Displaying drugs 226 - 250 of 1034 in total
Iron Dextran
Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.
Approved
Vet approved
Matched Description: … Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous …
Matched Mixtures name: … Threonate and Succinic Acid ... Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium …
Matched Products: … Cosmofer 50mg/ml Solution for injection and for infusion …
Matched Mixtures name: … Threonate and Succinic Acid ... Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium …
Matched Products: … Cosmofer 50mg/ml Solution for injection and for infusion …
Ergidina
Ergidina is a recombinant human minibody against complement component C5 fused with RGD-motif.
Investigational
Matched Synonyms: … Neutralizing scFv dimer to C5 fused at the C terminal end to the Fc domains of human IgG1 and the cyclic …
Haemophilus influenzae type B strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen
Haemophilus influenzae type b strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen is an active immunization as a booster dose given intramuscularly to pediatric patients who have received a primary series with a Haemophilus b Conjugate Vaccine that is licensed for primarly immunization. The vaccine contains Haemophilus b capsular polysaccharide...
Approved
Investigational
Matched Synonyms: … Haemophilus influenzae type B-PRP and tetanus toxoid conjugate (PRP-T) …
Matched Description: … These are heat inactivated and purified. ... The vaccine contains Haemophilus b capsular polysaccharide (polyribosyl-ribitol-phosphate [PRP]), which …
Matched Description: … These are heat inactivated and purified. ... The vaccine contains Haemophilus b capsular polysaccharide (polyribosyl-ribitol-phosphate [PRP]), which …
Apadamtase alfa
Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Synonyms: … Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs …
Matched Description: … rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and ... Patients with cTTP have a severe deficiency of a plasma metalloproteinase called ADAMTS13 (a disintegrin and ... thrombospondin type 1 motif, member 13), which is responsible for cleaving large von Willebrand factor multimers and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Blood and Blood Forming Organs ... apadamtase alfa and cinaxadamtase alfa …
Matched Description: … rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and ... Patients with cTTP have a severe deficiency of a plasma metalloproteinase called ADAMTS13 (a disintegrin and ... thrombospondin type 1 motif, member 13), which is responsible for cleaving large von Willebrand factor multimers and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Blood and Blood Forming Organs ... apadamtase alfa and cinaxadamtase alfa …
Miconazole
Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027,...
Approved
Investigational
Vet approved
Matched Description: … [A203636] It is widely used to treat mucosal yeast infections, including both oral and vaginal infections ... although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and ... [A203636, A203639]
Miconazole was first synthesized in 1969 and first granted FDA approval on January …
Matched Mixtures name: … Up and Up Miconazole 1 ... Up and Up Miconazole 1 ... Up and Up Miconazole 1 …
Matched Categories: … Antiinfectives and Antiseptics for Local Oral Treatment ... Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Vaginal Creams, Foams, and Jellies ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Up and Up Miconazole 7 ... Soothe And Cool Treat ... Up and Up Jock Itch Relief …
Matched Mixtures name: … Up and Up Miconazole 1 ... Up and Up Miconazole 1 ... Up and Up Miconazole 1 …
Matched Categories: … Antiinfectives and Antiseptics for Local Oral Treatment ... Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Vaginal Creams, Foams, and Jellies ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Up and Up Miconazole 7 ... Soothe And Cool Treat ... Up and Up Jock Itch Relief …
Cetrorelix
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not...
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Cetrotide 0.25 mg powder and solvent for solution for injection …
Matched Products: … Cetrotide 0.25 mg powder and solvent for solution for injection …
Capsicum
Capsicum (Chili pepper) allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Louisiana sport pepper …
Matched Mixtures name: … Zaxs Aches and Pain …
Matched Products: … SinolM Fast Allergy and Sinus Relief All-Natural Nasal …
Matched Mixtures name: … Zaxs Aches and Pain …
Matched Products: … SinolM Fast Allergy and Sinus Relief All-Natural Nasal …
Tolnaftate
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
Approved
Investigational
Vet approved
Matched Description: … and ringworm. ... It is sold under several brand names, most notably Tinactin and Odor Eaters. ... It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot …
Matched Mixtures name: … Terbinafine HCl Chlortimazole and Tolnaftate …
Matched Products: … Up and Up Antifungal ... Up and Up Soothing Antifungal ... Fungi Nail Toe and Foot …
Matched Mixtures name: … Terbinafine HCl Chlortimazole and Tolnaftate …
Matched Products: … Up and Up Antifungal ... Up and Up Soothing Antifungal ... Fungi Nail Toe and Foot …
Potassium chloride
A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.
The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of...
Approved
Withdrawn
Matched Synonyms: … Potassium chloride ... Chlorid draselny ... Chloride of potash …
Matched Name: … Potassium chloride …
Matched Iupac: … potassium chloride …
Matched Description: … chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage ... in fertilizers and explosives. ... crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and …
Matched Mixtures name: … Potassium Chloride in Dextrose and Sodium Chloride ... Potassium Chloride in Dextrose and Sodium Chloride ... Potassium Chloride in Dextrose and Sodium Chloride …
Matched Categories: … potassium chloride ... potassium chloride ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Potassium Chloride ... Potrassium Chloride ... Potassium Chloride ER …
Matched Name: … Potassium chloride …
Matched Iupac: … potassium chloride …
Matched Description: … chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage ... in fertilizers and explosives. ... crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and …
Matched Mixtures name: … Potassium Chloride in Dextrose and Sodium Chloride ... Potassium Chloride in Dextrose and Sodium Chloride ... Potassium Chloride in Dextrose and Sodium Chloride …
Matched Categories: … potassium chloride ... potassium chloride ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Potassium Chloride ... Potrassium Chloride ... Potassium Chloride ER …
Potassium carbonate
Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. It presents a large capacity to absorb moisture.
Approved
Matched Synonyms: … Potassium carbonate ... Potassium carbonate, anhydrous …
Matched Name: … Potassium carbonate …
Matched Description: … It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. ... Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly …
Matched Mixtures name: … Vit C W Calc-mag and Potass Powder ... Buffered Vitamin C Powder With Ca Mg and K ... ZOLFO E POTASSIO CARBONATO NEW.FA.DEM. …
Matched Categories: … Potassium Salt …
Matched Products: … Moonstar Face and Body Mist …
Matched Name: … Potassium carbonate …
Matched Description: … It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. ... Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly …
Matched Mixtures name: … Vit C W Calc-mag and Potass Powder ... Buffered Vitamin C Powder With Ca Mg and K ... ZOLFO E POTASSIO CARBONATO NEW.FA.DEM. …
Matched Categories: … Potassium Salt …
Matched Products: … Moonstar Face and Body Mist …
Glycerin
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Approved
Investigational
Matched Description: … A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. …
Matched Mixtures name: … Skinfood Real Tea Ge L Mask Chamomile ... Correct Essential Activator ... Cellisys EX EGF Wrinkle 29 Activator …
Matched Categories: … Alimentary Tract and Metabolism ... Basic Ointments and Protectants ... Other Cold and Cough Preparations …
Matched Products: … MEDICLEAR DUAL SPOT DAY and NIGHT ... Carrot Seed Oi L Calming Mask 7days ... Soothing and Moisture Aloe Vera 90 Percent Toner …
Matched Mixtures name: … Skinfood Real Tea Ge L Mask Chamomile ... Correct Essential Activator ... Cellisys EX EGF Wrinkle 29 Activator …
Matched Categories: … Alimentary Tract and Metabolism ... Basic Ointments and Protectants ... Other Cold and Cough Preparations …
Matched Products: … MEDICLEAR DUAL SPOT DAY and NIGHT ... Carrot Seed Oi L Calming Mask 7days ... Soothing and Moisture Aloe Vera 90 Percent Toner …
Eugenol
Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Although not currently available in any FDA-approved...
Approved
Matched Description: … for root canal sealing and pain control. ... Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and ... It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide …
Matched Products: … Walgreens Natural Eugenol/Toothache Medication with cotton pellets and tweezers …
Matched Products: … Walgreens Natural Eugenol/Toothache Medication with cotton pellets and tweezers …
Chamomile
Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Investigational
Matched Synonyms: … Matricaria Chamomilla Flower ... Matricaria Chamomilla Extract ... Chamomilla Recutita (Matricaria) Flower …
Matched Name: … Chamomile …
Matched Description: … Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Products: … Chamomile 360mg ... Atorak Chamomile Atocare Pure ... Ethical Herbals Digestive Aid (chamomile Flower Extract) …
Matched Name: … Chamomile …
Matched Description: … Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Products: … Chamomile 360mg ... Atorak Chamomile Atocare Pure ... Ethical Herbals Digestive Aid (chamomile Flower Extract) …
Lidocaine
Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local...
Approved
Vet approved
Matched Description: … Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an ... , it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and ... It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues …
Matched Mixtures name: … Activate Joint and Muscle Relief ... Benzalkonium Chloride and Lidocaine Hydrochloride ... Benzalkonium Chloride and Lidocaine Hydrochloride …
Matched Categories: … Analgesics and Anesthetics ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Antipruritics and Local Anesthetics ... Sodium Channel Blockers ... Voltage-Gated Sodium Channel Blockers …
Matched Products: … BENGAY Ginger Citrus ... Terrasil Rash and Pain Relief ... Terrasil Itch, Rash and Pain Relief MAX …
Matched Mixtures name: … Activate Joint and Muscle Relief ... Benzalkonium Chloride and Lidocaine Hydrochloride ... Benzalkonium Chloride and Lidocaine Hydrochloride …
Matched Categories: … Analgesics and Anesthetics ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Antipruritics and Local Anesthetics ... Sodium Channel Blockers ... Voltage-Gated Sodium Channel Blockers …
Matched Products: … BENGAY Ginger Citrus ... Terrasil Rash and Pain Relief ... Terrasil Itch, Rash and Pain Relief MAX …
Glyceryl monostearate
Glycerol monostearate, commonly known as GMS, is the glycerol ester of stearic acid . It is commonly used as an emulsifier in foods.
Experimental
Matched Synonyms: … Geleol mono and diglycerides …
Lawsonia inermis leaf
Lawsonia inermis leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Plants and Plant Parts, Henna Lawsonia Inermis …
Triptorelin
Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels...
Approved
Vet approved
Matched Description: … and testicular and ovarian steroidogenesis. ... After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 11.25 mg/vial ... POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 3.75 mg/vial …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 11.25 mg/vial ... POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 3.75 mg/vial …
Tilmicosin
Tilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
Investigational
Vet approved
Matched Description: … It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory …
Matched Salts name: … Tilmicosin phosphate …
Matched Products: … Tilmovet® 200 g/kg Premix for Medicated Feeding Stuff for Pigs and Rabbits ... TP-Mecotil 300 Sol Tilmicosin Phosphate 300mg/ml Solution …
Matched Salts name: … Tilmicosin phosphate …
Matched Products: … Tilmovet® 200 g/kg Premix for Medicated Feeding Stuff for Pigs and Rabbits ... TP-Mecotil 300 Sol Tilmicosin Phosphate 300mg/ml Solution …
Hydrocortisone
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone was granted FDA approval on 5 August 1952.
Approved
Vet approved
Matched Description: … [A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. ... [L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named …
Matched Mixtures name: … Odan-spor-HC ... Neomycin and Polymyxin B Sulfates and Hydrocortisone ... Neomycin and Polymyxin B Sulfates and Hydrocortisone …
Matched Categories: … Medications that reduce magnesium levels ... Alimentary Tract and Metabolism ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Sex Hormones and Insulins ... Hydrocortisone and derivatives …
Matched Products: … Rodan and Fields Soothe ... Itch and Rash Cream ... meijer Itch and Rash Relief …
Matched Mixtures name: … Odan-spor-HC ... Neomycin and Polymyxin B Sulfates and Hydrocortisone ... Neomycin and Polymyxin B Sulfates and Hydrocortisone …
Matched Categories: … Medications that reduce magnesium levels ... Alimentary Tract and Metabolism ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Sex Hormones and Insulins ... Hydrocortisone and derivatives …
Matched Products: … Rodan and Fields Soothe ... Itch and Rash Cream ... meijer Itch and Rash Relief …
Aluminum zirconium tetrachlorohydrex gly
Aluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent. Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.
Approved
Matched Description: … Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing …
Matched Products: … Ap 22% (regular,sport,musk and Unscented) ... Mitchum Clear Gel A.P. and Deod.supersport ... Body Satin Antiperspirant and Deodorant …
Matched Products: … Ap 22% (regular,sport,musk and Unscented) ... Mitchum Clear Gel A.P. and Deod.supersport ... Body Satin Antiperspirant and Deodorant …
Biotin
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
Approved
Investigational
Nutraceutical
Matched Description: … and milk. ... It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, …
Matched Mixtures name: … AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass ... Kanga Sport Vitamins B & C Plus Minerals ... Therapytion Nokmosu Sensitive and Dry Hair …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition ... Enzymes and Coenzymes …
Matched Products: … Biona-vit Controls and Prevents Hair Loss ... Bonogen Activator hair loss treatment …
Matched Mixtures name: … AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass ... Kanga Sport Vitamins B & C Plus Minerals ... Therapytion Nokmosu Sensitive and Dry Hair …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition ... Enzymes and Coenzymes …
Matched Products: … Biona-vit Controls and Prevents Hair Loss ... Bonogen Activator hair loss treatment …
Clindamycin
Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli. Interestingly,...
Approved
Vet approved
Matched Description: … bacilli and gram-negative bacilli. ... used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. ... relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and …
Matched Mixtures name: … Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025% ... Clindamycin Phosphate and Tretinion ... Clindamycin Phosphate and Benzoyl Peroxide …
Matched Salts name: … Clindamycin phosphate …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Macrolides, Lincosamides and Streptogramins …
Matched Products: … Clindamycin Phosphate ... Cleocin Phosphate ... Clindamycin phosphate …
Matched Mixtures name: … Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025% ... Clindamycin Phosphate and Tretinion ... Clindamycin Phosphate and Benzoyl Peroxide …
Matched Salts name: … Clindamycin phosphate …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Macrolides, Lincosamides and Streptogramins …
Matched Products: … Clindamycin Phosphate ... Cleocin Phosphate ... Clindamycin phosphate …
Calcium ascorbate
Approved
Nutraceutical
Matched Mixtures name: … C-1000 Plus Zinc & Potassium ... and Succinic Acid ... Threonate and Succinic Acid …
Matched Categories: … Diet, Food, and Nutrition ... Vitamin C and analogues …
Matched Products: … Ester-C With Non-medicinal Bioflavonoids, Quercetin, and Grape Seed Extract …
Matched Categories: … Diet, Food, and Nutrition ... Vitamin C and analogues …
Matched Products: … Ester-C With Non-medicinal Bioflavonoids, Quercetin, and Grape Seed Extract …
Azercabtagene zapreleucel
Investigational
Matched Synonyms: … Adult allogeneic CD4+ and CD8+ enriched T cells transduced with an anti-CD19 chimeric antigen receptor ... Adult allogeneic CD4+ and CD8+ enriched T cells, gene edited through the electroporati …
Displaying drugs 226 - 250 of 1034 in total