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Displaying drugs 476 - 500 of 9568 in total

Rilonacept

Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome...
Approved
Investigational
Matched Synonyms: … interleukin-1 (IL-1) trap ... IL-1 TRAP ... IL-1-TRAP …
Matched Description: … Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as …
Matched Categories: … Interleukin-1 Blockers ... Receptors, Interleukin-1 Type I ... Interleukin-1 Receptor Accessory Protein …

Trichlormethiazide

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Approved
Vet approved
Matched Iupac: … 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Xenon Xe-127

Approved

Azithromycin

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Iupac: … -heptamethyl-1-oxa-6-azacyclopentadecan-15-one ... ]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14 ... (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl …
Matched Products: … ZITROTEK FILM KAPLI TABLET, 2 ADET ... AZİTROTEK 500 MG FİLM TABLET, 2 TABLET ... ZIROMIN 500 MG IV LIYOFILIZE ENJEKSIYONLUK TOZ IÇEREN FLAKON, 1 FLAKON + 1 ÇÖZÜCÜ AMPUL …

Etacrynic acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop...
Approved
Investigational
Matched Synonyms: … (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid …
Matched Iupac: … 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid …

Motixafortide

Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection prior to autologous transplantation. Hematopoietic stem cell transplantation (HSCT) is commonly employed in the context of hematologic cancers - high-dose chemotherapy regimens destroy cancerous blood cells, which are then replaced via infusion of the patient's...
Approved
Investigational

Hydroxyprogesterone caproate

Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug...
Approved
Investigational
Matched Iupac: … (1R,3aS,3bR,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H, ... 11H,11aH-cyclopenta[a]phenanthren-1-yl hexanoate …
Matched Mixtures name: … GRAVIDINONA 2 ML …
Matched Products: … LUGESRO 500 MG/2 ML ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... PROLUTON DEPOT 500 MG/2ML IM ENJEKSIYONLUK COZELTI ICEREN AMPUL, 1 ADET …

Clofarabine

Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic...
Approved
Investigational
Matched Synonyms: … 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine ... 2-chloro-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine ... (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol …
Matched Iupac: … (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … FARABIN 1 MG/ ML SOLUCIÓNINYECTABLE ... CLOLAR 1 MG/ML SOLUCION CONCENTRADA PARA INFUSION ... CLOLAR® 1 MG/ML SOLUCION CONCENTRADA PARA INFUSION …

Influenza A Virus A/California/122/2022 SAN-022 (H3N2) antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection from influenza viruses. These vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in...
Approved

Halazepam

Halazepam is a benzodiazepine derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by Schering, its manufacturer, in 2009.[L6226, L6229]
Approved
Illicit
Withdrawn
Matched Iupac: … 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Flunitrazepam

Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
Approved
Illicit
Matched Iupac: … 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … ROHYPNOL 1 ... Rohypnol 1 mg - Filmtabletten ... ROHYPNOL ROCHE TABLETAS 1 MG …

Aluminum zirconium tetrachlorohydrex gly

Aluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent. Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.
Approved
Matched Products: … Lady Speed Stick 24/7 …

Solriamfetol

Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label].
Approved
Matched Synonyms: … (2R)-2-amino-3-phenylpropyl carbamate …
Matched Iupac: … (2R)-2-amino-3-phenylpropyl carbamate …
Matched Salts cas: … 178429-65-7 …
Matched Categories: … MATE 1 Substrates …

Tacrolimus

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Iupac: … ]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo ... (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl …
Matched Description: … This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% ... Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1% …
Matched Products: … Adport 2 mg - Hartkapseln ... Dailiport 2 mg - Hartkapseln, retardiert ... DAİLİPORT 2 MG UZATILMIŞ SALIMLI SERT KAPSÜL , 30 ADET …

Latamoxef

Latamoxef is a broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Approved
Investigational
Matched Iupac: … (6R,7R)-7-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl ... ]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Susoctocog alfa

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Description: … In a global, prospective, controlled, multi-center Phase 2/3 open-label clinical trial, all patients …

Oprelvekin

Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid...
Approved
Investigational

Permethrin

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Approved
Investigational
Matched Iupac: … (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate …
Matched Products: … NOBIT % 1 ŞAMPUAN ... A-LICES LOTION 1%w/w ... PIO LAD® 1% CHAMPU …

Choline magnesium trisalicylate

Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28% [A19653, A19654].
Approved
Matched Iupac: … magnesium(2+) (2-hydroxyethyl)trimethylazanium tris(2-hydroxybenzoate) …
Matched Categories: … Non COX-2 selective NSAIDS …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Iupac: … 1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan ... -2-yl)-1H-indol-5-yl}cyclopropane-1-carboxamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …

Plazomicin

Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Iupac: … -2H-pyran-2-yl]oxy}-2-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl ... ]-2-hydroxybutanamide ... (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro …
Matched Description: … and 2-hydroxyethyl group at position 6' [A33942]. ... structure of plazomicin was established via appending hydroxylaminobutyric acid to [DB12604] at position 1 …
Matched Categories: … MATE 1 Inhibitors ... MATE 2 Inhibitors …

Sucrose

A nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons. It is obtained commercially from sugarcane, sugar beet (beta vulgaris), and other plants and used extensively as a food and a sweetener.
Approved
Experimental
Investigational
Matched Synonyms: … 1-alpha-D-Glucopyranosyl-2-beta-D-fructofuranoside …
Matched Iupac: … (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl …

Oxeladin

Withdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.
Approved
Withdrawn
Matched Synonyms: … 2-(2-Diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate …
Matched Iupac: … 2-[2-(diethylamino)ethoxy]ethyl 2-ethyl-2-phenylbutanoate …
Matched Salts cas: … 52432-72-1 …

Methyltestosterone

A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US.
Approved
Matched Iupac: … ,11aH-cyclopenta[a]phenanthren-7-one ... (1S,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H …

Hexachlorophene

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Approved
Withdrawn
Matched Synonyms: … bis(2-hydroxy-3,5,6-trichlorophenyl)methane ... bis(3,5,6-trichloro-2-hydroxyphenyl)methane …
Matched Iupac: … 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol …
Displaying drugs 476 - 500 of 9568 in total