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  1. Pathway

    Zolpidem Action Pathway (New)

    smpdb.ca/view/SMP0125072
    Drug action

    Zolpidem is a sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. … Zolpidem binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS).

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Zolpidem · Calcium · Magnesium cation +3 more
  2. Pathway

    Zolpidem Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174792
    Metabolic

    Metabolites of Zolpidem are predicted with biotransformer.

    Drugs: Zolpidem · Mesoheme
  3. Pathway

    Aldosterone from Steroidogenesis

    smpdb.ca/view/SMP0121126
    Physiological

    It's function is to act on the distal convoluted tubule and the collecting duct of the nephron to make them more permeable to sodium to allow for its reuptake (in addition to allowing potassium wasting … Angiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade.

    Drugs: NADH · Progesterone · Mesoheme · Cholesterol · Corticosterone
  4. Pathway

    Fc Epsilon Receptor I Signaling in Mast Cells

    smpdb.ca/view/SMP0000358
    Signaling

    Fc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.

    Drugs: Heparin · Calcium · Magnesium cation · Zinc · Prostaglandin D2 · Arachidonic Acid
    Enzymes: Linker for activation of T-cells family member 1
  5. Pathway

    mTOR Signaling pathway

    smpdb.ca/view/SMP0535455
    Signaling

    Cellular energy status is sensed by AMPK, which upon activation by a high AMP/ATP ratio phosphorylates TSC2 and the mTORC1 subunit Raptor to inhibit mTORC1, whereas high ATP from glycolysis suppresses … Amino acids signal through distinct routes: Leucine binds to CASTOR1 to dissociate it from GATOR2, blocking GATOR1 and enabling RagA/B‑GTP loading to recruit mTORC1 to lysosomes; Arginine is sensed by

    Drugs: Arginine · L-Glutamine · Leucine · ATP · Magnesium cation · Zinc
    Enzymes: Cytosolic arginine sensor for mTORC1 subunit 1