Displaying drugs 401 - 425 of 12390 in total
Tirzepatide
Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … [A246260]
Tirzepatide comprises a 39 amino acid linear synthetic peptide conjugated to a C20 fatty ... on GLP-1 receptors is comparable to endogenous GIP; however, the long half-life of tirzepatide allows ... was approved by the FDA on May 13, 2022, under the brand name MOUNJARO by the FDA for the treatment of …
Trovafloxacin
Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective...
Approved
Investigational
Withdrawn
Matched Description: … Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan ... by blocking the activity of DNA gyrase and topoisomerase IV. ... It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria …
Fenofibric acid
Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L12855] Due to its high hydrophilicity and poor absorption profile, prodrug ,fenofibrate, and other conjugated compounds...
Approved
Matched Description: … Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia ... hydrophilicity and poor absorption profile,[A32038] prodrug ,[fenofibrate], and other conjugated compounds of …
Ergocalciferol
Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolated for the...
Approved
Nutraceutical
Matched Description: … a double bond between C22 and C23 and the presence of a methyl group at C24. ... [T577] The production of ergocalciferol was prompted by the identification of dietary deficiency, more ... [A177526] It is synthesized by some plants in the presence of UVB light. …
Matched Mixtures name: … One A Day Tab ... Aquasol A & D Drops ... Complete One A Day Tab …
Matched Mixtures name: … One A Day Tab ... Aquasol A & D Drops ... Complete One A Day Tab …
Triclocarban
Triclocarban, with the chemical formula C13H9Cl3N2O is an antibacterial agent that is particularly effective against Gram-positive bacteria such as Staphylococcus aureus. It is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products. In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer...
Approved
Matched Description: … In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer antiseptic wash products ... It is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products …
Polidocanol
Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural...
Approved
Matched Description: … (n) of approximately 9 and a mean molecular weight of approximately 600. ... The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization ... Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Idarucizumab
Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when...
Approved
Matched Description: … As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran ... Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype ... Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of …
Propofol
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness,...
Approved
Investigational
Vet approved
Matched Description: … using a combination of medications. ... Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia ... IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained …
Zopiclone
Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.
Approved
Matched Description: … Zopiclone is a novel hypnotic agent used in the treatment of insomnia. ... Its mechanism of action is based on modulating benzodiazepine receptors. …
Permethrin
A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Approved
Investigational
Matched Description: … A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. ... It is a yellow to light orange-brown, low melt-ing solid or viscous liquid. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … A Scabs ... A-LICES LOTION 1%w/w …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … A Scabs ... A-LICES LOTION 1%w/w …
Thalidomide
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha...
Approved
Investigational
Withdrawn
Matched Description: … It has been reintroduced and used for a number of inflammatory disorders and cancers. ... A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn ... Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of …
Levetiracetam
Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures ... desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic ... indexes and a propensity for involvement in drug interactions. …
Methadone
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a...
Approved
Matched Description: … , and a long duration of action. ... ; in particular, methadone has a lower risk of neuropsychiatric toxicity compared to other opioids (due ... It also has a number of unique characteristics that have led to its increased use in the last two decades …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Bevacizumab
There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important ... neutralizing VEGF-A. ... with severe cases of COVID-19. …
Treprostinil
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment...
Approved
Investigational
Matched Description: … Treprostinil is a stable tricyclic analogue of prostacyclin[A248770] that promotes the vasodilation of ... [L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin ... that significantly increases patients' quality of life. …
Cimetidine
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … Cimetidine has a range of pharmacological actions. ... A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. ... It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Bexagliflozin
Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.[A256408,A256413,L44758] Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such as SGLT1, SGLT2 is...
Approved
Investigational
Matched Description: … Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. ... other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a ... urinary glucose excretion, which reduces blood glucose levels independently of insulin sensitivity. …
Etelcalcetide
Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Approved
Investigational
Matched Description: … Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing ... Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism ( …
Maralixibat
Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like odevixibat.[A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome. Previously, patients with cholestatic pruritus associated with Alagille syndrome were treated with antihistamines, rifampin, ursodeoxycholic acid, cholestyramine, naltrexone, and...
Approved
Investigational
Matched Description: … pruritus and treatments were given based on a prescriber's clinical experience. ... [A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients ... [A239249] No clinical trials have been performed to assess the efficacy of these treatments for cholestatic …
Saxagliptin
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Approved
Matched Description: … -4 (DPP-4) inhibitor class of drugs. ... Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase …
Beta carotene
Beta-carotene, with the molecular formula C40H56, belongs to the group of carotenoids consisting of isoprene units. The presence of long chains of conjugated double bonds donates beta-carotene with specific colors. It is the most abundant form of carotenoid and it is a precursor of the vitamin A. Beta-carotene is composed...
Approved
Nutraceutical
Matched Description: … [T162] It is the most abundant form of carotenoid and it is a precursor of the vitamin A. ... [T158] Under the FDA, beta-carotene is considered as a generally recognized as safe substance (GRAS). ... The presence of long chains of conjugated double bonds donates beta-carotene with specific colors. …
Matched Mixtures name: … Aces Formula/formule A A S ... A/o-26 - Caplet ... Extra Once A Day …
Matched Categories: … Vitamin A …
Matched Products: … Beta A 10000 Cap ... BETA-CAROTENE 15 MGPROVITAMIN A 25.000 IU …
Matched Mixtures name: … Aces Formula/formule A A S ... A/o-26 - Caplet ... Extra Once A Day …
Matched Categories: … Vitamin A …
Matched Products: … Beta A 10000 Cap ... BETA-CAROTENE 15 MGPROVITAMIN A 25.000 IU …
Regadenoson
Regadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial perfusion imagining. Manufactured by Astellas and FDA approved April 10, 2008.
Approved
Investigational
Matched Categories: … Adenosine A receptor agonists …
Rabies virus inactivated antigen, A
Rabies virus inactivated antigen, A is an inactivated virus vacine for the intramuscular injection. It is an active immunization against rabies that can be administered pre- or post-exposure to the rabies virus.
Approved
Investigational
Matched Name: … Rabies virus inactivated antigen, A …
Matched Description: … Rabies virus inactivated antigen, A is an inactivated virus vacine for the intramuscular injection. …
Matched Description: … Rabies virus inactivated antigen, A is an inactivated virus vacine for the intramuscular injection. …
Clemastine
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Approved
Investigational
Febuxostat
Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Description: … [L32238] Gout is a form of arthritis that is caused by the accumulation of uric acid crystal in or around ... a post-market clinical study (the CARES trial) where there was an increased risk of cardiovascular ( ... [A230548]
In February 2019, a black box warning for febuxostat was added, based on the findings of …
Displaying drugs 401 - 425 of 12390 in total