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Displaying drugs 476 - 500 of 11832 in total
Influenza A virus A/Hong Kong/2671/2019 NIB-121 (H3N2) antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Felodipine
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB...
Approved
Investigational
Matched Description: … Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. ... acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in ... By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte …
Casein
Casein allergenic extract is used in allergenic testing.
Approved
Matched Description: … Casein allergenic extract is used in allergenic testing. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Cashew
Cashew allergenic extract is used in allergenic testing.
Approved
Matched Description: … Cashew allergenic extract is used in allergenic testing. …
Amaranthus hybridus pollen
Amaranthus hybridus pollen allergenic extract is used in allergenic testing.
Approved
Matched Description: … Amaranthus hybridus pollen allergenic extract is used in allergenic testing. …
Perflubutane
Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclear stress testing; currently the leading procedure for detecting coronary heart disease.
Approved
Investigational
Matched Description: … Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Thyroid, porcine
Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyroid extract is...
Approved
Matched Description: … [A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891[ ... [A190813]
Thyroid extracts were never FDA approved as their use in the United States predates the …
Melphalan
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. ... [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group …
Technetium Tc-99m pertechnetate
Technetium Tc-99m pertechnetate is a radiopharmaceutical diagnostic agent composed of an oxoanion with the chemical formula TcO4-. Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to a similar extent as iodine. It also concentrates in the thyroid gland, salivary glands, gastric mucosa,...
Approved
Investigational
Matched Description: … It also concentrates in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus. ... However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid ... This is normally supplied in a hospital setting through the use of a technetium-99m generator, whereby …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Moxidectin
Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an approved use in general animals. It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of...
Approved
Investigational
Vet approved
Matched Description: … It was first used in cattle followed by an approved use in general animals. ... [A33385] Moxidectin was developed by Medicines Development for Global Health and FDA approved in June …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Hexobendine
Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has been used widely in Austria and Germany .
Approved
Matched Description: … It has not been approved in the United States or the United Kingdom, but has been used widely in Austria …
Matched Categories: … Vasodilators Used in Cardiac Diseases …
Matched Categories: … Vasodilators Used in Cardiac Diseases …
Polyethylene glycol 400
Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily in topical dermatological preparations. PEGs, along with their many nonionic derivatives, are...
Approved
Matched Description: … many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily in ... PEGs, along with their many nonionic derivatives, are widely utilized in cosmetic products as surfactants ... It is used in ophthalmic solutions for the relief of burning, irritation and/or discomfort that follows …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Amikacin
Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A. Amikacin's unique property is that it exerts activity against more resistant gram-negative bacilli such as...
Approved
Investigational
Vet approved
Matched Description: … label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C- ... M. avium-intracellulare (MAC) is a type of nontuberculous mycobacteria (NTM) found in water and soil. ... [F1949] In September 2018, a liposomal inhalation suspension of this drug was approved by the FDA for …
Sparsentan
Sparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETAR and 0.8 nM for AT1R).[A257330,L45300] Sparsentan is first in its class and orally active, and was created by...
Approved
Investigational
Matched Description: … [A257330]
In February 2023, the use of sparsentan to reduce proteinuria in adults with primary immunoglobulin ... the reduction of proteinuria in patients with IgAN and focal segmental glomerulosclerosis (FSGS). ... Furthermore, it is the first non-immunosuppressive therapy for the reduction of proteinuria in IgAN. …
Benfotiamine
Benfotiamine has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
Trichloroethylene
Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic and as an inhaled obstetrical analgesic. Environmental exposure,...
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …
Tovorafenib
Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation,...
Approved
Investigational
Matched Description: … [L50587] BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation, and differentiation …
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of...
Approved
Illicit
Matched Description: … It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in …
Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Phenformin
A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Approved
Investigational
Withdrawn
Matched Description: … associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in …
Matched Categories: … Drugs Used in Diabetes …
Matched Categories: … Drugs Used in Diabetes …
Technetium Tc-99m tetrofosmin
Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin. It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit...
Approved
Matched Description: … Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Fruquintinib
Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathway is one of the most critical pathways for this phenomenon.[A262102,A262107] Indeed, oncogenic activation,...
Approved
Investigational
Matched Description: … overall survival rate was observed in both trials. ... approval is based on favorable results obtained from the FRESCO and FRESCO-2 trials, where an increase in ... Although [bevacizumab] is successful in sustaining target inhibition, mandatory intravenous dosing, immunogenicity …
Gemeprost
Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in...
Approved
Withdrawn
Matched Description: … It is not FDA-approved but available in Japan marketed as Preglandin. ... It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone …
Miglitol
Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.
Miglitol should be taken at the start...
Approved
Matched Description: … It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing ... of a meal for maximal effect and the effect will depend on the amount of poly and oligosaccharides in …
Matched Categories: … Drugs Used in Diabetes …
Matched Categories: … Drugs Used in Diabetes …
Meglumine
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …
Displaying drugs 476 - 500 of 11832 in total