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Displaying drugs 126 - 150 of 375 in total

Dexmethylphenidate

Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002 . It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant . It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or...
Approved
Investigational
Matched Synonyms: … methyl (R)-phenyl[(R)-piperidin-2-yl]acetate …
Matched Iupac: … methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate …
Matched Description: … Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. ... It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. …
Matched Categories: … Methylphenidate and isomer ... dexmethylphenidate and serdexmethylphenidate ... Psychostimulants, Agents Used for ADHD and Nootropics …

Sotorasib

Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Synonyms: … 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl …
Matched Iupac: … 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop …
Matched Description: … [A187547] The drug [MRTX849] is also currently being developed and has the same target. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Levocetirizine

Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine. Levocetirizine was granted FDA approval in 1995.
Approved
Matched Synonyms: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Iupac: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Categories: … Cetirizine and isomer …

Tibolone

Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha . Tibolone (Livial, Org OD 14), produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic...
Approved
Investigational
Matched Synonyms: … 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one …
Matched Description: … produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic and ... Tibolone is approved in 90 countries to manage menopausal symptoms and in 45 countries to prevent the ... been used in Europe for almost 2 decades, primarily for the prevention of postmenopausal osteoporosis and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Estrogens, Antiestrogens, and Estrogen Agonist-Antagonists …

Olutasidenib

Olutasidenib (FT-2102) is a selective and potent isocitrate dehydrogenase-1 (IDH1) inhibitor approved by the FDA in December 2022.[L44256,L44261] It is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML) in patients with a susceptible IDH1 mutation as determined by an FDA-approved test. IDH1 mutations are common in...
Approved
Investigational
Matched Synonyms: … (s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2- ... 5-(((1s)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2 ... pyridinecarbonitrile, 5-(((1s)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl)amino)-1,6-dihydro-1-methyl …
Matched Iupac: … 5-{[(1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-1-methyl-6-oxo-1,6-dihydropyridine-2 …
Matched Description: … and gliomas (NCT03684811). ... Olutasidenib (FT-2102) is a selective and potent isocitrate dehydrogenase-1 (IDH1) inhibitor approved ... in different types of cancer, such as gliomas, AML, intrahepatic cholangiocarcinoma, chondrosarcoma, and …

Cefepime

Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against both compared to third-generation antibiotics.[A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused by multi-resistant microorganisms such as Pseudomonas aeruginosa, and is also indicated...
Approved
Investigational
Matched Synonyms: … -7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl …
Matched Iupac: … thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl …
Matched Description: … Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against ... [A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused ... by multi-resistant microorganisms such as _Pseudomonas aeruginosa_, and is also indicated for the empirical …
Matched Categories: … cefepime and amikacin …
Matched Products: … Cefepime Hydrochloride and Dextrose …

Cinacalcet

Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Approved
Matched Synonyms: … (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine …
Matched Description: … and as Mimpara® in Europe. ... Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia …
Matched Categories: … Sex Hormones and Insulins ... Calcium-Regulating Hormones and Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Valaciclovir

Valaciclovir (valacyclovir), also known as Valtrex, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline . Valacyclovir is the L-valine ester of aciclovir. It...
Approved
Investigational
Matched Synonyms: … L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine …
Matched Description: … It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline [L5671]. ... Valaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and ... This class of drugs forms an important part of hepatitis, HIV, and cytomegalovirus drug regimens [A175900 …
Matched Categories: … Acyclovir and prodrug ... Nucleosides and Nucleotides ... Amino Acids, Peptides, and Proteins ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Hydromorphone

Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and...
Approved
Illicit
Matched Synonyms: … 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone …
Matched Iupac: … (1S,5R,13R,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca- …
Matched Description: … [A176495] The first reported approved product containing hydromorphone in the form of hydromorphone ... the absence of a double bond between the carbon 7 and 8. ... hydrochloride was developed by Fresenius Kabi USA and FDA approved in 1984. …
Matched Categories: … hydromorphone and naloxone ... hydromorphone and antispasmodics …

Mepyramine

Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication...
Approved
Vet approved
Matched Synonyms: … N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine …
Matched Iupac: … N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine …
Matched Description: … However, it rapidly permeates the brain and so often causes drowsiness as a side effect. ... It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered …
Matched Mixtures name: … Acetaminophen,Caffeine and Pyrilamine Maleate ... Pyrilamine Maleate and Phenylephrine Hydrochloride …
Matched Categories: … Hypnotics and Sedatives …

Eszopiclone

Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as cyclopyrrolones.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity , offering a safer alternative to other drugs used...
Approved
Investigational
Matched Synonyms: … 1-Piperazinecarobxylic acid,4-methyl-,(5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4- ... (S)-6-(5-Chloro-2-pyridinyl)- 7-oxo- 6,7-dihydro- 5H-pyrrolo[3,4-b]pyrazin-5-yl- 4-methyl- 1-piperazinecarboxylate …
Matched Description: … [A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity[A179827], offering a …
Matched Categories: … Hypnotics and Sedatives ... Zopiclone and prodrugs ... Benzodiazepine hypnotics and sedatives ... Miscellaneous Anxiolytics Sedatives and Hypnotics …

Levonorgestrel

Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices...
Approved
Investigational
Matched Synonyms: … 17-Ethynyl-18-methyl-19-nortestosterone ... 18-Methyl-17-alpha-ethynyl-19-nortestosterone …
Matched Description: … Some of these devices are known as Jaydess, Kyleena, and Mirena. ... Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone ... [A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as …
Matched Mixtures name: … Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol …
Matched Categories: … levonorgestrel and estrogen ... levonorgestrel and estrogen ... levonorgestrel and ethinylestradiol ... levonorgestrel and ethinylestradiol ... Genito Urinary System and Sex Hormones …
Matched Products: … ONE-AND-ONE …

Cannabidiol

Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact...
Approved
Investigational
Matched Synonyms: … (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydrobiphenyl-2,6-diol …
Matched Iupac: … 2-[(1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol …
Matched Description: … If not provided in their activated form (such as through synthetic forms of THC like [DB00470] or [DB00486 ... , and physiological effects. ... 2 (CB1 and CB2)[A32585,A32824]. …
Matched Categories: … Cannabinoids and similars …

Adagrasib

Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations. However, the development of KRAS inhibitors has been challenging due to their high affinity for guanosine triphosphate (GTP) and guanosine diphosphate...
Approved
Investigational
Matched Synonyms: … 2-piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2s)-1-methyl-2-pyrrolidinyl …
Matched Description: … KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations ... of KRAS inhibitors has been challenging due to their high affinity for guanosine triphosphate (GTP) and ... Adagrasib targets KRASG12C, one of the most common KRAS mutations, at the cysteine 12 residue and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Guaiacol

Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the...
Approved
Matched Description: … Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. ... Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma. ... Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. …
Matched Categories: … Methyl Ethers …

Choline

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Approved
Nutraceutical
Matched Description: … It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and ... A basic constituent of lecithin that is found in many plants and animal organs. …
Matched Mixtures name: … Palm Spring's PM Form Tab ... Revit Multi-vitamins and Minerals ... Choline and Inositol 250mg/250mg …
Matched Categories: … Salicylic Acid and Derivatives …

Cystine

A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Approved
Nutraceutical
Matched Description: … Two molecules of cysteine are joined together by a disulfide bridge to form cystine. …
Matched Mixtures name: … Medi Msm (methyl Sulfonyl Methane) …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Cetirizine

Cetirizine, also commonly known as Zyrtec, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called allergic...
Approved
Matched Iupac: … 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Description: … with sleep, and other difficulties with day to day activities for many individuals [A175057]. ... in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and ... prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and …
Matched Mixtures name: … ZYRTEC D Allergy and Congestion ... Wal Zyr D Allergy and Congestion ... Cetirizine HCl and Pseudoephedrine HCl ER …
Matched Categories: … Cetirizine and isomer ... Decongestants and Antiallergics …
Matched Products: … Up and Up Allergy Relief ... Up and Up All Day Allergy Relief ... Up and Up Childrens Allergy Relief …

Leucovorin

Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the...
Approved
Matched Iupac: … (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido …
Matched Description: … form while the dextro form is slowly excreted by the kidneys. ... In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate ... Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary …
Matched Categories: … Enzymes and Coenzymes ... Folic Acid and Derivatives …

Ketamine

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor...
Approved
Vet approved
Matched Description: … it produced minor hallucinogenic effects and shorter psychotomimetic effects. ... It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, ... It was FDA approved in 1970, and from there, it has been used as an anesthetic for children or patients …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Hydrocodone

Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone...
Approved
Illicit
Investigational
Matched Iupac: … (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca- …
Matched Description: … a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and ... Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is …
Matched Mixtures name: … Hydrocodone Bitartrate and Acetaminophen ... Hydrocodone Bitartrate and Acetaminophen ... Hydrocodone Bitartrate and Acetaminophen …
Matched Categories: … Cough and Cold Preparations ... Opium Alkaloids and Derivatives …
Matched Products: … Hydrocodone Bitartrate and Acetaminophen ... Hydrocodone Bitartrate And Acetaminophen …

Cerivastatin

On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.[A669,L43942]
Approved
Withdrawn
Matched Description: … Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew …

Cysteine

A thiol-containing non-essential amino acid that is oxidized to form cystine.
Approved
Nutraceutical
Matched Description: … A thiol-containing non-essential amino acid that is oxidized to form cystine. …
Matched Mixtures name: … Medi Msm (methyl Sulfonyl Methane) …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Cefamandole nafate

Approved
Matched Iupac: … (6R,7R)-7-[(2R)-2-(formyloxy)-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl …

Aliskiren

Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in...
Approved
Investigational
Matched Iupac: … }-8-methyl-2-(propan-2-yl)nonanamide ... 5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl …
Matched Description: … [A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. ... Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension …
Matched Categories: … Methyl Ethers ... valsartan and aliskiren ... aliskiren and amlodipine ... aliskiren and hydrochlorothiazide ... aliskiren, amlodipine and hydrochlorothiazide …
Displaying drugs 126 - 150 of 375 in total