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Displaying drugs 326 - 350 of 774 in total

Cultivated mushroom

Cultivated mushroom allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Agaricus bisporus (mushroom) cap/stem extract …

Glycerin

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Approved
Investigational
Matched Mixtures name: … Advanced DNA Medicated Collection ... Professional Medicated DNA Collection ... Advanced DNA Medicated Collection Kit II …
Matched Products: … Medi Stem Eye ... Medi Stem Collagen ... Medi Stem Collagen Toner …

Darvadstrocel

Darvadstrocel is a suspension of expanded human allogeneic adipose-derived mesenchymal stem cells extracted from the subdermal adipose tissue of healthy donors via liposuction. Darvadstrocel was first approved by the European Commission on March 23, 2018, under the brand name Alofisel. It is indicated for the treatment of complex perianal fistulas...
Approved
Experimental
Matched Description: … Darvadstrocel is a suspension of expanded human allogeneic adipose-derived mesenchymal stem cells extracted ... [L39759] It is the first mesenchymal stem cell therapy approved in Europe for this therapeutic indication …
Matched Categories: … Stem Cells …

Decitabine

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.[A215082, A215092] Among treatment options, nucleoside analogues such as...
Approved
Investigational
Matched Description: … treatment options, nucleoside analogues such as decitabine and [azacitidine] integrate into cellular DNA ... and inhibit the action of DNA methyltransferases, leading to global hypomethylation and related downstream …

Plerixafor

Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.[A7117,L45678] It is used to stimulate the release of stem cells from the bone marrow into the blood in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma to stimulate their immune...
Approved
Investigational
Matched Description: … These stem cells are then collected and used in autologous stem cell transplantation to replace blood-forming ... a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem ... [A7117,L45678] It is used to stimulate the release of stem cells from the bone marrow into the blood …
Matched Categories: … Hematopoietic Stem Cell Mobilizer ... Increased Hematopoietic Stem Cell Mobilization …

Nicotinamide

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Approved
Investigational
Matched Mixtures name: … Medi Hydro DP Stem C Ampoule ... Stem Cell Hmsc Cell Rejuvenation-ampoule ... Jayjun Collagen Skin Fit Mask Step 02 Plant Stem Cell Mask …
Matched Products: … Stem Cell Whitening Serum ... NYAAM NYAAM Mulberry Stem Serum …

Valaciclovir

Valaciclovir (valacyclovir), also known as Valtrex, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline . Valacyclovir is the L-valine ester of aciclovir. It...
Approved
Investigational
Matched Categories: … Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor ... Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor ... Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor …

Glasdegib

Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionality. The great lipophilicity of this group of compounds...
Approved
Investigational

Etoposide

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division,...
Approved
Matched Description: … Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. ... This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. ... Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death …

Teniposide

Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic...
Approved
Matched Description: … Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. ... This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. ... Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead …

Gemtuzumab ozogamicin

Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody [FDA Label]. The antibody is specifically...
Approved
Investigational

Elivaldogene autotemcel

Elivaldogene autotemcel is a gene therapy consisting of genetically modified autologous cells. It is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy, an X-linked genetic disorder characterized by missing or non-functional ABCD1 gene that codes for ALDP. ALDP is a key protein that normally...
Approved
Matched Description: … Allogeneic hematopoietic stem-cell transplantation has been the primary treatment option; however, it ... Gene therapy with autologous hematopoietic stem cells was introduced and investigated as a possible treatment …

Prochlorperazine

Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking...
Approved
Vet approved

Thiotepa

N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow...
Approved
Investigational

Topotecan

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Approved
Investigational
Matched Description: … It works by inhibiting DNA topoisomerases, type I. …

Prazepam

Prazepam is a benzodiazepine that is used in the treatment of anxiety disorders. It is a schedule IV drug in the U.S.
Approved
Illicit

Cytarabine

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale,...
Approved
Investigational
Matched Description: … Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. …

Fludarabine

Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Approved
Matched Categories: … DNA (Cytosine-5-)-Methyltransferases, antagonists & inhibitors …

Lamivudine

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Approved
Investigational

Gemifloxacin

Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase …

Delavirdine

A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.
Approved

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Approved
Investigational

Idoxuridine

An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent.
Approved
Investigational
Matched Description: … An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent. …

Inotersen

Inotersen is a transthyretin-directed antisense oligonucleotide for the treatment of the polyneuropathy caused by hereditary transthyretin-mediated amyloidosis in adults. It was FDA approved in October 2018. Inotersen has been shown to improve the course of neurologic disease and quality of life in patients with hereditary transthyretin amyloidosis . Hereditary transthyretin...
Approved
Investigational
Matched Categories: … DNA, Antisense …

Cyclophosphamide

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects,...
Approved
Investigational
Displaying drugs 326 - 350 of 774 in total