving pain and reducing fever.

    Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Salicylic acid +5 more
  3. Pathway

    Salicylate-Sodium NSAID Action Pathway

    smpdb.ca/view/SMP0124630
    Drug action

    Salicylate-sodium is an NSAID which possesses anti-inflammatory, analgesic and antipyretic activity. … Salicylate-sodium inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).

    Drugs: Glutathione · Dinoprostone · Calcium · Salicylic acid · Mesoheme · Prostaglandin G2 +1 more
  4. Pathway

    Carbamazepine Sodium Channel Analgesic Action Pathway

    smpdb.ca/view/SMP0123059
    Drug action

    In neurons, voltage gated sodium channels allow sodium to come into the neuron triggering the depolarization phase. the potassium channels are responsible for the repolarization phase to bring the neuron … In neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, carbamazepine is able to produce a greater block in these neurons.

    Drugs: Carbamazepine · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily D member 2, Sodium channel subunit beta-2
  5. Pathway

    Tocainide Sodium Channel Antiepileptic Action Pathway

    smpdb.ca/view/SMP0126266
    Drug action

    In neurons, voltage gated sodium channels allow sodium to come into the neuron triggering the depolarization phase. the potassium channels are responsible for the repolarization phase to bring the neuron … Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias.

    Drugs: Tocainide · Potassium cation · Calcium
    Enzymes: Sodium channel protein type 5 subunit alpha, Potassium voltage-gated channel subfamily D member 2
  6. Pathway

    Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126519
    Drug action

    Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. … Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias.

    Drugs: Tocainide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  7. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding … , conduction rate, and force of contraction.

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel subunit beta-1
  8. Pathway

    Glutaminolysis and Cancer

    smpdb.ca/view/SMP0002298
    Disease

    The transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 more
    Enzymes: Sodium-coupled neutral amino acid transporter 5
  9. Pathway

    Metabolism and Physiological Effects of Oxalic acid

    smpdb.ca/view/SMP0124875
    Metabolic

    Glyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. … Glycine and hydroxyproline comes from protein sources in the diet such as red meat and eggs. Glycine Is converted into glyoxylate in the peroxisome by the enzyme d-amino acid oxidase.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 more
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Sodium- and chloride-dependent creatine transporter 1
  10. Pathway

    Metabolsim and Physiological Effects of Argininic acid

    smpdb.ca/view/SMP0125504
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Argininic acid is a uremic toxin that is toxic to the nervous system, and it causes various neurlogical disorders such as variable degree of mental retardation, epilepsy and progressive spasticity.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more