Displaying drugs 301 - 325 of 8197 in total
Saxagliptin
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Approved
Matched Description: … -4 (DPP-4) inhibitor class of drugs. ... Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase …
Maralixibat
Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like odevixibat.[A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome. Previously, patients with cholestatic pruritus associated with Alagille syndrome were treated with antihistamines, rifampin, ursodeoxycholic acid, cholestyramine, naltrexone, and...
Approved
Investigational
Matched Description: … [A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients ... [A239249] No clinical trials have been performed to assess the efficacy of these treatments for cholestatic ... Products for Human Use (CHMP) recommended maralixibat be granted marketing authorization for the treatment of …
Ceftriaxone
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges , eyes , and inner ear . Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone...
Approved
Matched Description: … its relatively safe adverse effect profile, and its long half-life which allows for the convenience of …
Bexagliflozin
Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.[A256408,A256413,L44758] Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such as SGLT1, SGLT2 is...
Approved
Investigational
Matched Description: … urinary glucose excretion, which reduces blood glucose levels independently of insulin sensitivity. ... [A256413] SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such ... [A256408] By inhibiting SGLT2, bexagliflozin reduces renal reabsorption of filtered glucose and increases …
Etelcalcetide
Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Approved
Investigational
Matched Description: … Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism ( ... Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing …
Beta carotene
Beta-carotene, with the molecular formula C40H56, belongs to the group of carotenoids consisting of isoprene units. The presence of long chains of conjugated double bonds donates beta-carotene with specific colors. It is the most abundant form of carotenoid and it is a precursor of the vitamin A. Beta-carotene is composed...
Approved
Nutraceutical
Matched Description: … [T162] It is the most abundant form of carotenoid and it is a precursor of the vitamin A. ... The presence of long chains of conjugated double bonds donates beta-carotene with specific colors. ... Beta-carotene, with the molecular formula C40H56, belongs to the group of carotenoids consisting of isoprene …
Bevacizumab
There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … with severe cases of COVID-19. ... for the survival and proliferation of cancer cells. ... There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important …
Treprostinil
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment...
Approved
Investigational
Matched Description: … Treprostinil is a stable tricyclic analogue of prostacyclin[A248770] that promotes the vasodilation of ... that significantly increases patients' quality of life. ... The first generic form of treprostinil became available in 2019.[A248775] …
Cimetidine
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … Cimetidine has a range of pharmacological actions. ... It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Aminocaproic acid
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
Approved
Investigational
Fenoprofen
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Approved
Cenobamate
Cenobamate, or YKP-3089, is an antiepileptic drug developed by SK Pharmaceuticals and used to treat partial onset seizures.[A188442,L10653] The exact mechanism of action has not been described in the literature, though it positively modulates GABAA and inhibits voltage gated sodium channels. Cenobamate was granted FDA approval on 21 November 2019.
Approved
Investigational
Matched Description: … [A188442,L10653] The exact mechanism of action has not been described in the literature, though it positively …
Tavaborole
Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis...
Approved
Investigational
Matched Description: … ATP-dependent ligation of L-leucine to tRNA(Leu). ... Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, ... a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes …
Bacitracin
Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A181997,L7748]
Approved
Vet approved
Matched Description: … Bacitracin is a combination of at least 9 bacitracins. ... [A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. ... bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of …
Aclidinium
Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Approved
Matched Description: … Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease …
Mifamurtide
Mifamurtide is an immunomodulator with antitumor activity via activation of macrophages and monocytes. Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP). MDP is a motif present in all gram-positive and...
Approved
Experimental
Matched Description: … Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is ... The overall result of MDP recognition leads to the production of proinflammatory cytokines and promotion ... of bactericidal and tumoricidal effects [A31745]. …
Febuxostat
Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Description: … [L32238] Gout is a form of arthritis that is caused by the accumulation of uric acid crystal in or around ... Febuxostat works by inhibiting the activity of an enzyme that is responsible for the synthesis of uric ... [A230548] In the following year, the FDA for approved febuxostat for use in the chronic management of …
Fluconazole
Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole...
Approved
Investigational
Matched Description: … The side effect profile of this drug is minimal. ... and superficial fungal infections in a variety of tissues. ... Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic …
Indacaterol
Indacaterol is a novel, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011. It is marketed in Europe as...
Approved
Matched Description: … ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of …
Palovarotene
Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … ], which are derivatives of [vitamin A]. ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million ... [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive …
Valproic acid
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into...
Approved
Investigational
Matched Description: … is the subject of many clinical trials in a variety of cancer types. ... of anticonvulsive activity. ... It is currently a compound of interest in the field of oncology for its anti-proliferative effects and …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Pepsin
Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products .
Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated...
Approved
Experimental
Investigational
Matched Description: … Stimulation of the pancreas and therefore enzymatic digestion of food is a tightly controlled and is ... Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in ... the presence of stomach acid, causes nutrients including meat or coagulated egg whites to dissolve. …
Peanut oil
Peanut oil is derived from Arachis hypogaea which can be found in South America, Mexico, and Centro America. The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. The peanut oil represents about 45-52% of the kernel content and it is mainly formed...
Approved
Matched Description: … The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. ... The peanut oil represents about 45-52% of the kernel content and it is mainly formed from monounsaturated …
Avacincaptad pegol
Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule. It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA). AMD is the leading cause of vision loss in developed countries for people over 50 years old, with...
Approved
Investigational
Matched Description: … with a global estimate of 170 million individuals affected. ... the non-neovascular (dry) or the neovascular (wet) form of AMD. ... It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic …
Verapamil
Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … [A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, ... , each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater …
Displaying drugs 301 - 325 of 8197 in total