Displaying drugs 3551 - 3575 of 12485 in total
Phenindamine
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor...
Approved
Matched Description: … Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears …
Teplizumab
Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay …
Tezepelumab
Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes. Blocking the...
Approved
Investigational
Matched Description: … Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low ... A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a ... [A243764, A243769, A243774]
Tezepelumab is a human monoclonal IgG2λ antibody directed against TSLP …
Juniperus californica pollen
Juniperus californica pollen is the pollen of the Juniperus californica plant. Juniperus californica pollen is mainly used in allergenic testing.
Approved
Artemisia douglasiana pollen
Artemisia douglasiana pollen is the pollen of the Artemisia douglasiana plant. Artemisia douglasiana pollen is mainly used in allergenic testing.
Approved
Elafibranor
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist that works to inhibit bile acid synthesis. On June 10, 2024, elafibranor was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis (PBC).
Approved
Investigational
Matched Description: … Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist [A263833] that …
Strontium chloride Sr-89
Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stages of the disease. It...
Approved
Investigational
Matched Description: … Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option ... [A31264] Bone metastases is a common and severe complication presented in advanced stages of the disease ... There has been some cases of apparent tumor regression which has given it a potential tumoricidal effect …
Choline C 11
Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes. It was developed by MCPRF and FDA first approved in September 2012.
Approved
Investigational
Matched Description: … Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis …
Apricot kernel oil
Apricot kernel oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Apricot kernel oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Pirfenidone
Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is proposed to primarily regulate...
Approved
Investigational
Matched Description: … Pirfenidone is a synthetic pyridone drug. ... antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a …
Diosmin
Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from hesperidin. It is used for the improvement of capillary fragility or...
Approved
Investigational
Matched Description: … Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile ... Chronic venous insufficiency is a common condition the western population. ... [A232885]
Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. …
Nirogacestat
Nirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. Desmoid tumors are typically characterized by aberrant activation in Notch signaling. Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling...
Approved
Investigational
Matched Description: … Nirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment ... tumors, and the final approval was based on positive results obtained in the Phase 3 DeFi trial, where a …
Voxilaprevir
Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 ... Voxilaprevir has been available since July 2017 in a fixed dose combination product with [sofosbuvir] …
Arnica montana flower
Arnica montana flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Arnica montana flower is a plant/plant extract used in some OTC (over-the-counter) products. …
Epcoritamab
Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells.[A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads to the T-cell–mediated killing of CD20+ malignant B cells.[A259761,L46516] Diffuse large B-cell lymphoma...
Approved
Investigational
Matched Description: … for the treatment of a variety of hematologic malignancies. ... approval for this indication may be contingent upon verification and description of clinical benefit in a ... [L46516] It is administered subcutaneously and is currently being evaluated as a monotherapy and in combination …
Mebeverine
Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
Approved
Investigational
Betrixaban
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals...
Approved
Investigational
Matched Description: … Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible ... Betrixaban, now developed by Portola Pharmaceuticals Inc., is prescribed as a venous thromboembolism ... VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable …
Morpholinylmercaptobenzothiazole
Approved
Experimental
Efgartigimod alfa
Myasthenia gravis (MG) is an autoimmune disorder characterized by significant muscle weakness - particularly in the eye, throat, and extremities - caused by autoantibodies attacking the neuromuscular junction. The production of IgG autoantibodies against acetylcholine receptors (AChRs) is one of the more common pathophysiological mechanisms behind MG, and results in...
Approved
Investigational
Matched Description: … common pathophysiological mechanisms behind MG, and results in the destruction of these receptors and a ... L39496] IgG antibodies, including the autoantibodies responsible for MG symptoms, can be 'recycled', a ... [A243759,A243784]
Efgartigimod alfa is a first-in-class[L39501] antagonist of the neonatal Fc receptor …
Somatrem
Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disposition of short...
Approved
Investigational
Withdrawn
Matched Description: … discussion revolves around whether patients' natural disposition of short stature should be considered a …
Desloratadine
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Approved
Investigational
Matched Description: … Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral ... It is the active descarboethoxy metabolite of loratidine (a second generation histamine). ... Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter …
Methoxsalen
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Approved
Matched Description: … It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. ... A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Vestronidase alfa
Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. The enzyme is a homotetramer consisted of 4 monomers with 629 amino acids, and holds the same amino acid sequence as...
Approved
Investigational
Matched Description: … is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. ... MPS VII is a progressive condition that affects most tissues and organs due to the lack of a lysosomal ... Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that …
Magnesium acetate
Approved
Megestrol acetate
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Description: … A progestational hormone used most commonly as the acetate ester. ... As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor …
Displaying drugs 3551 - 3575 of 12485 in total