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Displaying drugs 376 - 400 of 13680 in total

Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA) is a progesterone derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is also...
Approved
Investigational
Matched Iupac: … )-1-acetyl-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … , and is also used in palliative care for endometrial and renal carcinoma. ... for improved pharmacokinetic properties. ... Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Mefenamic acid

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Approved
Matched Description: … A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties …

Olanzapine

Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Description: … due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility ... [T554] It was discovered by scientists at Eli Lilly and approved to be marketed in the US in 1996. ... Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent …
Matched Products: … Olanzapine for Injection …

Esculin

Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculin belongs to the family of Glycosyl...
Approved
Matched Description: … These are carbohydrate derivatives in which a sugar group is bonded through its anmoeric carbonA to another ... Esculin is found in barley. ... Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally …

Cetuximab

Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … [A227963] Approved by the FDA in February 2004 under the brand name ERBITUX, cetuximab is used for ... [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. ... [A227973] EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour …
Matched Products: … ERBITUX 5MG/ML SOLUTION FOR INFUSION …

Human vaccinia virus immune globulin

Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody [FDA Label, A33814]. The IgG fraction is purified by the anion-exchange column chromatography...
Approved
Matched Description: … product that is only available in very limited quantities - all factors that may intervene with its ... Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG ... , which contain no preservatives - unlike prior intramuscular compounds which contained thiomersal, a …

Methyl aminolevulinate

Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.
Approved
Investigational
Matched Description: … in photodynamic therapy. ... Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used …
Matched Categories: … Photosensitizing Agents for Phototherapy ... Sensitizers Used in Photodynamic/radiation Therapy …

Oxygen

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow...
Approved
Vet approved
Matched Description: … Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing ... It is an essential element for human survival. ... blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt …
Matched Mixtures name: … Oxygen In Helium Mix ... Nitrous Oxide In Oxygen ... Oxygen In Helium Mixture …
Matched Products: … N/A …

Thyrotropin alfa

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Description: … Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests ... It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients ... The alpha subunit of thyrotropin alfa, which is the effector region responsible for the stimulation of …
Matched Products: … Thyrogen 0.9 mg Powder for Solution for Injection …

Methylphenidate

Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally...
Approved
Investigational
Matched Description: … The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing ... products and amphetamines, have a high potential for abuse and dependence. ... Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing. …
Matched Categories: … Medications that reduce magnesium levels ... Psychostimulants, Agents Used for ADHD and Nootropics …

Eculizumab

Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246] Eculizumab was granted FDA approval on 16 March 2007. In Q1 2023, the EMA's Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive ... is used to treat a number of autoimmune conditions. ... Eculizumab is a monoclonal antibody that targets complement protein C5. …
Matched Products: … Soliris Concentrate for Solution for Infusion 300mg/vial …

Imipramine

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … In depressed individuals, imipramine exerts a positive effect on mood. ... receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for ... Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. …
Matched Categories: … Antidepressive Agents Indicated for Depression ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C18 Substrates with a Narrow Therapeutic Index …

Ibrutinib

Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in...
Approved
Matched Description: … It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies ... 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. ... for the treatment of mantle cell lymphoma (MCL) under accelerated approval;[L12228] however, in April …

Bexagliflozin

Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.[A256408,A256413,L44758] Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such as SGLT1, SGLT2 is...
Approved
Investigational
Matched Description: … [A256423,L44758] In January 2023, bexagliflozin was approved by the FDA for the treatment of adults with ... reabsorption of filtered glucose and increases urinary glucose excretion, which reduces blood glucose levels ... as SGLT1, SGLT2 is mainly expressed in the kidney. …
Matched Categories: … Drugs Used in Diabetes …

Raloxifene

Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific effects distinct from estradiol, raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM....
Approved
Investigational
Matched Description: … Due to the decline in estrogen levels in postmenopausal osteoporosis, hormone replacement therapy (HRT ... women and reduction in risk for invasive breast cancer in postmenopausal women with osteoporosis or ... In addition, a clinical study consisting of postmenopausal women with documented coronary heart disease …
Matched Categories: … Medications that reduce magnesium levels …

Dalfampridine

Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Approved
Matched Description: … Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. ... This is the first drug that was specifically approved to help with mobility in these patients. …
Matched Categories: … OCT2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index …

Human thrombin

Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This transformation mimics the final coagulation cascade step which involves the clotting mass...
Approved
Matched Description: … Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation ... In particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin ... is a human coagulation protein produced via recombinant DNA technology from a genetically modified Chinese …
Matched Mixtures name: … ARTISS SOLUTIONS FOR SEALANT, DEEP FROZEN …

Dacomitinib

Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Description: … [L4810] Some evidence in the literature suggests the therapeutic potential of dacomitinib in the epithelial …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Macimorelin

Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels...
Approved
Investigational
Matched Description: … They include treatment for growth retardation in children and cachexia associated with chronic disease ... In clinical studies involving healthy subjects, macimorelin stimulated GH release in a dose-dependent ... name Macrilen for oral solution. …
Matched Categories: … Tests for Pituitary Function …

Argatroban

Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
Matched Description: … Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT ... have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary ... Argatroban is a direct, selective thrombin inhibitor. …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Belladonna

Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family Solanaceae. Its roots, leaves and fruits contain DB00424, DB00747, and mostly, DB00572. These alkaloids are naturally-occurring muscarinic antagonists. DB00572 is a non-selective muscarinic antagonist that is mainly used as an adjunct for...
Approved
Experimental
Matched Description: … Belladonna is a poisonous plant and belladonna intoxication from accidental ingestion may result in a ... Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in ... [DB00572] is a non-selective muscarinic antagonist that is mainly used as an adjunct for anaesthesia. …

Avalglucosidase alfa

Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Description: … [A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. ... Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe ... GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. …

Treprostinil

Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment...
Approved
Investigational
Matched Description: … [L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin ... Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. ... Treprostinil is a stable tricyclic analogue of prostacyclin[A248770] that promotes the vasodilation of …

Fibrinogen human

Fibrinogen concentrate (human) is a hematological agent. It works by replacing a certain protein in the blood that helps with blood clotting. Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. It is a physiological substrate for three enzymes: plasmin, factor XIIIa and...
Approved
Matched Description: … It is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency ... It works by replacing a certain protein in the blood that helps with blood clotting. ... It is a physiological substrate for three enzymes: plasmin, factor XIIIa and thrombin. …
Matched Mixtures name: … Artiss Solutions for Sealant, Deep Frozen ... ARTISS SOLUTIONS FOR SEALANT, DEEP FROZEN …
Matched Products: … HAEMOCOMPLETTAN P POWDER FOR SOLUTION FOR INJECTION OR INFUSION 1G/VIAL ... Fibryga 1g Powder and Solvent for Solution for Injection or Infusion ... FIBRYGA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION OR INFUSION 1G/VIAL …

Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from …
Displaying drugs 376 - 400 of 13680 in total