Displaying drugs 426 - 450 of 8197 in total
Strontium chloride
Strontium chloride (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession [A33167, A33168]. This kind of barrier protection for tooth hypersensitivity has, however, been...
Approved
Matched Description: … Strontium chloride (SrCl2) is a salt of strontium and chloride. ... chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of ... This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste …
Cefoxitin
Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
Approved
Human vaccinia virus immune globulin
Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody [FDA Label, A33814]. The IgG fraction is purified by the anion-exchange column chromatography...
Approved
Matched Description: … from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of ... vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of ... Nevertheless, VIG by virtue of the way it is produced is a poorly characterized and highly variable human …
Cisatracurium
Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate.[A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.[A253592,A253597]. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is...
Approved
Investigational
Matched Description: … [A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly ... [A243416] Compared to atracurium, cisatracurium produces a lower degree of histamine release. ... Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available …
Calcitriol
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to DB00169 (vitamin D3)...
Approved
Nutraceutical
Matched Description: … It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to ... Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred ... Calcitriol is considered to be the most potent metabolite of vitamin D in humans [A3366]. …
Alfuzosin
Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases...
Approved
Investigational
Matched Description: … 80%-90% of those over 70. ... Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads ... The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to …
Ceftobiprole
Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially as the prodrug ceftobiprole medocaril. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA).
The EMA's Committee for Medicinal Products for Human Use (CHMP)...
Approved
Investigational
Matched Description: … medocaril in February 2010, recommending the refusal of its marketing authorization in the European ... activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of ... The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole …
Fidaxomicin
Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by Clostridioides (formerly Clostridium) difficile in adult and pediatric patients over the age of 6 months. Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation. Because fidaxomicin contains an 18-membered lactone ring in its structure, it is...
Approved
Matched Description: … of fidaxomicin. ... diarrhea in adult patients over the age of 18. ... patients over the age of 6 months in the treatment population. …
Artesunate
Artesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin. Artesunate was granted FDA approval on 26 May 2020.
Approved
Investigational
Matched Description: … [L890] Artesunate was developed out of a need for a more hydrophilic derivative of [artemisinin]. ... Artesunate is indicated for the initial treatment of severe malaria. …
Viltolarsen
Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Matched Description: … restore partial muscle function and slow the progression of DMD. ... Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of ... is characterized by the production of shortened and partially functional dystrophin protein. …
Pregabalin
Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evidence that pregabalin exerts its effects...
Approved
Investigational
Matched Description: … [A187190] Although as per the FDA Label the mechanism of action has not been definitively characterized ... , there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent …
Flutamide
An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Approved
Investigational
Relugolix
Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under the brand name...
Approved
Investigational
Matched Description: … treatment of prostate cancer. ... [L42150] Relugolix has also been studied in the symptomatic treatment of endometriosis. ... Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several …
Troglitazone
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Description: … Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. …
Meprobamate
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated)....
Approved
Illicit
Matched Description: … It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia ... with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of …
Salmeterol
Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, salbutamol. Salmeterol was first described in the literature in 1988. Salmeterol's structure...
Approved
Matched Description: … long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of ... [L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 …
Cyproheptadine
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Approved
Matched Description: … Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. ... perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of …
Trofinetide
Trofinetide is a novel synthetic analog of glypromate, also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1). Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[L45718,L45748] which is an X-linked...
Approved
Investigational
Matched Description: … Trofinetide is a novel synthetic analog of [glypromate], also known as glycine–proline–glutamate (GPE ... [A258438] Trofinetide is believed to work by reducing inflammation and apoptosis of neurons. ... [A258438] Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[ …
Butylscopolamine
Butylscopolamine is a peripherally acting antimuscarinic, anticholinergic agent. It is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not a pain medication in the normal sense, since it...
Approved
Investigational
Vet approved
Matched Description: … It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic …
Lumiracoxib
Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling...
Approved
Investigational
Matched Description: … On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the ... FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver …
Olopatadine
Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions. It is a structural analog of doxepin, which has a minimal anti-allergic activity. Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator that causes inflammatory and...
Approved
Matched Description: … An ophthalmic solution of olopatadine was approved by the FDA and European Union for the treatment of ... It is a structural analog of [doxepin], which has a minimal anti-allergic activity. ... [L6790] Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator …
Bimatoprost
Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has the ability to reduce ocular hypotension, proving effective in conditions such as...
Approved
Investigational
Matched Description: … are synthetic structural analogs of prostaglandin. ... Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which …
Linagliptin
Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding . Linagliptin was approved by...
Approved
Matched Description: … Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes …
Mirvetuximab soravtansine
Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody (M9346A) that targets folate receptor alpha (FRα), covalently joined by a cleavable disulfide linker to the genotoxic compound DM4 (also known as soravtansine or ravtansine).[A254392,L43967] DM4 is conjugated to the antibody with a drug-to-antibody ratio of 3.5:1....
Approved
Investigational
Matched Description: … on the surface of epithelial tumor cells, characteristic of ovarian, endometrial, triple-negative breast ... [A254392,L43967] DM4 is conjugated to the antibody with a drug-to-antibody ratio of 3.5:1. ... [A254387]
The antibody component of mirvetuximab soravtansine-gynx binds to FRα, a receptor overexpressed …
Estradiol acetate
Estradiol acetate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. ... Ester pro-drugs of estradiol are therefore considered to be bioidentical forms of estrogen [T84]. ... Administration of synthetic and bioidentical forms of estrogen, such as estradiol acetate, has shown …
Displaying drugs 426 - 450 of 8197 in total