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Malate-Aspartate Shuttle
smpdb.ca/view/SMP0000129MetabolicWhen the malate gets inside the membrane,the energy inside of malate is taken out by creating NADH from NAD+, which regenerates oxaloacetate. … The malate-aspartate shuttle is needed as the inner membrane is not permeable to NADH or NAD+, but is permeable to the ions that attach to malate.
Enzymes: Malate dehydrogenase, mitochondrial, Mitochondrial 2-oxoglutarate/malate carrier proteinProchlorperazine - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126629Drug actionProchlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. … Dopamine-antagonizing medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 moreMagnesium malate Drug Metabolism
smpdb.ca/view/SMP0130544MetabolicMagnesium malate passes through the liver and is then excreted from the body mainly through the kidney. … Magnesium malate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Magnesium malateProchlorperazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126604Drug actionProchlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. … Dopamine-antagonizing medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 moreDexchlorpheniramine maleate Drug Metabolism
smpdb.ca/view/SMP0130637MetabolicDexchlorpheniramine maleate passes through the liver and is then excreted from the body mainly through the kidney. … Dexchlorpheniramine maleate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Dexchlorpheniramine maleateDexchlorpheniramine maleate H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175046Drug actionDexchlorpheniramine maleate inhibits the H1 histamine receptor on blood vessel endothelial cells. … Dexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.
Dexchlorpheniramine maleate H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175138Drug actionDexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.
Dexchlorpheniramine maleate H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174954Drug actionDexchlorpheniramine maleate also inhibits the H1 histamine receptor on bronchiole smooth muscle myocytes. … Dexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.
Transfer of Acetyl Groups into Mitochondria
smpdb.ca/view/SMP0000466MetabolicMalate can also be used to create NADH by the conversion of malate to oxalacetic acid by malate dehydrogenase. … Malate dehydrogenase reduces oxalacetic acid to malate, which then is either transported back into the mitochondria by the malate-alpha ketoglutarate transporter or oxidized to pyruvate by malic enzyme
Enzymes: Malate dehydrogenase, cytoplasmic, Mitochondrial 2-oxoglutarate/malate carrier proteinGlycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
smpdb.ca/view/SMP0000374DiseaseGlycogen storage disease type 1A (GSD1A), or von Gierke disease, is caused by a defect in the G6PC gene which codes for Glucose-6-phosphatase. Glucose-6-phosphatase hydrolyzes glucose-6-phosphate to glucose and is responsible for the reg...
Enzymes: Malate dehydrogenase, mitochondrial, Mitochondrial 2-oxoglutarate/malate carrier protein