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Displaying drugs 3001 - 3025 of 3361 in total

Levosimendan

Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure.
Approved
Investigational
Matched Description: … Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent ... This increases contractility without raising calcium levels. …
Matched Products: … SIMDAX 2.5 MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION ... Simdax 2.5 mg/ml concentrate for solution for infusion. …

Technetium Tc-99m albumin colloid

Approved
Experimental
Matched Products: … Pulmolite, Kit for the Preparation of Technetium Tc99m Albumin Aggregated …

Clostridium botulinum

Experimental
Matched Products: … DYSPORT FOR INJECTION 300u/vial ... DYSPORT FOR INJECTION 500 u/vial ... NEURONOX LYOPHILIZED POWDER FOR INJECTION 100 UNITS/VIAL …

Methoxsalen

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Approved
Matched Synonyms: … 6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone …
Matched Description: … It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. …
Matched Categories: … Indicators and Reagents ... Antipsoriatics for Systemic Use ... Antipsoriatics for Topical Use ... Psoralens for Topical Use ... Psoralens for Systemic Use …

Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Approved
Investigational
Matched Synonyms: … 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide …
Matched Description: … belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and ... Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Leflunomide and metabolite …

PPI-1040

Investigational
Matched Synonyms: … 4,7,10,13,16,19-docosahexaenoic acid, 2-((1z)-1-hexadecen-1-yloxy)-1-(((2-oxido-1,3,2-oxazaphospholidin …

Scopolamine

Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine.[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine...
Approved
Investigational
Matched Synonyms: … alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester …
Matched Description: … diverse therapeutic applications; currently, it is approved for the prevention of nausea and vomiting ... nervous system and cholinergic signalling. ... tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and …
Matched Mixtures name: … Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide ... Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide …
Matched Categories: … Alimentary Tract and Metabolism ... Antiemetics and Antinauseants ... Hypnotics and Sedatives ... Mydriatics and Cycloplegics …

IDN-7314

Investigational
Matched Synonyms: … 2,6-difluorophenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid …
Matched Iupac: … [(2,6-difluorophenyl)carbamoyl]formamido}propanamido]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid …

Edaravone

Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. It has three tautomers. Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and cerebral ischemia.[A19140,L44007,A254257] The intravenous formulation of edaravone was first approved in Japan in...
Approved
Investigational
Matched Description: … Medicinal Products for Human Use (CHMP) for a long-term study demonstrating the long-term efficacy and ... [L44007] It was later approved for the treatment of amyotrophic lateral sclerosis (ALS) in Japan and ... Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. …
Matched Products: … RADICAVA™ IV Concentrate Solution for Infusion 30mg/20mL …

Hepatitis B immune globulin

Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. According to the Centers for Disease Control...
Approved
Investigational
Matched Description: … The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. ... According to the Centers for Disease Control and Prevention (CDC), the hepatitis B vaccine was the first ... During the process, viruses are deactivated, and in the final steps, solvents used in the preparation …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins ... Antiinfectives for Systemic Use …
Matched Products: … HEPATECT CP SOLUTION FOR INFUSION 50 IU/ML ... Niuliva Solution For Infusion 250 I.U./ml ... ZUTECTRA SOLUTION FOR INJECTION 500 IU/ML …

Prilocaine

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Approved
Matched Description: … Currently, it is used most often for infiltration anesthesia in dentistry. …
Matched Mixtures name: … TOPSY ... Citanest Forte ... Citanest Forte DENTAL …
Matched Products: … TAKIPRIL SOLUTION FOR INJECTION 20MG/ML ... Takipril 20mg/ml Solution for Injection …

Theophylline

A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly...
Approved
Matched Description: … mainly for asthma, bronchospasm, and COPD. ... Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated ... methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and …
Matched Mixtures name: … Theophylline 4mg and 5% Dextrose Inj ... Theophylline 1.6mg and 5% Dextrose Inj ... Theophylline 0.8mg and 5% Dextrose Inj …
Matched Categories: … Xanthines and Adrenergics ... theophylline and adrenergics ... Drugs for Obstructive Airway Diseases …
Matched Products: … TEOFILINA 200 MG CAPSULA RETARD ... AFPRED FORTE THEO 200MG ... BRONCHORETARD 500 FORTE …

Human cytomegalovirus immune globulin

Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human population, leading to infections which are followed by life-long...
Approved
Matched Description: … antibody for cytomegalovirus (CMV). ... CMV infection can lead to a high fever and severe organ-specific damage with significant morbidity and ... vaginal excretions, semen, breast milk and blood [L2228]. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins ... Antiinfectives for Systemic Use …
Matched Products: … MEGALOTECT CP SOLUTION FOR INFUSION 100 U/ML …

Nifuroxazide

Experimental
Matched Mixtures name: … METRO FORT ... STOMAVID NH CAPSULA DURA ... METRONIDAZOL BENZOILO/ NIFUROXAZIDA 250MG + 200MG/5 ML SUSPENSION …
Matched Categories: … Alimentary Tract and Metabolism ... Acids, Carbocyclic ... Hydroxy Acids ... Carboxylic Acids …
Matched Products: … DIAFURYL FORT 200 MG KAPSÜL, 16 ADET ... DIAFURYL FORT 200 MG KAPSÜL, 24 ADET …

Lovastatin

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Synonyms: … 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone …
Matched Description: … hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid ... Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite ... referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). …
Matched Categories: … lovastatin and nicotinic acid ... Hypolipidemic Agents Indicated for Hyperlipidemia …

Buloxibutid

Investigational
Matched Synonyms: … Carbamic acid, [[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl …

Technetium Tc-99m sestamibi

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by...
Approved
Investigational
Matched Description: … for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and ... infarction (non-reversible defects); and 2) evaluating myocardial function and developing information ... intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and …
Matched Categories: … Indicators and Reagents …
Matched Products: … Kit for the Preparation of Technetium Tc99m Sestamibi …

Nefopam

Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.
Approved
Investigational
Matched Description: … Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. ... Nefopam has been investigated for the prevention of Kidney Transplantation. …
Matched Products: … ACUPAN SOLUTION FOR INJECTION 20MG/2ML …

Amphotericin B

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While...
Approved
Investigational
Matched Iupac: … trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid …
Matched Description: … The antibiotic is without effect on bacteria, rickettsiae, and viruses. ... Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and ... Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. …
Matched Categories: … Antiinfectives and Antiseptics for Local Oral Treatment ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antimycotics for Systemic Use …
Matched Products: … AMPHOTRET FOR INJECTION USP 50MG ... Amphotericin B for Injection, USP ... AMBISOME FOR INJECTION 50 mg/vial …

Voriconazole

Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase...
Approved
Matched Description: … These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. ... The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [ …
Matched Categories: … Triazole and tetrazole derivatives ... Metabolic Side Effects of Drugs and Substances ... Antimycotics for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … VFEND (200 MG POWDER FOR SOLUTION FOR INFUSION ... VORICONAZOLE ALVOGEN (200 MG POWDER FOR SOLUTION FOR INFUSION) ... Voriconazole ADVAGEN powder for solution for infusion 200mg …

Fomepizole

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Approved
Vet approved
Matched Description: … alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and …
Matched Products: … Fomepizole for Injection …

Methylnaltrexone

Methylnaltrexone is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008.
Approved
Matched Categories: … Alimentary Tract and Metabolism ... Drugs for Constipation …
Matched Products: … Relistor Solution For Injection 12mg/0.6mL …

Spectinomycin

An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Approved
Investigational
Vet approved
Matched Description: … It is active against gram-negative bacteria and used for the treatment of gonorrhea. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … TROBICIN FOR INJECTION 2 g/vial …

Dactinomycin

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Synonyms: … DILACTONE ACTINOMYCIN D ACID …
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances ... Nucleic Acid Synthesis Inhibitors …
Matched Products: … DACTINOMYCIN FOR INJECTION 0.5 mg/vial …

Peginterferon alfa-2a

Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Investigational
Matched Description: … Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat ... 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment. ... development of endocrine and autoimmune disorders, retinopathies, cardiovascular and neuropsychiatric …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Treatments for Hepatitis C ... Intercellular Signaling Peptides and Proteins …
Matched Products: … PEGASYS PRE-FILLED SYRINGE FOR INJECTION 180 mcg/0.5 ml ... PEGASYS PRE-FILLED SYRINGE FOR INJECTION 135 mcg/0.5 ml …
Displaying drugs 3001 - 3025 of 3361 in total