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Valacyclovir Action Pathway
smpdb.ca/view/SMP0125888Drug actionValacyclovir is rapidly and almost completely converted in man to aciclovir and valine, likely by the enzyme valacyclovir hydrolase. … Valaciclovir (valacyclovir), also known as the brand name Valtrex, is an guanine nucleoside antiviral used to treat herpes exacerbations. Valaciclovir is the L-valine ester of aciclovir.
Enzymes: Valacyclovir hydrolase, ABC transporter, substrate-binding lipoproteinGlucose Transporter Defect (SGLT2)
smpdb.ca/view/SMP0000184DiseaseSGLT2 is a sodium/glucose co-transporter that exists almost exclusively in kidney tissue.
Enzymes: Urea transporter 2, Y+L amino acid transporter 2Mitochondrial Electron Transport Chain
smpdb.ca/view/SMP0000355MetabolicFinally, the transfer of electrons from the reduced cytochrome c is catalyzed by cytochrome c oxidase, also known as complex IV of the electron transport chain. … Electrons donated by NADH can enter the electron transport chain as NADH dehydrogenase, known as complex I, facilitates their transfer to ubiquinone, also known as coenzyme Q10.
Drugs: Succinic acid · NADH · ATP · D-glyceraldehyde 3-phosphate · sn-glycerol 3-phosphate · Mesoheme +3 moreEnzymes: Cytochrome b-c1 complex subunit 8, Cytochrome b-c1 complex subunit 10Glucose Transporter Defect (SGLT2)
smpdb.ca/view/SMP0000245DiseaseThe major reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na()/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and has a Na()-to-glucose co...
Enzymes: Urea transporter 2, Y+L amino acid transporter 2Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway
smpdb.ca/view/SMP0126723Drug actionPhentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter.
Enzymes: Synaptic vesicular amine transporter, Sodium-dependent noradrenaline transporterMitochondrial Complex II Deficiency
smpdb.ca/view/SMP0125754DiseaseInterestingly, complex II deficiency gene mutation carriers may be at an increased risk for certain cancers. … Because complex II is found in the mitochondria, CII deficiency is technically considered a mitochondrial disease.
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialPyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125772DiseasePDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).
Enzymes: Monocarboxylate transporter 1, Monocarboxylate transporter 112-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000549Diseaseoxoglutarate dehydrogenase complex (OGDC). … 2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialPyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000212DiseasePDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialMitochondrial Complex II Deficiency
smpdb.ca/view/SMP0000548DiseaseInterestingly, complex II deficiency gene mutation carriers may be at an increased risk for certain cancers. … Because complex II is found in the mitochondria, CII deficiency is technically considered a mitochondrial disease.
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial