Displaying drugs 551 - 575 of 706 in total
5-O-phosphono-alpha-D-ribofuranosyl diphosphate
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Approved
Experimental
Investigational
Matched Synonyms: … 5-O-phosphono-α-D-ribofuranosyl diphosphate …
Matched Name: … 5-O-phosphono-alpha-D-ribofuranosyl diphosphate …
Matched Iupac: … [({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic …
Matched Description: … The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides …
Matched Name: … 5-O-phosphono-alpha-D-ribofuranosyl diphosphate …
Matched Iupac: … [({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic …
Matched Description: … The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides …
2,3-Di-O-Sulfo-Alpha-D-Glucopyranose
Experimental
Matched Name: … 2,3-Di-O-Sulfo-Alpha-D-Glucopyranose …
Beta-1,2,3,4,6-Penta-O-Galloyl-D-Glucopyranose
Experimental
Matched Name: … Beta-1,2,3,4,6-Penta-O-Galloyl-D-Glucopyranose …
[4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE]
Experimental
Matched Name: … [4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE] …
Bitolterol
Bitolterol mesylate was used to treat bronchospasms in asthma and COPD. It is a beta-2-adrenergic receptor agonist. Bitolterol was withdrawn from the market by Elan Pharmaceuticals in 2001.
Withdrawn
Matched Synonyms: … 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene di-p-toluate ... 4-[2-(tert-butylamino)-1-hydroxyethyl]-o-phenylene di-p-toluate …
Matched Description: … Bitolterol mesylate was used to treat bronchospasms in asthma and COPD. …
Matched Description: … Bitolterol mesylate was used to treat bronchospasms in asthma and COPD. …
Gemcitabine elaidate
Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma.
Investigational
Matched Synonyms: … 5'-O-(trans-9"-octadecenoyl)-1-beta-D-2'deoxy-2',2'-difluorocytidine ... 5'-O-(TRANS-9''-OCTADECENOYL)-1-.BETA.-D-2'DEOXY-2',2'-DIFLUOROCYTIDINE …
Matched Iupac: … [(2R,3R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl (9E) …
Matched Description: … Lung Cancer, and Metastatic Pancreatic Adenocarcinoma. ... Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … [(2R,3R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl (9E) …
Matched Description: … Lung Cancer, and Metastatic Pancreatic Adenocarcinoma. ... Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Mitotane
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the...
Approved
Matched Synonyms: … o,p'-DDD …
Matched Description: … metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their ... It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is ... used off-label for the management of Cushing's syndrome. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their ... It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is ... used off-label for the management of Cushing's syndrome. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
WP-1122
WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). It was granted FDA orphan designation for the treatment of glioblastoma multiforme.
Investigational
Matched Synonyms: … 3,6-di-O-acetyl-2-deoxy-D-glucopyranose ... an acetic acid diester of 2-deoxy-D-glucose …
Matched Description: … WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). ... It was granted FDA orphan designation for the treatment of glioblastoma multiforme.[L47361] …
Matched Description: … WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). ... It was granted FDA orphan designation for the treatment of glioblastoma multiforme.[L47361] …
Oxaliplatin
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride...
Approved
Investigational
Matched Synonyms: … L-OHP …
Matched Description: … [A797] Oxaliplatin was approved by the FDA on January 9, 2004 and is currently marketed by Sanofi-Aventis ... refractory to an initial fluorouracil and leucovorin combination. ... Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … AL OXA ® SOLUCION CONCENTRADA PARA INFUSION ... O-PLAT 50 MG POLVO LIOFILIZADO PARA INYECC ION ... O-PLAT 100 MG POLVO LIOFILIZADO PARA INYECCION …
Matched Description: … [A797] Oxaliplatin was approved by the FDA on January 9, 2004 and is currently marketed by Sanofi-Aventis ... refractory to an initial fluorouracil and leucovorin combination. ... Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … AL OXA ® SOLUCION CONCENTRADA PARA INFUSION ... O-PLAT 50 MG POLVO LIOFILIZADO PARA INYECC ION ... O-PLAT 100 MG POLVO LIOFILIZADO PARA INYECCION …
Tetracycline
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the...
Approved
Vet approved
Withdrawn
Matched Description: … and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. ... It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane ... [L43942] Other formulations of tetracycline continue to be used. …
Matched Mixtures name: … Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride ... Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride …
Matched Categories: … combinations of tetracyclines ... Alimentary Tract and Metabolism ... tetracycline and oleandomycin ... Ophthalmological and Otological Preparations ... lansoprazole, tetracycline and metronidazole …
Matched Products: … MeaStem First Aid and Antibiotic ... Achromycin Ont Oph 1% …
Matched Mixtures name: … Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride ... Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride …
Matched Categories: … combinations of tetracyclines ... Alimentary Tract and Metabolism ... tetracycline and oleandomycin ... Ophthalmological and Otological Preparations ... lansoprazole, tetracycline and metronidazole …
Matched Products: … MeaStem First Aid and Antibiotic ... Achromycin Ont Oph 1% …
Novobiocin
Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964...
Approved
Investigational
Vet approved
Withdrawn
Matched Synonyms: … N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-β-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen …
Matched Iupac: … -2H-chromen-7-yl}oxy)-3-methoxy-2,2-dimethyloxan-4-yl carbamate ... (3R,4S,5R,6R)-5-hydroxy-6-({4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2-oxo …
Matched Description: … novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious ... Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. ... In 2009, the FDA determined novobiocin sodium was withdrawn from sale for reasons of safety or effectiveness …
Matched Iupac: … -2H-chromen-7-yl}oxy)-3-methoxy-2,2-dimethyloxan-4-yl carbamate ... (3R,4S,5R,6R)-5-hydroxy-6-({4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2-oxo …
Matched Description: … novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious ... Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. ... In 2009, the FDA determined novobiocin sodium was withdrawn from sale for reasons of safety or effectiveness …
Adenosine 5'-[gamma-thio]triphosphate
A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur.
Experimental
Matched Synonyms: … Adenosine 5-O-(3-thiotriphophate) ... Adenosine 5'-O-(3-thiotriphosphate) …
Matched Iupac: … ](hydroxy)phosphoryl}oxy)phosphonothioic acid ... ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy …
Matched Description: … A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group …
Matched Categories: … Indicators and Reagents ... Nucleic Acids, Nucleotides, and Nucleosides ... Compounds used in a research, industrial, or household setting …
Matched Iupac: … ](hydroxy)phosphoryl}oxy)phosphonothioic acid ... ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy …
Matched Description: … A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group …
Matched Categories: … Indicators and Reagents ... Nucleic Acids, Nucleotides, and Nucleosides ... Compounds used in a research, industrial, or household setting …
Esculin
Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculin belongs to the family of Glycosyl...
Approved
Matched Synonyms: … Esculetin 6-O-glucoside ... 6,7-Dihydroxycoumarin-6-O-glucoside ... 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one …
Matched Iupac: … 7-hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2H-chromen-2-one …
Matched Description: … naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and ... , or Se- glycosidic bond. ... Esculin belongs to the family of Glycosyl Compounds. …
Matched Mixtures name: … Proctosone Ont …
Matched Iupac: … 7-hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2H-chromen-2-one …
Matched Description: … naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and ... , or Se- glycosidic bond. ... Esculin belongs to the family of Glycosyl Compounds. …
Matched Mixtures name: … Proctosone Ont …
Adenosine
The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by dipyridamole and [regadenson].[A229833,A229838] Adenosine...
Approved
Investigational
Matched Description: … L31983] though it is rarely used in this indication, having largely been replaced by [dipyridamole] and ... [L31998]
Adenosine was granted FDA approval on 30 October 1989.[L31978] ... The structure of adenosine was first described in 1931,[A229823] though the vasodilating effects were …
Matched Mixtures name: … Lip And Hand Camellia ... Lip And Hand Wild Rose ... Lip And Hand Shea Butter …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … misoli Power Snail and Collagen Hydrog el Mask Pack ... rootree Treetherapy Rejuvenating Eye and Neck Treatment ... Oozoo Face Serum Alpha One Nutrient …
Matched Mixtures name: … Lip And Hand Camellia ... Lip And Hand Wild Rose ... Lip And Hand Shea Butter …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … misoli Power Snail and Collagen Hydrog el Mask Pack ... rootree Treetherapy Rejuvenating Eye and Neck Treatment ... Oozoo Face Serum Alpha One Nutrient …
Deslanoside
Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
Approved
Matched Synonyms: … 3-[(O-β-D-glucopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl ... -(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-3β,5β,12β-card-20(22)-enolide ... dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy …
Matched Iupac: … }oxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta ... [a]phenanthren-1-yl]-2,5-dihydrofuran-2-one ... {[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy …
Matched Description: … A cardiotonic glycoside from the leaves of Digitalis lanata. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Iupac: … }oxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta ... [a]phenanthren-1-yl]-2,5-dihydrofuran-2-one ... {[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy …
Matched Description: … A cardiotonic glycoside from the leaves of Digitalis lanata. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
beta-D-fructofuranose 1,6-bisphosphate
Experimental
Matched Synonyms: … 1,6-di-O-phosphono-β-D-fructofuranose …
Teniposide
Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic...
Approved
Matched Synonyms: … 4'-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside) …
Matched Iupac: … -{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy ... hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one …
Matched Description: … Teniposide acts primarily in the G2 and S phases of the cycle. ... Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead ... Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … -{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy ... hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one …
Matched Description: … Teniposide acts primarily in the G2 and S phases of the cycle. ... Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead ... Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
Experimental
Matched Name: … 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME …
Dapiprazole
Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
Approved
Matched Synonyms: … 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine …
Matched Categories: … Antiglaucoma Preparations and Miotics …
Matched Categories: … Antiglaucoma Preparations and Miotics …
MB07133
Investigational
Matched Synonyms: … (2R,4S)-4-amino-1-(5-O-(2-oxo-4-(4-pyridyl)-1,3,2-dioxaphosphorinan-2-yl)-beta-d-arabinofuranosyl)-2( ... 4-amino-1-(5-o-((2r, 4s)-2-oxido-4-(4-pyridinyl)-1, 3, 2-dioxaphosphorinan-2-yl)-.beta. ... 2(1h)-pyrimidinone, 4-amino-1-(5-o-((2r,4s)-2-oxido-4-(4-pyridinyl)-1,3,2-dioxaphosphorinan-2-yl)-.beta …
Matched Iupac: … -2-yl]oxy}methyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one ... 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-({[(2S,4S)-2-oxo-4-(pyridin-4-yl)-1,3,2lambda5-dioxaphosphinan …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … -2-yl]oxy}methyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one ... 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-({[(2S,4S)-2-oxo-4-(pyridin-4-yl)-1,3,2lambda5-dioxaphosphinan …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Thimerosal
Thiomersal (INN), commonly known in the U.S. as thimerosal, is an organomercury compound. This compound is a well-established and widely used antiseptic and antifungal agent.
Developed in 1927, thimerosal has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes...
Approved
Matched Synonyms: … [(o-carboxyphenyl)thio]ethylmercury sodium salt ... o-(ethylmercurithio)benzoic acid sodium salt …
Matched Description: … This compound is a well-established and widely used antiseptic and antifungal agent. ... pharmaceuticals, and biological drug products, which includes vaccines. ... There has been significant concern regarding its safety and toxicity in the last several decades. …
Matched Categories: … Antiseptics and Disinfectants ... Compounds used in a research, industrial, or household setting …
Matched Description: … This compound is a well-established and widely used antiseptic and antifungal agent. ... pharmaceuticals, and biological drug products, which includes vaccines. ... There has been significant concern regarding its safety and toxicity in the last several decades. …
Matched Categories: … Antiseptics and Disinfectants ... Compounds used in a research, industrial, or household setting …
Etizolam
Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983...
Experimental
Matched Synonyms: … 4-(o-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepine …
Matched Description: … and skeletal muscle relaxant properties. ... disorders, etizolam is marketed in Japan, Italy and India. ... It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …
Matched Description: … and skeletal muscle relaxant properties. ... disorders, etizolam is marketed in Japan, Italy and India. ... It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …
Displaying drugs 551 - 575 of 706 in total