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Displaying drugs 401 - 425 of 5061 in total

Influenza B virus B/Hubei-Wujiagang/158/2009 BX-39 antigen (UV, formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... A seasonally-specific component of the influenza vaccine. …

Demeclocycline

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Synonyms: … 12aα)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2- …
Matched Iupac: … chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2- …
Matched Description: … A tetracycline analog having a 7-chloro and a 6-methyl. …
Matched Salts cas: … 64-73-3 …

Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … [A261281,A261286] Due to the 2 fused VEGFR, aflibercept has a higher affinity to the cognate ligands ... it was approved by the FDA and EMA in August 2012 and February 2013, respectively. ... [A261130] Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … ZALTRAP 100MG/4ML INFUZYONLUK KONSANTRE COZELTI İÇEREN FLAKON, 3 ADET …

Triflupromazine

A phenothiazine used as an antipsychotic agent and as an antiemetic.
Approved
Vet approved
Matched Synonyms: … 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine ... 2-(Trifluoromethyl)promazine ... 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine …
Matched Iupac: … dimethyl({3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl})amine …
Matched Description: … A phenothiazine used as an antipsychotic agent and as an antiemetic. …
Matched Categories: … Heterocyclic Compounds, 3-Ring …

Dostarlimab

Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the anti-tumor immune response that would typically attempt...
Approved
Investigational
Matched Description: … [L33340] A companion diagnostic device - the VENTANA MMR RxDx Panel - was also approved alongside this ... immune-mediated anti-tumor activity and may therefore be used to treat a wide variety of cancers, including ... those of the skin, lung, kidneys, and liver. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Avelumab

Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year,...
Approved
Investigational
Matched Description: … [A261496] Avelumab was first approved by the FDA on March 23, 2017. ... Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) ... ] and Health Canada,[L48171] respectively. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Susoctocog alfa

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Description: … In a global, prospective, controlled, multi-center Phase 2/3 open-label clinical trial, all patients ... Susoctocog alfa was approved by the FDA in October 2014 and is marketed under the brand name Obizur for ... Susoctocog alfa is a glycoprotein containing a 90 kDa heavy chain and a 80 kDa light chain with the naturally-occuring …
Matched Categories: … Blood and Blood Forming Organs …

Flutamide

An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Approved
Investigational
Matched Synonyms: … 4'-nitro-3'-trifluoromethylisobutyranilide ... α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide …
Matched Iupac: … 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide …
Matched Description: … An antiandrogen with about the same potency as cyproterone in rodent and canine species. …
Matched Categories: … Hormone Antagonists and Related Agents ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

LetibotulinumtoxinA

The aesthetic utility of botulinum toxin was discovered incidentally following its initial use in the treatment of facial spasmodic disorders in the early 1970s. The first aesthetic use of botulinum toxin was reported in 1989, when onabotulinumtoxinA (Botox) was used as a treatment for facial asymmetry resulting from iatrogenic facial...
Approved
Matched Synonyms: … BoNT/A-DS …
Matched Description: … years and was subsequently approved in the European Union. ... [A249920] It was subsequently approved by the FDA in 1992 for use in aesthetic procedures and has since ... ] and in the US in March 2024. …
Matched Categories: … Botulinum Toxins, Type A …

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Synonyms: … 1-Butyl-3-tosylurea ... 1-Butyl-3-(p-tolylsulfonyl)urea ... 1-p-Toluenesulfonyl-3-butylurea …
Matched Iupac: … 3-butyl-1-(4-methylbenzenesulfonyl)urea …
Matched Description: … Tolbutamide and its metabolites are excreted in urine (75-85%) and feces. ... It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea ... increase the number and sensitivity of insulin receptors. …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Collagenase clostridium histolyticum

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers. On July 6,...
Approved
Investigational
Matched Synonyms: … Clostridiopeptidase A …
Matched Description: … [L14912] On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA ... [L14872] Also known as Qwo, this injection is the first approved injectable treatment for cellulite and ... was developed by Endo International. …
Matched Categories: … Enzymes and Coenzymes ... Skin and Mucous Membrane Agents ... Preparations for Treatment of Wounds and Ulcers …

Daridorexant

Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. It chronically affects the person's daily functioning and long-term health effects, as insomnia is often associated with comorbidities...
Approved
Matched Iupac: … 5-chloro-2-[(2S)-1-[5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoyl]-2-methylpyrrolidin-2-yl]-4-methyl-1H- …
Matched Description: … [A244280] Daridorexant was approved by the European Commission on May 3, 2022, as the first dual orexin ... receptor antagonist approved in the market,[L41725] and by Health Canada on April 26, 2023. ... Conventional treatments for insomnia include drugs targeting gamma-aminobutyric acid type-A (GABA-A), …
Matched Categories: … Hypnotics and Sedatives …

Atezolizumab

Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing ... voluntarily withdrew the use of atezolizumab for the treatment of urothelial carcinoma, previously approved …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Octreotide

Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … On June 26, 2020, the first approved delayed-release oral somatostatin analog, Mycapssa, received FDA ... Acromegaly is a life-threatening disease requiring life-long management. ... and causing metabolic dysfunction. …
Matched Salts cas: … 135467-16-2 …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues …

Phenoxyethanol

Phenoxyethanol is a colorless liquid with a pleasant odor. It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. Phenoxyethanol is an ether alcohol with aromatic properties. It is both naturally found and manufactured synthetically. Demonstrating antimicrobial...
Approved
Matched Synonyms: … 2-phenoxyethanol ... 1-Hydroxy-2-phenoxyethane ... 2-Phenoxyethyl alcohol …
Matched Iupac: … 2-phenoxyethan-1-ol …
Matched Description: … Phenoxyethanol (EU), or PE, is the most commonly used globally-approved preservative in personal care ... a low water solubility and evaporation rate. ... Phenoxyethanol is a colorless, clear, oily liquid with a faint aromatic odor at room temperature and …

Azithromycin

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Iupac: … (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl ... ]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14 …
Matched Description: … It was initially approved by the FDA in 1991 [A174175]. ... Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue ... , and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at …
Matched Categories: … cefixime and azithromycin ... azithromycin, fluconazole and secnidazole ... Macrolides, Lincosamides and Streptogramins …
Matched Products: … ZITROTEK FILM KAPLI TABLET, 2 ADET ... AZİTROTEK 500 MG FİLM TABLET, 2 TABLET ... ZITROMAX SD 2 G/60 ML ORAL SÜSPANSIYON IÇIN UZATILMIŞ SALIMLI GRANÜL …

Anthrax vaccine

Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to Bacillus anthracis. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis...
Approved
Matched Description: … [L47561] There are currently 2 anthrax vaccines approved by the FDA: BioThrax in August 15, 2016 and ... [L47526] It is considered one of the most likely agents to be used in a biological attack. ... Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high …

Lorazepam

Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.
Approved
Matched Iupac: … 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Description: … Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic ... [A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …
Matched Products: … LORANS 2 TABLET ... ATIVAN 2 MG TABLETAS ... LORAZEPAM 2 MG TABLETAS …

Defibrotide

Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of...
Approved
Investigational
Matched Description: … It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries. ... In the USA it is was approved in March, 2016 as Defitelio. ... Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …

Kappadione

Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Iupac: … tetrasodium 3-methyl-4-(phosphonatooxy)naphthalen-1-yl phosphate …
Matched Description: … Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved ... by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not ... Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study …

Ixabepilone

Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is...
Approved
Investigational
Matched Iupac: … (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4- ... yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione …
Matched Description: … Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally ... Ixabepilone is a semisynthetic analogue of epothilone B. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Recombinant stabilized RSV B prefusion F antigen

Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial virus (RSV) vaccine called Abrysvo. The vaccine comprises two antigens - the other being recombinant stabilized RSV A prefusion F antigen - which have been expressed in Chinese hamster ovary cell lines and then purified...
Approved
Matched Description: … [L49555] Abrysvo was approved for the same indications in the EU in August 2023[L49565] and Canada in ... [L48066] Abrysvo was first approved by the FDA in May 2023 for use in patients ≥60 years of age, and ... Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial …

Liotrix

Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion....
Approved
Matched Iupac: … disodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate (2S)-2-amino-3-[ ... 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate …
Matched Description: … a 4 to 1 ratio by weight. ... Liotrix is a synthetically derived thyroid hormone replacement preparation. ... and combination hormone replacement therapy generally offers no therapeutic advantage. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Synonyms: … 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione …
Matched Iupac: … 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione …
Matched Description: … Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. ... Buspirone was first approved in 1986 by the FDA [A181751] and has been used to treat anxiety disorders ... Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT1A …
Matched Salts cas: … 33386-08-2 …
Matched Categories: … Miscellaneous Anxiolytics Sedatives and Hypnotics …

Peanut oil

Peanut oil is derived from Arachis hypogaea which can be found in South America, Mexico, and Centro America. The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. The peanut oil represents about 45-52% of the kernel content and it is mainly formed...
Approved
Matched Description: … The kernels are consumed roasted but a large percentage is used for the production of vegetable oil. ... Peanut oil is derived from _Arachis hypogaea_ which can be found in South America, Mexico, and Centro ... [A33169] Under the FDA, peanut oil is categorized as an approved inactive ingredient for its use in …
Matched Categories: … Basic Ointments and Protectants …
Matched Products: … Oilatum Soap - 2% …
Displaying drugs 401 - 425 of 5061 in total