Displaying drugs 651 - 675 of 11619 in total
Benzhydrocodone
Benzhydrocodone is a benzylic prodrug of hydrocodone. It was developed in an effort to reduce parenteral bioavailability of the active metabolite as a deterrent to abuse. Benzhydrocodone is indicated for use in the short-term management of pain. It was first approved by the FDA in February 2018 in combination with...
Approved
Matched Description: … Benzhydrocodone is a benzylic prodrug of hydrocodone. ... L4894] It was developed in an effort to reduce parenteral bioavailability of the active metabolite as a …
Flumethasone
Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Approved
Vet approved
Matched Description: … Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic ... As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. ... This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching …
Capreomycin
Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.
Approved
Matched Categories: … Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …
Mipomersen
Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in...
Approved
Investigational
Matched Description: … Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic ... It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black ... Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Inclisiran
Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein cholesterol (LDL-C) levels. By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma...
Approved
Investigational
Matched Description: … Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase ... subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein ... risk of cardiovascular disease (CVD) and improving cardiovascular outcomes, as hypercholesterolemia is a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Mercaptopurine
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Approved
Matched Categories: … OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index …
Bismuth subsalicylate
Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of salicylic acid linked to trivalent bismuth cation. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth subsalicylate has been around for over 100 years: it...
Approved
Vet approved
Matched Description: … [A230728] It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that ... ], and [tetracycline]), which is a treatment regimen indicated for the eradication of _H. pylori_ for ... [L32318] Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, [metronidazole …
Golimumab
Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … The FDA label includes a black box warning of serious infections and malignancy. ... Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with ... as an adjunct to methotrexate treatment in patients with active psoriatic arthritis (PsA), (iii) as a …
Spesolimab
Spesolimab is an interleukin-36 (IL-36) receptor antagonist. It is a humanized monoclonal immunoglobulin G1 antibody that was produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. The biosimilar of the drug, spesolimab-sbzo, was first approved by the FDA in September 2022 to treat generalized pustular psoriasis flares. Spesolimab...
Approved
Investigational
Matched Description: … It is a humanized monoclonal immunoglobulin G1 antibody that was produced in Chinese hamster ovary (CHO …
Insulin pork
Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
Approved
Matched Description: … Forms a hexameric structure. …
Butabarbital
Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. Its short duration of action...
Approved
Illicit
Matched Description: … Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other ... [A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative ... [A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital …
Pirbuterol
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is...
Approved
Matched Description: … Pirbuterol is a beta-2 adrenergic bronchodilator. ... population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. ... In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Ondansetron
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has...
Approved
Withdrawn
Matched Description: … A competitive serotonin type 3 receptor antagonist. ... single dose, due to a high risk of QT prolongation. ... 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a …
Anistreplase
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived...
Approved
Matched Description: … A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human ... Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the ... primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase …
Succinic acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of...
Approved
Nutraceutical
Matched Description: … It is also used in foods as a sequestrant, buffer, and a neutralizing agent. ... A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine …
Thrombin alfa
Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa precursor is secreted to culture medium as single chain form that is proteolytically...
Approved
Matched Description: … Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically ... two-chain active form (using a protein derived from snakes) and is purified by a chromatographic process ... that yields a product having hemostatic activities similar to native human thrombin. …
Mandelic acid
Mandelic acid is an approved aromatic, alpha hydroxy acid . Mandelic acid is used as an ingredient in cosmetics and drug products applied topically.
Approved
Aprocitentan
Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension. It is the active metabolite of macitentan.
Approximately 10-15% of patients with hypertension have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a renin-angiotensin system blocker, a calcium channel blocker,...
Approved
Investigational
Matched Description: … Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension ... renin-angiotensin system blocker, a calcium channel blocker, and a diuretic at maximally tolerated doses ... have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a …
Dihydroergocornine
Dihydroergocornine is one of the dihydrogenated ergot compounds that present very large hypotensive effects. It is an artificial derivative of the crude extract of ergot and later purified, ergocornine. The formation of dihydroergocornine implies the hydrogenation of the double bonds in the lysergic acid. Dihydroergocornine presents a formula of 9,10...
Approved
Matched Description: … [A32965] Dihydroergocornine presents a formula of 9,10 alpha-dihydro-12'-hydroxy-2',5'alpha-bis(1-methylethyl …
Belantamab mafodotin
Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufacturer began the process for withdrawal of the...
Approved
Matched Description: … available for patients in the Risk Evaluation and Mitigation Strategy (REMS) program who can enrol in a …
Rilpivirine
Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potency and reduces the chance of resistance...
Approved
Matched Description: … [A31328] It is a diarylpyrimidine derivative. ... conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a …
Xanthinol
Xanthinol is a very potent water-soluble derivative of niacin that can be found in diet supplements. It is also known as xanthinol nicotinate. Xaninthol is known to be a potent vasodilator that can easily pass through the cell membrane and once inside the cell it causes an increase in glucose...
Approved
Withdrawn
Matched Description: … Xanthinol is a very potent water-soluble derivative of niacin that can be found in diet supplements. ... [L1079] Xaninthol is known to be a potent vasodilator that can easily pass through the cell membrane ... [L1080] It was approved as a drug in 1998 in Canada and nowadays its status is cancelled post marketing …
Valine
Valine is a branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.
Approved
Nutraceutical
Matched Description: … It is a precursor in the penicillin biosynthetic pathway. ... Valine is a branched-chain essential amino acid that has stimulant activity. …
Voclosporin
Lupus nephritis (LN) is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus (SLE). LN is a significant cause of renal failure, morbidity, and death in patients with SLE. Within 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a...
Approved
Investigational
Matched Description: … LN is a significant cause of renal failure, morbidity, and death in patients with SLE. ... Lupus nephritis (LN) is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus ... years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a …
Propanoic acid
Sodium propionate is the sodium salt of propionic acid that exists as colorless, transparent crystals or a granular crystalline powder. It is considered generally recognized as safe (GRAS) food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and flavoring agent. Its use as a food...
Approved
Vet approved
Matched Description: … Its use as a food additive is also approved in Europe. ... Sodium propionate is the sodium salt of propionic acid that exists as colorless, transparent crystals or a …
Displaying drugs 651 - 675 of 11619 in total