Displaying drugs 4526 - 4550 of 8282 in total
Resiniferatoxin
Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Investigational
Matched Description: … primary afferent sensory neurons involved in nociception (the transmission of physiological pain). ... naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of …
Brimapitide
Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers).
Investigational
Matched Description: … iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers). ... Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single …
Afabicin
Afabicin is under investigation in clinical trial NCT03723551 (Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus).
Investigational
Matched Description: … Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus). ... under investigation in clinical trial NCT03723551 (Study to Assess Safety, Tolerability and Efficacy of …
ORP-101
ORP-101 is under investigation in clinical trial NCT04129619 (A Comparison of the Effects of ORP-101 Versus Placebo in Adult Patients With Irritable Bowel Syndrome With Diarrhea (IBS-D)).
Investigational
Matched Description: … ORP-101 is under investigation in clinical trial NCT04129619 (A Comparison of the Effects of ORP-101 …
IPI-549
IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma).
Investigational
Matched Description: … IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 …
SRP 299
SRP 299 is a preparation of killed Mycobacterium vaccae that has been tested in uses related to inhibiting periodontal disease, in treating asthma and in treating eczema, itching and inflammation. Mycobacterium vaccae is a non-pathogenic, saprophytic bacteria whose antigens can be used to induce peripheral immune activation through the activity...
Investigational
Matched Description: … A specific subset of serotonergic neurons in the interfascicular part of the dorsal raphe nucleus (DRI ... SRP 299 is a preparation of killed Mycobacterium vaccae that has been tested in uses related to inhibiting ... saprophytic bacteria whose antigens can be used to induce peripheral immune activation through the activity of …
Selamectin
Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in dogs as well as prevent heartworms, fleas, ear mites, hookworms, and roundworms in cats. It also removes 2 types of...
Vet approved
Matched Description: … It also removes 2 types of lungworm in cats and one type of lungworm in dogs. ... is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of ... heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in dogs as well as prevent …
BOS172722
BOS172722 is a novel and selective Monopolar spindle 1 (Mps1) kinase inhibitor identified as a potential anticancer agent. Normally, Mps1 supports the proper division of cancer cells, ensuring survival and replication. The key role of Mps1 in the growth of cancer cells renders it an appealing target for cancer treatment,...
Experimental
Matched Description: … The key role of Mps1 in the growth of cancer cells renders it an appealing target for cancer treatment ... [A187123] Normally, Mps1 supports the proper division of cancer cells, ensuring survival and replication ... [A187120] An in vivo study combined BOS172722 with [Paclitaxel] for the treatment of triple hormone …
Temocapril
Temocapril is a prodrug-type angiotensin-I converting enzyme (ACE) inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used in hemodialysis patients without risk of serious accumulation.
Experimental
Investigational
Matched Description: … Temocapril can also be used in hemodialysis patients without risk of serious accumulation. …
Phenserine
Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia. Phenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of AD. Unlike currently marketed AChE inhibitors, it has a dual mechanism of action that also includes anti-amyloid activity, which may confer...
Investigational
Matched Description: … Phenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of ... substantiated in an ongoing clinical trial then phenserine may open the door to an entirely new type of ... Unlike currently marketed AChE inhibitors, it has a dual mechanism of action that also includes anti-amyloid …
DDP733
DDP733 is an oral prokinetic drug which Dynogen is developing as a treatment for both Irritable Bowel Syndrome with constipation (IBS-c) and nocturnal gastroesophageal reflux disease (NGERD). It is a partial agonist of the serotonin type 3 receptor (5-HT3). Serotonin is a neurotransmitter that is known to be involved in...
Investigational
Matched Description: … the motility of the GI tract). ... It is a partial agonist of the serotonin type 3 receptor (5-HT3). ... Serotonin is a neurotransmitter that is known to be involved in the control of the gastrointestinal ( …
AEG35156
A second-generation synthetic antisense oligonucleotide with potential antineoplastic activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed in many tumors. This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome...
Investigational
Matched Description: … AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP) ... , a pivotal inhibitor of apoptosis that is overexpressed in many tumors. ... This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs …
Bambuterol
Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
Investigational
Matched Description: … It is a prodrug of terbutaline. ... Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. …
Giripladib
Giripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee).
Investigational
Matched Description: … PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee). ... Giripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of …
Reloxiliase
Reloxiliase is a first-in-class, oral crystalline formulation of the oxalate-specific, microbial enzyme oxalate decarboxylase. It is being investigated for the treatment of hyperoxaluria.
Investigational
Matched Description: … It is being investigated for the treatment of hyperoxaluria.[A258823] ... Reloxiliase is a first-in-class, oral crystalline formulation of the oxalate-specific, microbial enzyme …
Fibrinolysin
Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of Fibrinolysin; the heavy chain has a molecular weight of approximately 57,000 Da. Fibrinolysin is used as a...
Investigational
Matched Description: … The light chain has a molecular weight of approximately 27,000 Da and contains the active center of Fibrinolysin ... ; the heavy chain has a molecular weight of approximately 57,000 Da. ... Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. …
Indium In-111 satumomab pendetide
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Experimental
Withdrawn
Josamycin
A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
Investigational
Matched Description: … The drug has antimicrobial activity against a wide spectrum of pathogens. …
Camptothecin
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Experimental
Matched Description: … Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. ... Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata …
Isatoribine
Isatoribine is a selective agonist of TLR7.
Investigational
Matched Description: … Isatoribine is a selective agonist of TLR7. …
Olcegepant
Boehringer Ingelheim Pharmaceuticals’ olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of drugs in development for the treatment of acute migraine attacks. Olcegepant is undergoing phase II trials in Europe and the US, with preliminary results suggesting that CGRP antagonists may represent a potential...
Investigational
Matched Description: … drugs in development for the treatment of acute migraine attacks. ... olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of ... preliminary results suggesting that CGRP antagonists may represent a potential new approach to the treatment of …
Metralindole
Metralindole, also known as Inkazan, is similar in structure and pharmacology to pirlindole. It functions as a reversible inhibitor of monoamine oxidase A. In Russia, this drug was investigated for potential antidepressant activity.
Experimental
Matched Description: … It functions as a reversible inhibitor of monoamine oxidase A. …
ABX-PTH
ABX-PTH is a fully human monoclonal antibody generated by Abgenix's technology platform. This drug targets and neutralizes the action of parathyroid hormone (PTH) for the treatment of a secondary hyperparathyroidism.
Investigational
Matched Description: … This drug targets and neutralizes the action of parathyroid hormone (PTH) for the treatment of a secondary …
HMR4011
HMR4011 (IPL 576,092) is a novel steroidal anti-inflammatory compound with a mechanism of action distinct from that of glucocorticoid. IPL 576,092 has previously been investigated as a treatment for asthma.
Investigational
Matched Description: … from that of glucocorticoid. ... HMR4011 (IPL 576,092) is a novel steroidal anti-inflammatory compound with a mechanism of action distinct …
Enzastaurin
Enzastaurin, an investigational, targeted, oral agent, will be evaluated at more than 100 sites worldwide for the treatment of relapsed glioblastoma multiforme (GBM), an aggressive and malignant form of brain cancer.
Investigational
Matched Description: … relapsed glioblastoma multiforme (GBM), an aggressive and malignant form of brain cancer. ... investigational, targeted, oral agent, will be evaluated at more than 100 sites worldwide for the treatment of …
Displaying drugs 4526 - 4550 of 8282 in total