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Displaying drugs 3126 - 3150 of 11512 in total

Anethole trithione

Anethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia [A27165, A32618, A32620, A32621], to demonstrating an ability to inhibit carcinogenesis by increasing the activity of electrophile detoxification enzymes , and even being used as an adjunctive therapy for cholecystitis,...
Approved
Experimental
Matched Description: … Anethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary …

Cholecystokinin

Cholecystokinin ( also known as CCK or CCK-PZ) is a peptide hormone of the gastrointestinal system which is responsible for stimulating the digestion of fat and protein. Cholecystokinin, previously called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum (the first portion of the small intestine) and leads...
Approved
Investigational
Matched Description: … Cholecystokinin ( also known as _CCK or CCK-PZ_) is a peptide hormone of the gastrointestinal system ... Recent studies have suggested that cholecystokinin also plays a major role in inducing drug tolerance …

Ambrosia ambrosioides pollen

Ambrosia ambrosioides pollen is the pollen of the Ambrosia ambrosioides plant. Ambrosia ambrosioides pollen is mainly used in allergenic testing.
Approved

Ferrous glycine sulfate

Approved

Vedolizumab

Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative colitis or Crohn's disease. α4β7 integrin facilitates the interaction between lymphocytes and gut endothelial cells through the α4β7 integrin-MAdCAM1 interaction, leading to the mobilization...
Approved
Matched Description: … Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte ... α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative ... [A261576] Vedolizumab is administered by IV infusion over a period of 30 minutes; after the first dose …

Galactose

Galactose has been used in trials studying the treatment and diagnosis of Hepatitis C, Hepatic Cancer, Wilsons Disease, Diabetic Macular Oedema, and Focal Segmental Glomerulosclerosis, among others. There are even proposals for its use in accelerating senescence in mice, rats, and Drosophila, for its association with ovarian cancer, or even...
Approved
Investigational
Matched Description: … As a naturally occurring sugar, it may be found in a number dairy products. ... Even then, however, it is not generally used as a sweetener considering it is only about 30% as sweet ... Regardless, although it is predominantly used as a pathway to generate glucose fuel for the human body …

Bismuth subsalicylate

Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of salicylic acid linked to trivalent bismuth cation. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth subsalicylate has been around for over 100 years: it...
Approved
Vet approved
Matched Description: … [A230728] It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that ... ], and [tetracycline]), which is a treatment regimen indicated for the eradication of _H. pylori_ for ... [L32318] Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, [metronidazole …

Lusutrombopag

Lusutrombopag is an orally bioavailable thrombopoietin receptor (TPOR) agonist developed by Shionogi & Company (Osaka, Japan). TPOR is a regulatory target site for endogenous thrombopoietin, which acts as a primary cytokine to promote megakaryocyte proliferation and differentiation, and affect other hematopoietic lineages as well, including erythroid, granulocytic and lymphoid lineages...
Approved
Investigational
Matched Description: … TPOR is a regulatory target site for endogenous thrombopoietin, which acts as a primary cytokine to promote ... Thrombocytopenia, which indicates abnormally low levels of platelets, is a common complication related ... count <50,000/μL), creates challenges to patients requiring invasive medical procedures where there is a …

Yohimbine

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Approved
Investigational
Vet approved
Matched Description: … A plant alkaloid with alpha-2-adrenergic blocking activity. ... Yohimbine has been used as a mydriatic and in the treatment of impotence. …

Pexidartinib

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial...
Approved
Investigational
Matched Description: … risk of significant functional limitations and a reduced quality of life in patients. ... Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating ... [L7901] Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Ditiocarb zinc

Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen. Sensitivity to ditiocarb zinc may be identified with a clinical patch test.
Approved
Matched Description: … It also a dermatological sensitizer and allergen. ... Sensitivity to ditiocarb zinc may be identified with a clinical patch test. ... Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Sulpiride

Sulpiride first appeared in published literature in 1967. Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses. Sulpiride is not approved by the FDA, Health Canada, or the EMA; though...
Approved
Investigational
Matched Description: … [A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather …

Antipyrine

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Approved
Investigational

Anacaulase

Anacaulase (anacaulase-bcdb) is a mixture of proteolytic enzymes extracted from the stems of pineapple plants (Ananas comosus [L.] Merr.). It is mostly composed (80-95% w/w) of proteins such as stem bromelain, ananain, jacalin-like lectin, bromelain inhibitors, and phytocystatin inhibitor, as well as saccharides, as both free monosaccharides and the N-linked...
Approved
Investigational
Matched Description: … trauma, major blood and heat loss and adjacent tissue damage. ... Anacaulase (anacaulase-bcdb) is a mixture of proteolytic enzymes extracted from the stems of pineapple ... Removing eschar (a process also known as debridement) through surgical procedures can lead to significant …

Diltiazem

Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle...
Approved
Investigational
Matched Description: … Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. ... Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug ... [T28] Being a potent vasodilator, diltiazem is used clinically as an antihypertensive, anti-arrhythmic …

Rhizopus arrhizus var. arrhizus

Rhizopus arrhizus var. arrhizus is a fungus which can provoke allergic reactions. Rhizopus arrhizus var. arrhizus extract is used in allergenic testing.
Approved
Matched Description: … Rhizopus arrhizus var. arrhizus is a fungus which can provoke allergic reactions. …

Verteporfin

Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: CL-315555 and CL-315585. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red...
Approved
Investigational
Matched Description: … Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers ... It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form ... Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a …

Methscopolamine bromide

A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Approved
Matched Description: … A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors. …

Butabarbital

Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. Its short duration of action...
Approved
Illicit
Matched Description: … Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other ... [A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative ... [A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital …

Cabergoline

Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Approved
Matched Description: … Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Trihexyphenidyl

Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant...
Approved
Matched Description: … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced ... [L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity ... [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment …

Anifrolumab

Anifrolumab, or MEDI-546, is a type 1 interferon receptor (IFNAR) inhibiting IgG1κ monoclonal antibody indicated in the treatment of adults with moderate to severe systemic lupus erythematosus.[A237074,L34929] The standard therapy for systemic lupus erythematosus consists of antimalarials like hydroxychloroquine, glucocorticoids like dexamethasone, and disease modifying antirheumatic drugs like methotrexate.[A237079,L34929] Three...
Approved
Investigational
Matched Description: … Anifrolumab, or MEDI-546, is a type 1 interferon receptor (IFNAR) inhibiting IgG1κ monoclonal antibody …

Orlistat

The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical intervention is required. Orlistat is a...
Approved
Investigational
Matched Description: … It was approved by the FDA for use in combination with a reduced-calorie diet in 1999. ... [A229928] Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting ... [L11130] This drug is a generally well-tolerated and effective weight-loss aid and is now available in …

Golimumab

Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … The FDA label includes a black box warning of serious infections and malignancy. ... Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with ... as an adjunct to methotrexate treatment in patients with active psoriatic arthritis (PsA), (iii) as a …

Odevixibat

Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC).[A236808,L34793] Odevixibat is the first approved non-surgical treatment option for PFIC. Previous therapies for PFIC included a bile acid sequestrant such as ursodeoxycholic...
Approved
Investigational
Matched Description: … [L34803] Previous therapies for PFIC included a bile acid sequestrant such as [ursodeoxycholic acid]. …
Displaying drugs 3126 - 3150 of 11512 in total