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Displaying drugs 26 - 50 of 10617 in total
Futibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and survival. FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed...
Approved
Investigational
Matched Synonyms: … 1-((3S)-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo(3, 4-d) pyrimidin-1-yl)-1-pyrrolidinyl) ... 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl] ... -2-propen-1-one …
Matched Iupac: … 1-[(3S)-3-{4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl ... ]prop-2-en-1-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols. In particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes.
Approved
Matched Synonyms: … (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine ... 4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine ... N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine …
Matched Iupac: … [(4-tert-butylphenyl)methyl](methyl)[(naphthalen-1-yl)methyl]amine …
Matched Products: … BUTAFLY %1 KREM,15G ... BUTAFLY %1 KREM,30G ... BUTEFIN %1 KREM, 15 G …
Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first...
Approved
Investigational
Matched Synonyms: … 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one ... (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one …
Matched Iupac: … (5S)-3-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(12),9(13),10-trien-2- …
Matched Products: … IÇEREN FLAKON, 1 ADET ... ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON, 1 ADET ... ENJEKSIYONLUK COZELTI ICEREN FLAKON, 1 ADET …
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone. Dexamethasone was granted FDA approval on 30 October 1958....
Approved
Investigational
Vet approved
Matched Synonyms: … 16α-Methyl-9α-fluoro-1-dehydrocortisol ... 1-Dehydro-16α-methyl-9α-fluorohydrocortisone ... 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol …
Matched Iupac: … (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H …
Matched Mixtures name: … . + DEXAMETASONA 1 MG)/1ML ... . + DEXAMETASONA 1 MG)/1ML ... DUODECADRON ® SUSPENSIÓN INYECTABLE 1 ML …
Matched Products: … DEKSOFTAN 1 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET ... ONADRON AMPUL, 1 ADET ... DEXALTIN ORAL PASTE 1 mg/g …
Afamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). It differs structurally from its endogenous counterpart by only two amino acids - these structural differences improve biological efficacy by imparting a greater affinity for its target and a longer biological half-life.[A187202,A187205] Afamelanotide is...
Approved
Investigational
Matched Synonyms: … Melanotan 1 ... Melanotan-1
Matched Iupac: … (4S)-4-{[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl ... ]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl …
Matched Categories: … Melanocortin 1 Receptor (MC1-R) Agonists …
Ritlecitinib (PF-06651600) is a highly selective inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family. In June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adults and adolescents 12 years and older.[L47092,L47127] It was further...
Approved
Investigational
Matched Synonyms: … 2-propen-1-one, 1-((2S,5R)-2-methyl-5-(7H-pyrrolo(2,3-D)pyrimidin-4-ylamino)-1-piperidinyl)- …
Matched Iupac: … 1-[(2S,5R)-2-methyl-5-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)piperidin-1-yl]prop-2-en-1-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes. However, its clinical efficacy as...
Approved
Matched Synonyms: … 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol ... 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-ol …
Matched Iupac: … (1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine. Levocetirizine was granted FDA approval in 1995.
Approved
Matched Synonyms: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Iupac: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Description: … Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic ... [L7694] Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine. …
Matched Mixtures name: … Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2% ... Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05% ... LEVMONT 2.5/4 MG CIGNEME TABLET, 90 ADET …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … LEVOKAST 5 MG/10 MG FILM KAPLI TABLET, 90 ADET …
Bupivacaine is a widely used local anesthetic agent.
Approved
Investigational
Matched Synonyms: … 1-Butyl-2',6'-pipecoloxylidide ... dl-1-Butyl-2',6'-pipecoloxylidide ... 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide …
Matched Iupac: … 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide …
Matched Mixtures name: … Mlp A-1 ... Pro-C-Dure 1 Kit ... Marcaine 0.5% and Epinephrine 1:200,000 Liq …
Matched Products: … BUPİVON % 0,5 ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... BUSACAİN % 0.5 ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... BUVICAINE %0.5 ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON,1 ADET …
Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against Pseudomonas infections. It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, peritonitis, skin infections, endometritis, and bacterial septicemia. While its...
Approved
Investigational
Matched Synonyms: … (6R,7R)-7-((R)-2-(4-Ethyl-2,3-dioxo-1-piperazinylcarboxamido)-2-(4-hydroxyphenyl)acetamido)-3-((1-methyl ... (6R,7R)-7-[[2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1- ... -1H-tetrazol-5-yl)thiomethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure …
Matched Iupac: … 1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic ... (6R,7R)-7-[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetamido]-3-{[( …
Matched Mixtures name: … SEFBAKTAM 1 GR ENJEKTABL FLAKON, 1 FLAKON + 1 AMPUL ... SULZON 1 G IM/IV ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 1 ADET, 1 AMPUL ... SULZON 2G/1 G IM/IV ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 1 ADET, 1 AMPUL …
Matched Products: … CEFOBID 1 GR FLAKON, 1 ADET ... EKOBID 1 G IM/IV ENJEKSIYONLUK TOZ IÇEREN FLAKON , FLAKON, 1 ADET, 1 AMPUL ... STABIXIN-1
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale,...
Approved
Investigational
Matched Synonyms: … 1-beta-D-Arabinofuranosylcytosine ... Cytosine-1-beta-D-arabinofuranoside ... 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone …
Matched Iupac: … 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … CYTARABINE DBL 10 ML 1 GR FLAKON, 1 ADET ... CITARABINA INYECTABLE 100 MG/ 1 ML ... CYTU 1000 MG/ 10 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 1 ADET …
A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
Approved
Matched Synonyms: … 1-propanol ... 1-proponol …
Matched Iupac: … propan-1-ol …
A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Approved
Investigational
Matched Synonyms: … 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol ... alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanol ... alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol …
Matched Iupac: … 1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol …
Matched Salts cas: … 1235-82-1
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher disease, the accumulation of glucosylceramide leads to...
Approved
Investigational
Matched Synonyms: … N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamide …
Matched Iupac: … N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]octanamide …
Matched Description: … Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher ... the FDA in August 2014 as an oral substrate reduction therapy for the first-line treatment of type 1 ... [L41404,A7634] Enzyme replacement continues to be the standard of care for the treatment of type 1 Gaucher …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Vonoprazan is a potassium-competitive acid blocker (PCAB) that inhibits H+, K+-ATPase-mediated gastric acid secretion. PCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders. Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require acid-resistant formulations. Furthermore, vonoprazan is 350-times more potent...
Approved
Investigational
Matched Synonyms: … 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine …
Matched Iupac: … {[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrol-3-yl]methyl}(methyl)amine …
Matched Description: … vonoprazan, amoxicillin, and clarithromycin leads to an _H. pylori_ eradication rate of approximately 90% …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the...
Approved
Matched Synonyms: … 1-deamino-8-D-arginine vasopressin ... 1-desamino-8-D-arginine vasopressin ... 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin …
Matched Iupac: … (2R)-2-{[(2S)-1-[(4R,7S,10S,13S,16S)-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl …
Matched Description: … analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1- …
Matched Products: … EMOSINT 20 MCG / 1 ML SOLUCION INYECTABLE ... OCTOSTIM 30 MCG/2 ML IV/SC ENJEKSIYON IÇIN ÇÖZELTI IÇEREN AMPUL, 1 ADET …
Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to 200 p.p.m. since 1998 according to guidelines issued by...
Approved
Experimental
Matched Synonyms: … 2-methoxy-4-(prop-1-en-1-yl)phenol ... 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene …
Matched Iupac: … 2-methoxy-4-(prop-1-en-1-yl)phenol …
Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound...
Approved
Investigational
Matched Synonyms: … (Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol …
Matched Iupac: … 2-(4-{3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethan-1-ol …
Matched Salts cas: … 58045-23-1
Matched Categories: … Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … SOLUSYON, 1 ML ... CLOPIXOL DEPOT ENJ. 200 MG/ML IM SOLÜSYON, 1 ML …
Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue.
Approved
Matched Synonyms: … 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine ... 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine ... 9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine …
Matched Products: … EX-LOVIR % 1 KREM 2 G ... PENSIVIR %1 KREM , 2 G ... PENSIVIR %1 KREM , 5 G …
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Approved
Investigational
Matched Synonyms: … 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid ... 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid …
Matched Iupac: … 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid …
Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
Approved
Investigational
Matched Synonyms: … 1-methyl-4-piperidyl benzhydryl ether ... 4-(benzhydryloxy)-1-methylpiperidine ... 1-methyl-4-hydroxypiperidine benzhydryl ether …
Matched Iupac: … 4-(diphenylmethoxy)-1-methylpiperidine …
Matched Description: … Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations. However, the development of KRAS inhibitors has been challenging due to their high affinity for guanosine triphosphate (GTP) and guanosine diphosphate...
Approved
Investigational
Matched Synonyms: … )methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2s)- ... ((2s)-4-(7-(8-chloronaphthalen-1-yl)-2-(((2s)-1- methylpyrrolidin-2-yl)methoxy)-5,6,7,8- tetrahydropyrido ... 2-piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2s)-1-methyl-2-pyrrolidinyl …
Matched Iupac: … 2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5H,6H,7H,8H-pyrido[3,4 ... -d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against both compared to third-generation antibiotics.[A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused by multi-resistant microorganisms such as Pseudomonas aeruginosa, and is also indicated...
Approved
Investigational
Matched Synonyms: … -1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate ... (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium …
Matched Iupac: … -1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium ... 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia …
Matched Products: … CEFEPIMA 1 G ... ROXIPIME 1 GR IM/IV ENJEKTABL TOZ ICEREN FLAKON, 1 ADET ... CEFEPEN INJECTION 1 g …
Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism...
Approved
Matched Synonyms: … 1-ethyl N4-sulfanilylcytosin ... 1-ethyl-N-sulfanilylcytosine …
Matched Iupac: … 4-amino-N-(1-ethyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzene-1-sulfonamide …
Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium...
Approved
Investigational
Matched Synonyms: … potassium(1+) ... potassium(1+) ion …
Matched Iupac: … potassium(1+) ion …
Displaying drugs 26 - 50 of 10617 in total