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Displaying drugs 526 - 550 of 14030 in total

Cetalkonium

Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations. It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. Cetalkonium is approved by the FDA for its use...
Approved
Matched Description: … [L2137] Cetalkonium is approved by the FDA for its use in over-the-counter products as a skin protectant ... [L2737] By Health Canada, it is also approved for its use in over-the-counter products.[L1113] ... it to be used in different types of formulations. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ethambutol

Ethambutol is a bacteriostatic agent indicated alongside medications such as isoniazid, rifampin, and pyrazinamide in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of Mycobacterium tuberculosis. Ethambutol was granted FDA...
Approved
Matched Description: … [A229048] It was developed out of a need for therapies active against isoniazid resistant strains of ... [L31743] Ethambutol was first described in the literature in 1961. ... Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], …
Matched Categories: … Antiinfectives for Systemic Use ... Drugs for Treatment of Tuberculosis …

Ethynodiol diacetate

A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug that has never been...
Approved
Matched Iupac: … -7-(acetyloxy)-1-ethynyl-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive ... Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually ... being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug that …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Vaborbactam

Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. It has been used in trials investigating the treatment of bacterial infections in subjects with varying degrees of renal insufficiency. In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for...
Approved
Investigational
Matched Description: … In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the ... Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. ... [A32053] It has been used in trials investigating the treatment of bacterial infections in subjects with …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Propiolactone

Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently...
Approved
Withdrawn
Matched Description: … [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances ... Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, ... Propiolactone was first commercially available in the United States in 1958.[A32144] …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cocaine

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of...
Approved
Illicit
Matched Description: … It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in ... It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse …

Metrizoic acid

Metrizoic acid is a molecule used as a contrast medium. It present a higher risk of allergic reactions due to its high osmolality. Its approval has been discontinued by the FDA. One study in 1976 demonstrated that metrizoic acid, when used for cardiac angiography, was well tolerated. A total of...
Approved
Matched Description: … One study in 1976 demonstrated that metrizoic acid, when used for cardiac angiography, was well tolerated ... With two exceptions, all complications occurred during injection of the right coronary artery. ... Metrizoic acid is a molecule used as a contrast medium. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Plazomicin

Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … On June 28th, 2018, plazomicin sulfate was approved by the FDA for use in adult patients for the treatment ... Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically ... It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to …
Matched Categories: … Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Tetracaine

Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Approved
Vet approved
Matched Description: … Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Anesthetics for Topical Use …

Atoltivimab

Ebola virus (EBOV) remains an important human pathogen within the Ebolavirus genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid...
Approved
Matched Description: … All three mAbs bind to a distinct portion of the GP1,2 glycoprotein and collectively provide ... of antibodies were important for therapeutic benefit in animal models of EBOV infection. ... role in combatting EBOV infection. …
Matched Categories: … Treatments for Ebola Virus Disease …

Oxycodone

Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The first oxycodone...
Approved
Illicit
Investigational
Matched Description: … Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. ... for an extended period. ... [A178696] It is currently indicated as an immediate release product for moderate to severe pain and as …
Matched Products: … Oxynorm 10mg/ml Solution for Injection or Infusion ... Sterile Solution for Injection or Infusion 10mg/ml ... OXYCODONE WOCKHARDT SOLUTION FOR INJECTION OR INFUSION 10MG/ML …

Clozapine

Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical". . This low affinity to dopamine receptors results in fewer extrapyramidal side effects,...
Approved
Matched Description: … [A256718] Clozapine was approved by the FDA in 1989 for treatment-resistant schizophrenia under the ... was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis. ... Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. …

Acrivastine

Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema, bronchoconstriction, and tachycardia. Acrivastine is...
Approved
Matched Description: … Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever ... Acrivastine is currently available in combination with pseudoephedrine as the FDA-approved product Semprex-D …
Matched Categories: … Antihistamines for Systemic Use …

Alogliptin

Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Approved
Matched Description: … It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. ... Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase ... Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (> …
Matched Categories: … Drugs Used in Diabetes …

Prednisone

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone was granted FDA approval on 21 February 1955.
Approved
Vet approved
Matched Iupac: … hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. ... [A187463] It is biologically inert and converted to [prednisolone] in the liver. …
Matched Categories: … Medications that reduce magnesium levels ... Corticosteroids for Systemic Use ... Corticosteroids for Systemic Use, Plain …

Pentastarch

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it...
Approved
Investigational
Matched Description: … When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a ... It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Repaglinide

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood...
Approved
Investigational
Matched Description: … Meglitnides may have a neutral effect on weight or cause a slight increase in weight. ... Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine. ... Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. …
Matched Categories: … Drugs Used in Diabetes …

Pitolisant

Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnagogic hallucinations. About...
Approved
Investigational
Matched Description: … In a European clinical trial of adult patients with narcolepsy, there was a reduction in the Epworth ... FDA approved the use of pitolisant in 2019 for excessive daytime sleepiness (EDS) associated with narcolepsy ... ] for the treatment of narcolepsy with or without cataplexy. …

Tannic acid

Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine....
Approved
Matched Description: … It acts as a weak acid. ... Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. ... In the old days it was used as antidote against different poisons. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Elbasvir

Elbasvir is a direct-acting antiviral medication used as part of combination therapy to treat chronic hepatitis C, an infectious liver disease caused by infection with hepatitis C virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in...
Approved
Matched Description: … being the most common in the United States, affecting 72% of all chronic HCV patients. ... [A19626] In a computational target-based drug repurposing investigation published in April 2020, elbasvir ... Approved in January 2016 by the FDA, Zepatier is indicated for the treatment of HCV genotypes 1 and 4 …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Treatments for Hepatitis C ... Antivirals for treatment of HCV infections ... Experimental Unapproved Treatments for COVID-19 …

Apadamtase alfa

Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Description: … <5% of all cases of TTP. ... ADAMTS13 plasma levels. ... November 2023 for use as an enzyme replacement therapy in patients with cTTP. …

Hydroxyamphetamine

Hydroxyamphetamine is a derivative of amphetamines. Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. Among the minor side effects from its use are: change in color vision, difficulty seeing at night, dry...
Approved
Matched Description: … Hydroxyamphetamine is a derivative of amphetamines. ... Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. ... Among the minor side effects from its use are: change in color vision, difficulty seeing at night, dry …

Eprosartan

Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Approved
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Urokinase

Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978.
Approved
Investigational
Withdrawn
Matched Description: … [A191943] Urokinase remains connected between these 2 chains by a sulfhydryl bond. ... Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and …
Matched Products: … Kinlytic (urokinase for Injection) …

Corticorelin ovine triflutate

Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary...
Approved
Matched Description: … It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ... It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation ... Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the …
Matched Categories: … Tests for Pituitary Function …
Displaying drugs 526 - 550 of 14030 in total