Displaying drugs 351 - 375 of 8033 in total
Alprostadil
Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used in men for whom oral treatment...
Approved
Investigational
Matched Description: … Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator ... After administration, alprostadil promotes smooth muscle relaxation of the corpus cavernosal. ... In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection …
Ferrous sulfate anhydrous
Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is...
Approved
Matched Description: … the formation of erythrocytes, also known as red blood cells. ... anemia is a large public health concern worldwide, especially in young children, infants, and women of ... [A190528]
Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. …
Acemetacin
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin. It was developed by...
Approved
Investigational
Matched Description: … Acemetacin is a carboxymethyl ester of indometacin. ... acetamicin led to the formation of indomethacin and it kept the same side effects. ... provide a safer drug but other than the amelioration on the gastrointestinal effects, the metabolism of …
Tranexamic acid
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Approved
Matched Description: … prevention of major bleeding. ... Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and ... It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent …
Anidulafungin
Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin.
Approved
Investigational
Clonidine
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246]
Clonidine was granted FDA approval on 3 September 1974.
Approved
Matched Description: … Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. ... [A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD. …
Ceritinib
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Description: … of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. ... Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic ... non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior …
Molindone
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate...
Approved
Matched Description: … the aggressive type of undersocialized conduct disorder. ... indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of ... electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of …
Amlodipine
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched Description: … The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label]. ... Amlodipine is commonly used in the treatment of high blood pressure and angina. ... Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of …
Rimexolone
Rimexolone is a 1% eye drop solution is a glucocorticoid steroid. It is used to treat inflammation in the eye. It is marketed as Vexol.
Approved
Ponatinib
Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Approved
Investigational
Matched Description: … tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of …
Siponimod
Siponimod, also known as Mayzent, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a sphingosine-1-phosphate (S1P) receptor modulator and is thought to...
Approved
Investigational
Matched Description: … [L5801] MS is one of the most common causes of neurological disability in young adults and is found to ... 20 to 40, often the most productive years of life. ... , disrupting communication between the brain and other parts of the body. …
Polymyxin B
Polymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci,...
Approved
Vet approved
Matched Description: … It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused ... by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. ... They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes …
Netilmicin
Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect...
Approved
Investigational
Matched Description: … The bactericidal effect of netilmiicin is not fully understood. ... Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action …
Ganciclovir
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Approved
Investigational
Matched Description: … An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. …
Nirmatrelvir
Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of clinical trial NCT04756531. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication.[A234224,A234229,A234234]...
Approved
Investigational
Matched Description: … of being orally bioavailable. ... [L33354] 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. ... 07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of …
Bosutinib
Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Description: … [A6901,A17961]
Bosutinib was first approved by the FDA in 2012 for the treatment of adult chronic, ... [L48436] On September 26, 2023, bosutinib was also approved by the FDA for the treatment of pediatric ... Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting …
Ammonia
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a...
Approved
Matched Description: … Ammonia is a natural byproduct of biological and chemical reactions, including decomposition of organic ... It is proposed that human adults produce about 1000 mmol of ammonia daily, most of which undergoes excretion ... Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal …
Ipratropium
Ipratropium is a quaternary ammonium derivative of atropine that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its first monotherapy product was FDA approved...
Approved
Experimental
Matched Description: … Ipratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic ... Ingelheim and its first monotherapy product was FDA approved in 1986, while the combination product of …
Ammonia N-13
Ammonia N 13 Injection, USP is a positron emitting radiopharmaceutical that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging. The active ingredient, [13N] ammonia, has the molecular formula of 13NH3 with a molecular weight of 16.02.
Ammonia N 13 Injection, USP is used for imaging...
Approved
Matched Description: … The active ingredient, [13N] ammonia, has the molecular formula of 13NH3 with a molecular weight of 16.02 ... Ammonia N 13 Injection, USP is used for imaging of the myocardium under rest or pharmacologic stress …
Bremelanotide
Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it...
Approved
Investigational
Racepinephrine
Racepinephrine is a racemic mixture consisting of d-DB00668 and l-DB00668 enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingredient in...
Approved
Matched Description: … wheezing, tightness of chest and shortness of breath. ... It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including ... Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. …
Amisulpride
Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major depression. Amisulpride predominantly works in...
Approved
Investigational
Matched Description: … As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia ... [A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and ... A6755] Amisulpride predominantly works in the limbic system, which explains its relatively lower risk of …
Lornoxicam
Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
Approved
Investigational
Matched Description: … , a property that explains the particularly pronounced efficacy of the drug. ... Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class ... Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis …
Methotrexate
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Description: … [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division ... are intolerant of those treatments. ... of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients …
Displaying drugs 351 - 375 of 8033 in total