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Displaying drugs 276 - 300 of 9509 in total

Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Description: … been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of ... It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin ... [L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Thiopental

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched Description: … of complete anesthesia of short duration. ... It is also used for hypnosis and for the control of convulsive states. ... A barbiturate that is administered intravenously for the induction of general anesthesia or for the production …
Matched Categories: … combinations of barbiturates …

Cyclobenzaprine

Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from Amitriptyline by only a single double bond.[A185039,A184982] Since its approval, it has...
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pizotifen

Pizotifen belongs to the class of antamines and is related to cyproheptadine. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties . Some patients receiving pizotifen...
Approved
Matched Description: … of its antimigraine action [A32538]. ... Pizotifen belongs to the class of antamines and is related to [cyproheptadine]. ... Sandomigran is available in a number of countries but is not approved by the FDA nor EMA. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Hydroxyzine

Hydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus. The active metabolite of hydroxyzine,...
Approved
Matched Description: … Hydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane ... in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect. ... [L9677] The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient …
Matched Products: … INDOLGIN (R) 0.25% JARABE. …

Vitamin A

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of carotenoids found in plants. It is enriched in...
Approved
Nutraceutical
Vet approved
Matched Description: … , the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune ... Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina ... Dietary vitamin A is derived from a variety of carotenoids found in plants. …
Matched Mixtures name: … Formula R Tab …

Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Approved
Investigational
Matched Description: … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast ... converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of …
Matched Products: … CORRETAL(R) 150 MG …

Desipramine

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive...
Approved
Investigational
Matched Description: … TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... See toxicity section below for a complete listing of side effects. ... Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Alprazolam

Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse...
Approved
Illicit
Investigational
Matched Description: … of the drug which may lead to coma and death. ... Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. ... [A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects …

Rose bengal

Rose bengal is a pink stain derived as an analogue of fluorescein. Its disodium salt in ophthalmic solutions has been used as a diagnostic agent in suspected damage to conjunctival and corneal cells. It is also used in laboratory settings, including the preparation of Foraminifera for microscopic analysis and suppression...
Approved
Investigational
Matched Description: … Rose bengal is a pink stain derived as an analogue of fluorescein. ... and suppression of bacterial growth in several microbiological media. ... The clinical applications of rose bengal as injectable formulation under the name PV-10 in melanoma, …

Dextropropoxyphene

Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the market in Europe...
Approved
Illicit
Investigational
Withdrawn
Matched Description: … It is used in the symptomatic treatment of mild pain. ... Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Fluspirilene

A long-acting injectable antipsychotic agent used for chronic schizophrenia.
Approved
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Elbasvir

Elbasvir is a direct-acting antiviral medication used as part of combination therapy to treat chronic hepatitis C, an infectious liver disease caused by infection with hepatitis C virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in...
Approved
Matched Description: … inhibitors, another class of DAAs. ... [synthesis] The barrier to the development of resistance to NS5A inhibitors is lower than that of NS5B ... reduced liver-related damage, improved quality of life, reduced incidence of hepatocellular carcinoma …
Matched Categories: … Antivirals for treatment of HCV infections …

Morphine

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength...
Approved
Investigational
Matched Description: … Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. ... [A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids ... A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pindolol

Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s....
Approved
Investigational
Matched Description: … focused on the treatment of arrhythmia. ... Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. ... [A231059] Research into pindolol's use in the treatment of hypertension began in the early 1970s. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Description: … Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. ... Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes …
Matched Categories: … combinations of sulfonamides …

Posaconazole

Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Approved
Investigational
Vet approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Dichlorobenzyl alcohol

Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other...
Approved
Matched Mixtures name: … ซีพาคอล(R) อาร์เอ็กซ์ ... ซีพาคอล(R) อาร์เอ็กซ์ …

Isoniazid

Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Approved
Investigational
Matched Description: … It remains the treatment of choice for tuberculosis. …
Matched Categories: … Drugs for Treatment of Tuberculosis ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Budesonide

Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product...
Approved
Matched Description: … of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. ... Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions …
Matched Products: … ENTOCORT(R)2 MG ... RHINOCORT (R) AQUA 64 MCG/DOSIS …

Topiramate

Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … In 2004, topiramate was approved for the prevention of migraine in adults. ... from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of …
Matched Products: … PIRAMAX(R) 100 MG …

Remimazolam

Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid...
Approved
Investigational
Matched Description: … Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation ... [L14647] Recent trends in anesthesia-related drug development have touted the benefits of so-called " ... [A214857] These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/ …

Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain . Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lynestrenol

Lynestrenol is a progestin and prodrug of norethisterone.
Approved
Investigational
Matched Description: … Lynestrenol is a progestin and prodrug of [norethisterone]. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Ketorolac

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain,...
Approved
Matched Description: … [L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making …
Matched Products: … KERADOL (R) TABLETAS 20 MG …
Displaying drugs 276 - 300 of 9509 in total