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Displaying drugs 2601 - 2625 of 15133 in total

Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen

Neisseria meningitidis serogroup B recombinant lp2086 a05 protein variant antigen is a sterile vaccine for intramuscular injection indicated for the active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. It is contained in the suspension of Trumenba, which is a vaccine is composed of two recombinant lipidated...
Approved
Matched Description: … one from subfamily B (A05 and B01, respectively). ... factor H binding protein (fHBP) variants from N. meningitidis serogroup B, one from fHBP subfamily A and …

Zoledronate D,L-Lysine Monohydrate

Approved
Investigational
Matched Iupac: … 2,6-diaminohexanoic acid [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid hydrate …

Hydroxystilbamidine

Hydroxystilbamidine isethionate is used in the therapy of some patients with nonprogressive blastomycosis of the skin, and pulmonary or systemic blastomycosis in children, with fewer side effects than amphotericin B. Hydroxystilbamidine isethionate is also used in pathology for diagnostic purposes.
Approved
Matched Description: … isethionate is used in the therapy of some patients with nonprogressive blastomycosis of the skin, and …

Ceritinib

Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Description: … lymphoma kinase), which results in constitutive kinase activity that contributes to carcinogenesis and ... autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and ... rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Porfimer sodium

The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in...
Approved
Investigational
Matched Description: … photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Imelasomeran

Imelasomeran was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent COVID-19 mRNA vaccine. It encodes for the viral spike protein of the Omicron BA.1 variant of SARS-CoV-2, a particularly infectious variant of concern first documented in 2021.
Approved
Investigational

Rivastigmine

Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Approved
Investigational
Matched Description: … Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase …

Bethanechol

Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For example, bethanechol is readily used to treat postoperative or...
Approved
Matched Description: … [A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function ... to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system …

Human papillomavirus type 33 L1 capsid protein antigen

Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 33. The vaccine is prepared from the purified...
Approved
Matched Description: … It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused ... HPV Type 33 which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and …

Decamethonium

Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor.
Approved
Matched Description: … It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. …

Aluminum chlorohydrex propylene glycol

Aluminum chlorohydrex propylene glycol is a complex consisting of Aluminum Chorohydrate and propylene glycol (PG). It is an antiperspirant active ingredient found in antiperspirant drug products for over-the-counter human use.
Approved
Matched Description: … Aluminum chlorohydrex propylene glycol is a complex consisting of Aluminum Chorohydrate and propylene …

Dimercaprol

Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the past...
Approved
Matched Description: … It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. ... Dimercaprol has toxic potential, and its use may be followed by a variety of adverse effects. …

Doravirine

Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg). Doravirine is formally indicated for the treatment of...
Approved
Investigational
Matched Description: … adult patients with no prior antiretroviral treatment experience, further expanding the possibility and ... Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and …
Matched Categories: … lamivudine, tenofovir disoproxil and doravirine …

Foscarbidopa

Foscarbidopa is under investigation in clinical trial NCT04379050 (Extension Study to Evaluate Safety and Tolerability of 24-hour Daily Exposure of Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Parkinson's Disease).
Approved
Investigational
Matched Iupac: … (2S)-2-hydrazinyl-3-[3-hydroxy-4-(phosphonooxy)phenyl]-2-methylpropanoic acid …
Matched Description: … Foscarbidopa is under investigation in clinical trial NCT04379050 (Extension Study to Evaluate Safety and …

Methdilazine

Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Approved

Alosetron

Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer...
Approved
Withdrawn
Matched Description: … reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and ... Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal …
Matched Categories: … Alimentary Tract and Metabolism …

Copper Cu-64

Copper-64 is a radiopharmaceutical usually found in the +2 oxidation state as the complexes including the +1 state tend to be more unstable. It is used in molecular radiotherapy and positron emission tomography.
Approved
Matched Description: … [T604] It is used in molecular radiotherapy and positron emission tomography. …

Pemirolast

Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic...
Approved
Investigational
Matched Description: … pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and …

Davesomeran

Davesomeran is a mRNA vaccine used in conjunction with elasomeran as part of the Moderna Bivalent COVID-19 vaccine. Similar to the previous Moderna COVID-19 vaccine, Moderna Bivalent vaccine encodes the full-length pre-fusion stabilized spike (S) protein to elicit an immune response.[L43882,L28026] However, with the addition of davesomeran, Moderna Bivalent vaccine...
Approved
Investigational
Matched Description: … Bivalent vaccine elicit a higher seroresponse both against the original SARS-CoV-2 strain and the BA ... [L43882] A phase 2 and 3 open-label study in participants 18 years or older who had previously received ... a two-dose primary series and one booster dose of Moderna COVID-19 Vaccine demonstrated that the Moderna …

N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine

N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine is a component of black rubber. It is also a dermatological sensitizer and allergen. Sensitivity to N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine may be identified with a clinical patch test.
Approved
Matched Description: … It is also a dermatological sensitizer and allergen. …

Equine Botulinum Neurotoxin G Immune FAB2

Equine Botulinum Neurotoxin G Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype G. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes G in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes G in adults and …

Equine Botulinum Neurotoxin A Immune FAB2

Equine Botulinum Neurotoxin A Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype A. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes A in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes A in adults and …

Equine Botulinum Neurotoxin F Immune FAB2

Equine Botulinum Neurotoxin F Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype F. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes F in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes F in adults and …

Equine Botulinum Neurotoxin D Immune FAB2

Equine Botulinum Neurotoxin D Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype D. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes D in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes D in adults and …

Equine Botulinum Neurotoxin B Immune FAB2

Equine Botulinum Neurotoxin B Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype B. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes B in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes B in adults and …
Displaying drugs 2601 - 2625 of 15133 in total