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Zolpidem Action Pathway (New)
smpdb.ca/view/SMP0125072Drug actionZolpidem is a sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. … Zolpidem binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS).
Zolpidem Predicted Metabolism Pathway
smpdb.ca/view/SMP0174792MetabolicMetabolites of Zolpidem are predicted with biotransformer.
Aldosterone from Steroidogenesis
smpdb.ca/view/SMP0121126PhysiologicalIt's function is to act on the distal convoluted tubule and the collecting duct of the nephron to make them more permeable to sodium to allow for its reuptake (in addition to allowing potassium wasting … Angiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade.
Indocyanine green acid form Drug Metabolism
smpdb.ca/view/SMP0130870MetabolicIndocyanine green acid form passes through the liver and is then excreted from the body mainly through the kidney. … Indocyanine green acid form is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indocyanine green acid formMultiple Carboxylase Deficiency, Neonatal or Early Onset Form
smpdb.ca/view/SMP0000564DiseaseThe BTD gene encodes for biotinidase and the HLCS gene encodes for holocarboxylase synthetase. … Holocarboxylase synthetase deficiency also called Multiple Carboxylase Deficiency, Neonatal or Early Onset Form, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of either mutations
2-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseD-2-Hydroxyglutaric Aciduria is an autosomal recessive disease caused by a mutation in the D2HGDH gene which does for D-2-Hydroxygluarate dehydrogenase. … L-2-Hydroxyglutaric Aciduria (D-2-Hydroxyglutaric Aciduria ) is an autosomal recessive disease caused by a mutation in the L2HGDH gene which codes for L-2-Hydroxygluarate dehydrogenase.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreAcylcarnitine (2Z)-2-(propan-2-yl)but-2-enedioylcarnitine
smpdb.ca/view/SMP0123554Metabolic-yl)but-2-enedioylcarnitine from forming and thereby preventing it from being transported into the mitochondria. … The general role of acylcarnitines is to transport acyl-groups, organic acids and fatty acids, from the cytoplasm into the mitochondria so that they can be broken down to produce energy.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreMultiple Carboxylase Deficiency, Neonatal or Early Onset Form
smpdb.ca/view/SMP0125778DiseaseThe BTD gene encodes for biotinidase and the HLCS gene encodes for holocarboxylase synthetase. … Holocarboxylase synthetase deficiency also called Multiple Carboxylase Deficiency, Neonatal or Early Onset Form, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of either mutations
Fc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingFc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.
Enzymes: Linker for activation of T-cells family member 1mTOR Signaling pathway
smpdb.ca/view/SMP0535455SignalingCellular energy status is sensed by AMPK, which upon activation by a high AMP/ATP ratio phosphorylates TSC2 and the mTORC1 subunit Raptor to inhibit mTORC1, whereas high ATP from glycolysis suppresses … Amino acids signal through distinct routes: Leucine binds to CASTOR1 to dissociate it from GATOR2, blocking GATOR1 and enabling RagA/B‑GTP loading to recruit mTORC1 to lysosomes; Arginine is sensed by
Enzymes: Cytosolic arginine sensor for mTORC1 subunit 1