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Displaying drugs 151 - 175 of 358 in total

Aurothioglucose

Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased since the 1980s...
Approved
Withdrawn
Matched Description: … use of gold compounds has decreased since the 1980s owing to numerous side effects, limited efficacy, and ... Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and ... replaced with the use of various current disease modifying anti-rheumatic drugs (DMARDs) like methotrexate and …
Matched Categories: … Antiinflammatory and Antirheumatic Products …

Prednicarbate

Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a...
Approved
Investigational
Matched Description: … The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin ... IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Gadoteridol

Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to disrupt the normal blood-brain barrier.[A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs)...
Approved
Investigational
Matched Description: … Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and …

Enasidenib

Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible for this treatment...
Approved
Investigational
Matched Description: … Food and Drug Administration on August 1, 2017. ... First developed by Agios Pharmaceuticals and licensed to Celgene, enasidenib was approved by U.S. ... This small molecule acts as an allosteric inhibitor of mutant IDH2 enzyme to prevent cell growth, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Enzacamene

Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reproductive system as an endocrine disruptor are being investigated, its use in...
Approved
Matched Description: … Its tradenames include Eusolex 6300 (Merck) and Parsol 5000 (DSM). ... Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic ... human reproductive system as an endocrine disruptor are being investigated, its use in over-the-counter and …
Matched Mixtures name: … Natural Sun AQ Body and Family Mild Sun Milk ... Outback 2-in-1 Insect Repellent and Protective Sunscreen ... mesoestetic moisturizing sun protection BROAD SPECTRUM FOR NORMAL AND DRY SKINS …

Nadolol

Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects. Nadolol...
Approved
Matched Description: … treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and …
Matched Mixtures name: … Nadolol and Bendroflumethiazide ... Nadolol and Bendroflumethiazide ... Nadolol and Bendroflumethiazide …
Matched Categories: … nadolol and thiazides ... Beta Blocking Agents and Thiazides ... Beta Blocking Agents, Non-Selective, and Thiazides …

Amcinonide

Amcinonide is a corticosteroid.
Approved
Matched Categories: … Hyperglycemia-Associated Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Dienogest

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not...
Approved
Matched Description: … Dienogest is commonly marketed as Visanne, Natazia and Qlaira. ... It is a derivative of 19-nortestosterone and has antiandrogenic properties. ... in combination with ethinylestradiol, or in other combination form pills approved in United States and …
Matched Mixtures name: … Estradiol Valerate and Estradiol Valerate/Dienogest ... Estradiol Valerate and Estradiol Valerate/Dienogest …
Matched Categories: … Hyperglycemia-Associated Agents ... dienogest and estrogen ... dienogest and estradiol ... dienogest and ethinylestradiol ... Genito Urinary System and Sex Hormones …

Fluticasone furoate

Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label] . Fluticasone furoate was first approved in 2007 .
Approved
Matched Description: … Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various …
Matched Mixtures name: … Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … Hyperglycemia-Associated Agents ... vilanterol and fluticasone furoate ... vilanterol, umeclidinium bromide and fluticasone furoate …

Pipradrol

Pipradrol (Meratran) was initially developed in the 1950s as an antidepressant, however, the adverse effects associated with its use and its abuse potential led to its withdrawal and international regulation . Pipradrol was made illegal in many countries in 1970s because of its potential for abuse. It is currently classified...
Approved
Matched Description: … Meratran) [L2523] was initially developed in the 1950s as an antidepressant, however, the adverse effects associated ... with its use and its abuse potential led to its withdrawal and international regulation [L2524]. ... acute toxicity and has been linked to three fatalities. …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Celecoxib

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in...
Approved
Investigational
Matched Description: … [A181544] It is used to manage symptoms of various types of arthritis pain and in familial adenomatous ... [A181532] It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval ... selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and …
Matched Categories: … Methemoglobinemia Associated Agents ... tramadol and celecoxib ... amlodipine and celecoxib ... Antiinflammatory and Antirheumatic Products ... Genito Urinary System and Sex Hormones …

Cyclosporine

Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products...
Approved
Investigational
Vet approved
Matched Description: … treat various inflammatory and autoimmune conditions. ... calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and ... [A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Metformin

Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin...
Approved
Matched Description: … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management ... It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and ... [A36559] Metformin was first approved in Canada in 1972,[A36552] and received subsequent FDA approval …
Matched Mixtures name: … Glyburide and Metformin ... Glyburide and Metformin ... Glyburide and Metformin …
Matched Categories: … metformin and acarbose ... Alimentary Tract and Metabolism ... metformin and evogliptin ... metformin and gemigliptin ... metformin and linagliptin …

Atorvastatin

Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Description: … [A181087,A181553] Several landmark studies demonstrate that the use of statins is associated with both ... a reduction in LDL levels and CVD risk. ... Bruce Roth and approved by the FDA in 1996. …
Matched Mixtures name: … Amlodipine and atorvastatin ... Amlodipine and atorvastatin ... Amlodipine and atorvastatin …
Matched Categories: … atorvastatin and ezetimibe ... atorvastatin and amlodipine ... atorvastatin and perindopril ... atorvastatin, amlodipine and ramipril ... atorvastatin and acetylsalicylic acid …

Fluocortolone

Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Approved
Withdrawn
Matched Categories: … Hyperglycemia-Associated Agents ... Sex Hormones and Insulins ... fluocortolone and antibiotics ... fluocortolone and antiseptics ... fluocortolone and antiinfectives …

Selumetinib

Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating earlier developed MEK inhibitors were underwhelming. However,...
Approved
Investigational
Matched Description: … tumours and is linked to other positive clinical outcomes. ... [A193608] Luckily, the use of selumetinib in patients with NF-1 have shown efficacy in shrinking associated ... [A193611] However, selumetinib demonstrated impressive efficacy and tolerability in Phase I trials, leading …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Sodium ferric gluconate complex

Sodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography. It is composed of iron (III) oxide hydrate directly bonded to sucrose...
Approved
Matched Description: … ) receiving hemodialysis and receiving supplemental epoetin therapy. ... It is used in adult and in pediatric patients over the age of 6 years with chronic kidney disease (CKD …

Canagliflozin

Canagliflozin, also known as Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018...
Approved
Matched Description: … It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 ... inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and canagliflozin …

Sirolimus

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Description: … FDA in April 2022: this marks the first topical treatment approved in the US for facial angiofibroma associated ... extensively investigated as an immunosuppressive and antitumour agent. ... [A242412] It was first isolated and identified as an antifungal agent with potent anticandida activity …
Matched Categories: … Hyperglycemia-Associated Agents ... Sirolimus and Prodrugs ... Antineoplastic and Immunomodulating Agents …

Beclomethasone dipropionate

Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to dexamethasone. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Beclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is...
Approved
Investigational
Matched Description: … beclomethasone dipropionate remains active locally in the lung without causing significant side effects associated ... later in a dry powder inhaler and an aqueous nasal spray. ... Beclomethasone dipropionate is a second-generation[A179842] synthetic corticosteroid and diester of beclomethasone …
Matched Mixtures name: … Ibicar S (Salbutamol 100 mcg/actuation and Beclometasone 50 mcg/actuation) Pressurised Inhalation …
Matched Categories: … Hyperglycemia-Associated Agents ... Alimentary Tract and Metabolism ... formoterol and beclometasone ... salbutamol and beclometasone ... beclometasone and antibiotics …

Olmesartan

Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, valsartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Description: … Olmesartan is commonly used for the management of hypertension and Type 2 Diabetes-associated nephropathy ... In particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate ... aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. …
Matched Mixtures name: … Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil …
Matched Categories: … olmesartan medoxomil and diuretics ... olmesartan medoxomil and amlodipine ... Angiotensin II Antagonists and Calcium Channel Blockers ... Angiotensin II receptor blockers (ARBs) and diuretics ... olmesartan medoxomil, amlodipine and hydrochlorothiazide …

Lactulose

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and ... [L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become ... List of Essential Medicines as one of the most effective and safe medicines employed in a health system …
Matched Categories: … Alimentary Tract and Metabolism …

Pitavastatin

Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Description: … lipid levels and ultimately reduce the risk of cardiovascular disease. ... studies to significantly reduce the risk of development of CVD and all-cause mortality. ... inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and …

Buprenorphine

Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.[A186283,A186292] It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is...
Approved
Illicit
Investigational
Vet approved
Matched Description: … injection supplies in an effort to reduce the risks associated with injection drug use which includes ... contraction of HIV and Hepatitis C and other complications including skin infections, abscesses, or ... who require larger and more frequent doses. …
Matched Mixtures name: … Buprenorphine and Naloxone ... Buprenorphine and Naloxone ... Buprenorphine and Naloxone …

Isavuconazonium

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it...
Approved
Investigational
Matched Description: … posaconazole, eliminating concerns of nephrotoxicity associated with cyclodextrin. ... [A38834] It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and ... Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July …
Matched Categories: … Isavuconazole and Prodrugs …
Displaying drugs 151 - 175 of 358 in total