Displaying drugs 776 - 800 of 11612 in total
Topiramate
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. ... chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. ... [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel …
Nabilone
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … for such a wide variety of medical conditions. ... Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. ... (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. …
Upadacitinib
Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Description: … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic ... Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. ... [A189165] Despite a variety of therapeutic agents available for treatment, up to 40% of the patients …
Glimepiride
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Description: … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class ... Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Compared to [glipizide], another second SU drug, glimepiride has a longer duration of action. …
Azadirachta indica leaf
Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Labetalol
Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730]
Labetalol was granted FDA approval on 1 August 1984.
Approved
Matched Description: … Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up …
Chlorzoxazone
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Approved
Matched Description: … A centrally acting central muscle relaxant with sedative properties. …
Palovarotene
Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … It first garnered interest as a potential treatment for emphysema but was eventually recognized as a ... ], which are derivatives of [vitamin A]. ... [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive …
Sodium stibogluconate
Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium stibogluconate is sold in the UK as Pentostam (manufactured by GlaxoSmithKline). Widespread resistance has limited the utility of sodium stibogluconate,...
Approved
Investigational
Matched Description: … Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration …
Panthenol
Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol). While pantothenic acid is optically active, only the dextrorotatory...
Approved
Matched Description: … essential component of a normally functioning epithelium. ... Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an ... Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the …
Diamorphine
Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Description: … It is a controlled substance (opium derivative) listed in the U.S. ... Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. ... However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom. …
Pitolisant
Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnagogic hallucinations. About...
Approved
Investigational
Matched Description: … In a European clinical trial of adult patients with narcolepsy, there was a reduction in the Epworth ... Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type ... [A32025] About 60-70% of patients with narcolepsy experience cataplexy, which is a sudden loss of muscle …
Tetradecyl hydrogen sulfate (ester)
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins .
Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Description: … 30% incidence of post-sclerosis pigmentation that resolved within a few months [L2035]. ... sulfate has been widely used since the 1950s, and in 1978 the first successful report of injecting a ... surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a …
Tildrakizumab
Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis .
The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy...
Approved
Investigational
Matched Description: … A study was performed on the pharmacokinetics of this drug on various ethnicities. ... Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows ... The approved recommended dosage of ILUMYA is a subcutaneous injection of 100 mg at Weeks 0, 4, and every …
Ropivacaine
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Approved
Matched Description: … It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the …
Perindopril
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor ... Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Rumex acetosella pollen
Rumex acetosella pollen is the pollen of the Rumex acetosella plant. Rumex acetosella pollen is mainly used in allergenic testing.
Approved
Phycomyces blakesleeanus
Phycomyces blakesleeanus is a fungus which can provoke allergic reactions. Phycomyces blakesleeanus extract is used in allergenic testing.
Approved
Matched Description: … Phycomyces blakesleeanus is a fungus which can provoke allergic reactions. …
Rumex altissimus pollen
Rumex altissimus pollen is the pollen of the Rumex altissimus plant. Rumex altissimus pollen is mainly used in allergenic testing.
Approved
Fanolesomab
Approved
Experimental
Corydalis ambigua tuber
Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. …
Haloperidol
Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within...
Approved
Matched Description: … Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently ... [A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain ... of chorea associated with Huntington's disease and for the treatment of intractable hiccups as it is a …
Ezogabine
Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy....
Approved
Investigational
Matched Description: … It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED ... Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. …
Cefradine
A semi-synthetic cephalosporin antibiotic.
Approved
Matched Description: … A semi-synthetic cephalosporin antibiotic. …
Amaranthus retroflexus whole
Amaranthus retroflexus whole allergenic extract is used in allergenic testing.
Approved
Displaying drugs 776 - 800 of 11612 in total