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Displaying drugs 576 - 600 of 878 in total

Clomipramine

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals,...
Approved
Investigational
Vet approved
Matched Description: … TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... , are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and ... receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred …
Matched Salts name: … Clomipramine hydrochloride …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Matched Products: … Clomipramine Hydrochloride ... clomiPRAMINE Hydrochloride ... Clomipramine hydrochloride …

Valganciclovir

Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Approved
Investigational
Matched Description: … After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases ... Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat …
Matched Salts name: … Valganciclovir hydrochloride …
Matched Categories: … Ganciclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Products: … Valganciclovir Hydrochloride ... Valganciclovir hydrochloride ... Valganciclovir hydrochloride for Oral …

CTX120

CTX120 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting B-cell maturation antigen.
Investigational
Matched Synonyms: … allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting B-cell maturation antigen …
Matched Description: … CTX120 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting B-cell …

Chlorpromazine

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Approved
Investigational
Vet approved
Matched Description: … Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the …
Matched Salts name: … Chlorpromazine hydrochloride …
Matched Products: … Chlorpromazine Hydrochloride ... Chlorpromazine hydrochloride ... ChlorproMAZINE Hydrochloride …

Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain . Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Approved
Matched Description: … (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. ... Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine ... Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. …
Matched Salts name: … Vilazodone hydrochloride …
Matched Categories: … Serotonin antagonist and reuptake inhibitors (SARIs) …
Matched Products: … Vilazodone Hydrochloride ... Vilazodone hydrochloride …

Phenoxybenzamine

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Approved
Matched Description: … It has been used to treat hypertension and as a peripheral vasodilator. …
Matched Salts name: … Phenoxybenzamine hydrochloride …
Matched Products: … Phenoxybenzamine Hydrochloride ... Phenoxybenzamine hydrochloride …

Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Description: … Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. ... , such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. ... receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and …
Matched Salts name: … Buspirone hydrochloride …
Matched Categories: … Miscellaneous Anxiolytics Sedatives and Hypnotics …
Matched Products: … Buspirone Hydrochloride ... BusPIRone Hydrochloride ... Buspirone hydrochloride …

Isoxsuprine

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
Approved
Withdrawn
Matched Description: … A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. ... It is used in the treatment of peripheral vascular disease and in premature labor. …
Matched Salts name: … Isoxsuprine hydrochloride …
Matched Products: … Isoxsuprine Hydrochloride ... ISOXSUPRINE HYDROCHLORIDE …

Cysteine

A thiol-containing non-essential amino acid that is oxidized to form cystine.
Approved
Nutraceutical
Matched Salts name: … Cysteine hydrochloride …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Cysteine Hydrochloride ... L-Cysteine Hydrochloride …

Epinastine

Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to...
Approved
Investigational
Matched Description: … H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory ... cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and …
Matched Salts name: … Epinastine hydrochloride …
Matched Categories: … Decongestants and Antiallergics …
Matched Products: … Epinastine Hydrochloride ... RELESTAT (EPINASTINE HYDROCHLORIDE OPHTHALMIC SOLUTION 0.5 MG/ML) ... RELESTAT (EPINASTINE HYDROCHLORIDE OPTHALMIC SOLUTION) 0.5mg/ml …

Butenafine

Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols. In particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes.
Approved
Matched Description: … Butenafine hydrochloride is a synthetic benzylamine antifungal agent. …
Matched Salts name: … Butenafine hydrochloride …
Matched Products: … Butenafine Hydrochloride 1% ... Butenafine Hydrochloride ... Butenafine Hydrochloride Jock Itch …

Epimedium grandiflorum top

Epimedium grandiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Epimedium Grandiflorum Leaf/stem …

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate...
Approved
Matched Description: … An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment ... It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. ... Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively …
Matched Salts name: … Molindone hydrochloride …
Matched Products: … Molindone Hydrochloride …

Daunorubicin

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Approved
Matched Description: … , used in treatment of leukemia and other neoplasms. ... A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others …
Matched Salts name: … Daunorubicin hydrochloride …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... cytarabine and daunorubicin ... Cytotoxic Antibiotics and Related Substances …
Matched Products: … Daunorubicin Hydrochloride ... Daunorubicin Hydrochloride Injection ... Daunorubicin Hydrochloride for Injection …

Mecamylamine

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Approved
Investigational
Matched Description: … A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain …
Matched Salts name: … Mecamylamine hydrochloride …
Matched Categories: … Secondary and Tertiary Amines …
Matched Products: … Mecamylamine Hydrochloride …

Alosetron

Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer...
Approved
Withdrawn
Matched Description: … Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal ... reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and …
Matched Salts name: … Alosetron hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Alosetron Hydrochloride …

MIV-711

Investigational
Matched Synonyms: … -4-yl]-4-methyl-1-oxopentan-2-yl]-4-[5-fluoro-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide hydrochloride …

Isoprenaline

Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising...
Approved
Investigational
Matched Description: … anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and ... found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and ... [A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and …
Matched Salts name: … Isoprenaline hydrochloride …
Matched Categories: … Adrenergic and Dopaminergic Agents ... isoprenaline and other drugs for obstructive airway diseases …
Matched Products: … Isoproterenol Hydrochloride ... Isoproterenol hydrochloride ... Isoproterenol Hydrochloride Injection USP …

Imipramine

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … and clomipramine. ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... than secondary amine TCAs, such as nortriptyline and desipramine. …
Matched Salts name: … Imipramine hydrochloride …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Matched Products: … Imipramine Hydrochloride ... Imipramine hydrochloride ... Imipramine Hydrochloride Tablets 25mg …

Midodrine

An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Approved
Matched Salts name: … Midodrine hydrochloride …
Matched Categories: … Adrenergic and Dopaminergic Agents …
Matched Products: … Midodrine Hydrochloride ... Midodrine hydrochloride …

Trihexyphenidyl

Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant...
Approved
Matched Description: … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced ... [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment …
Matched Salts name: … Trihexyphenidyl hydrochloride …
Matched Products: … Trihexyphenidyl hydrochloride ... Trihexyphenidyl Hydrochloride ... TRIHEXYPHENIDYL HYDROCHLORIDE …

Dorzolamide

Dorzolamide is a non-bacteriostatic sulfonamide derivative and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension. It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. Unlike oral CA inhibitors, dorzolamide...
Approved
Matched Synonyms: … (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide …
Matched Description: … Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA ... ) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular ... [L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure …
Matched Mixtures name: … Dorzolamide Hydrochloride and Timolol Maleate ... Dorzolamide Hydrochloride and Timolol Maleate ... Dorzolamide Hydrochloride and Timolol Maleate …
Matched Salts name: … Dorzolamide hydrochloride …
Matched Categories: … Antiglaucoma Preparations and Miotics ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Dorzolamide Hydrochloride ... Dorzolamide hydrochloride ... Dorzolamide Hydrochloride Ophthalmic …

Ephedrine

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons,...
Approved
Matched Description: … [A193698] Ephedrine acts as both a direct and indirect sympathomimetic. ... It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of ... norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine …
Matched Salts name: … Ephedrine hydrochloride …
Matched Categories: … Adrenergic and Dopaminergic Agents ... Alimentary Tract and Metabolism ... Alpha-and Beta-adrenergic Agonists ... Epinephrine and similars ... Herbs and Natural Products …
Matched Products: … EPHEDRINE HYDROCHLORIDE ... Ephedrine Hydrochloride ... Ephedrine Hydrochloride Tablets 25mg …

Yohimbine

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Approved
Investigational
Vet approved
Matched Description: … Yohimbine has been used as a mydriatic and in the treatment of impotence. …
Matched Salts name: … Yohimbine hydrochloride …
Matched Categories: … Genito Urinary System and Sex Hormones …
Matched Products: … Yohimbine Hydrochloride Tab 2mg ... Yohimbine Hydrochloride Tablets 5.4mg …

Meperidine

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Description: … with morphine and are of shorter duration. ... that can be used for the relief of most types of moderate to severe pain, including postoperative pain and ... Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than …
Matched Mixtures name: … Meperidine Hydrochloride and Promethazine Hydrochloride ... Meperidine Hcl and Promethazine Hcl …
Matched Salts name: … Meperidine hydrochloride …
Matched Categories: … pethidine and antispasmodics …
Matched Products: … Meperidine Hydrochloride ... Meperidine Hydrochloride Injection USP ... DBL PETHIDINE HYDROCHLORIDE INJECTION BP 50mg/ml …
Displaying drugs 576 - 600 of 878 in total