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Displaying drugs 301 - 325 of 9163 in total

Nabumetone

Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree...
Approved
Matched Description: … [label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate ... [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone …
Matched Products: … NABUFEX 500 MG FILM TABLET, 10 ADET …

Satralizumab

Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to tocilizumab, which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune inflammatory disorder of the central...
Approved
Matched Description: … permeability of the blood-brain barrier, which allows for the passage of pro-inflammatory mediators ... This novel mechanism effectively increases the duration of action of satralizumab, as it allows for single ... autoimmune inflammatory disorder of the central nervous system (CNS) involving demyelinating lesions …

Enprofylline

Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels.
Approved
Experimental
Matched Description: … Enprofylline is a derivative of theophylline which shares bronchodilator properties. ... Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular …

Palovarotene

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … ], which are derivatives of [vitamin A]. ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million ... [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive …

Copanlisib

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. Copanlisib was granted accelerated...
Approved
Investigational
Matched Description: … A261730] Copanlisib was granted accelerated approval by the FDA in September 2017 for the treatment of …

Albendazole

A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Approved
Vet approved
Matched Products: … ALBAZOL 10% Oral Suspension ... ALBENDEX 10 % w/v Oral suspension ... ZENTEL SUSPENSION 400 mg/10 ml …

Lovastatin

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Description: … [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular ... 10 to 40mg [rosuvastatin] per day were found in clinical studies to result in a 45.8% to 54.6% decrease ... studies to significantly reduce the risk of development of CVD and all-cause mortality. …
Matched Products: … MEVACOR 10 MG …

Ketoconazole

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation...
Approved
Investigational
Matched Description: … Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal ... [FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol ... , thereby increasing membrane fluidity and preventing growth of the fungus. …
Matched Categories: … combinations of imidazole derivatives ... Metabolic Side Effects of Drugs and Substances …
Matched Products: … KONAZOL TABLET, 10 ADET ... KETORAL 200 MG TABLET, 10 ADET ... TEKNAZOL 200 MG TABLET, 10 ADET …

Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Sulfametopyrazine

Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
Approved
Withdrawn
Matched Categories: … combinations of sulfonamides …

Trichlormethiazide

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Approved
Vet approved
Matched Description: … A thiazide diuretic with properties similar to those of hydrochlorothiazide. …
Matched Categories: … combinations of sulfonamides …

Procarbazine

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Approved
Investigational
Matched Description: … combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Iothalamic acid

Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent.
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Procaine benzylpenicillin

Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It...
Approved
Vet approved
Matched Description: … It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin ... Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many ... combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of …
Matched Mixtures name: … PROKAIN PENICILLIN 3.1.400.000 IU IM ENJEKSİYONLUK TOZ, 10 ADET ... PROKAIN PENICILLIN 3.1.800.000 IU IM ENJEKSİYONLUK TOZ, 10 ADET …
Matched Categories: … combinations of penicillins …

Bictegravir

Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet.
Approved
Investigational
Matched Description: … Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Scorpion (centruroides) immune Fab2 antivenin (equine)

Centruroides (scorpion) Immune F(ab')2 (equine) is a purified preparation of immune globulin F(ab’)2 fragments that are derived from plasma of the horses immunized with venom of C. noxius, C. l. limpidus, C. l. tecomanus, and C. s. suffusus. It is intravenously administered patients with clinical signs of scorpion envenomation so...
Approved
Matched Description: … fragments that are derived from plasma of the horses immunized with venom of *C. noxius*, *C. l. limpidus ... Centruroides (scorpion) Immune F(ab')2 (equine) is a purified preparation of immune globulin F(ab’)2 ... It is intravenously administered patients with clinical signs of scorpion envenomation so that the Fab …
Matched Products: … ALVENO AC 10 ML IV ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET FLAKON+1 ADET ÇÖZÜCÜ AMPUL …

Nevirapine

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Approved
Matched Iupac: … 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10- …
Matched Description: … reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Histamine

A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Approved
Investigational
Matched Description: … It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator ... A depressor amine derived by enzymatic decarboxylation of histidine. …
Matched Products: … อัลเลอร์แว็กซ์เทสต์ น้ำยาควบคุมผลบวก 10 ... Prick Test Histamin LETI Positivkontrolle 10 mg/ml Pricktestlösung ... HAL Allergy Pricktest 10 mg/ml Pricktestlösung zur Positivkontrolle …

Benzoic acid

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads...
Approved
Investigational
Matched Description: … This leads to excretion of these amino acids and a decrease in ammonia levels. ... Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo. …

Gemeprost

Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in...
Approved
Withdrawn
Matched Iupac: … methyl (2E)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4,4-dimethyloct-1-en-1-yl]-5-oxocyclopentyl] …
Matched Description: … Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the ... suppositories and also used in combination with the antiprogestin and mifepristone for termination of …

Octreotide

Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … hormone, somatostatin, which inhibits the secretion of growth hormone. ... Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues ... [L14501] Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural …
Matched Products: … SANDOSTATIN LAR 10 MG ... SANDOSTATIN LAR FOR INJECTION 10 mg ... SANDOSTATIN LAR 10 MG ENJEKSİYONLUK SÜSPANSİYON İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET …

Brigatinib

Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a...
Approved
Investigational
Matched Description: … It presents selectivity against the mutant forms of EGFR compared to the wild-type. ... Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK ... fusion gene, which is a pivotal player in the transformation of susceptible lung parenchyma. …
Matched Mixtures name: … ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 21 ADET 180 MG ... ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 21 ADET 180 MG …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures ... interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of …
Matched Products: … ICEREN, 10 FLAKON ... LEVETIRACETAM 100MG+10 HOR ... LEVETIRACETAM 100MG+10 NET …

Deferoxamine

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Approved
Investigational
Matched Products: … DESFERAL 500 MG IM/IV/SC ENJEKSİYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 10 ADET …

Colchicine

Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events....
Approved
Matched Iupac: … N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl …
Matched Description: … prevention of major cardiovascular events. ... [L8192] Colchicine is used in the treatment of gout flares and Familial Mediterranean fever,[L8138] and …
Displaying drugs 301 - 325 of 9163 in total