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Displaying drugs 551 - 575 of 14622 in total

Tixocortol

Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.
Approved
Withdrawn
Matched Description: … mineralocorticoid activities and toxicity. ... is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and …
Matched Categories: … Alimentary Tract and Metabolism ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Pantethine

Pantethine is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine. It consists of two molecules of pantetheine that form a dimer via disufide linkages, and acts as an intermediate in the production of Coenzyme A. Coenzyme A plays an essential role...
Approved
Investigational
Matched Description: … Pantethine is available as a dietary supplement for lowering blood cholesterol and triglycerides. ... Coenzyme A plays an essential role as a cofactor in the metabolism of lipids and carbohydrates including ... fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, and amino acid catabolism [A27255 …
Matched Categories: … Alimentary Tract and Metabolism …

Laropiprant

Laropiprant is an ingredient in the EMA-withdrawn product Pelzont.
Approved
Investigational
Withdrawn

Deflazacort

Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which...
Approved
Investigational
Matched Description: … This disease can cause serious muscle weakness and progressive breathing and cardiovascular disability ... , severely impacting patient quality of life and survival. ... It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA. …
Matched Categories: … Sex Hormones and Insulins …

Sodium tartrate

Sodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals. It is obtained as a byproduct of wine manufacturing. Sodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient. It acts as an emulsifier and pH...
Approved
Matched Description: … It acts as an emulsifier and pH control agent in food products [L2590]. ... tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and ... This compound is commonly used as an emulsifier in cheese/cheese spread products and is not to exceed …
Matched Categories: … Alimentary Tract and Metabolism …

L-Lactic acid

Approved
Experimental

Betamethasone phosphate

Betamethasone phosphate is a prodrug that is rapidly hydrolyzed, providing rapidly accessible betamethasone to agonize glucocorticoid receptors. Betamethasone provides greater anti-inflammatory activity than prednisolone with less sodium and water retention. Betamethasone sodium phosphate was granted FDA approval on 3 March 1965.
Approved
Vet approved
Matched Description: … L11994] Betamethasone provides greater anti-inflammatory activity than [prednisolone] with less sodium and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Interferon alfa-n1

Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Metixene

Metixene (or methixene) is a anticholinergic used as an antiparkinsonian agent.
Approved
Matched Salts name: … Metixene hydrochloride …

Quinethazone

Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.
Approved
Matched Description: … Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia. …
Matched Categories: … quinethazone and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Celiprolol

Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. It is simultaneously a selective β1 receptor antagonist, a β2 receptor partial agonist and a weak α2 receptor antagonist. In 2010 a clinical trial has suggested a use for this medication in the prevention of...
Approved
Investigational
Matched Description: … Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina ... It is simultaneously a selective β1 receptor antagonist, a β2 receptor partial agonist and a weak α2 …
Matched Salts name: … Celiprolol hydrochloride …

Drotaverine

Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). It is a benzylisoquinoline derivative that is structurally related to papaverine, although it displays more potent antispasmodic activities than papaverine. Drotaverine has been used in the symptomatic treatment of various spastic conditions, such as gastrointestinal diseases, biliary dyskinesia, and...
Approved
Investigational
Matched Description: … [A7036] It also has been investigated in dysmenorrhea, abortion, [A231609] and augmentation of labour ... recently, drotaverine gained attention in the treatment of benign prostatic hyperplasia, parainfluenza, and ... symptomatic treatment of various spastic conditions, such as gastrointestinal diseases, biliary dyskinesia, and …
Matched Salts name: … Drotaverine hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... Papaverine and Derivatives …

Ertugliflozin

Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.
Approved
Investigational
Matched Categories: … Alimentary Tract and Metabolism ... metformin and ertugliflozin ... sitagliptin and ertugliflozin …

Solriamfetol

Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label].
Approved
Matched Description: … Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and …
Matched Salts name: … Solriamfetol hydrochloride …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Dopamine And Norepinephrine Reuptake Inhibitors ... Psychostimulants, Agents Used for ADHD and Nootropics …

Berotralstat

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat is strictly used to...
Approved
Matched Description: … pediatric patients 12 years and older. ... activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and ... [L26661] Berotralstat was approved by the European Commission on April 30, 2021 [L41965] and by Health …
Matched Salts name: … Berotralstat hydrochloride …
Matched Categories: … Blood and Blood Forming Organs …

Iptacopan

Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor B. Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and subsequently C5 convertase. This is...
Approved
Investigational
Matched Description: … the glycosyl phosphatidylinositol–anchored proteins that normally anchor 2 membrane proteins, CD55 and ... Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and ... , where 82.3% and 77.5% of patients experienced a sustained hemoglobin improvement without transfusions …
Matched Salts name: … Iptacopan hydrochloride monohydrate …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Terconazole

Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a triazole ketal derivative. Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels...
Approved
Matched Description: … [FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels ... of safety, efficacy, and tolerability in clinical trials. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Defibrotide

Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of...
Approved
Investigational
Matched Description: … It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without ... It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries. …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …

Sodium acetate

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct...
Approved
Investigational
Matched Description: … It can be used also in metabolic acidosis and for urine alkalinization. ... Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in …
Matched Mixtures name: … Plasma-Lyte 148 and dextrose ... Normosol-R and Dextrose ... Plasma-Lyte M and Dextrose …
Matched Categories: … Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Plasminogen

Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond...
Approved
Matched Description: … [L34615] It is the first and only FDA-approved treatment for this condition, which causes wood-like lesions …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …

Metipranolol

A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Approved
Matched Description: … A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. ... It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent. …
Matched Salts name: … Metipranolol hydrochloride …
Matched Categories: … Beta Blocking Agents and Thiazides ... Antiglaucoma Preparations and Miotics ... metipranolol and thiazides, combinations ... Beta Blocking Agents, Non-Selective, and Thiazides …

Acetohexamide

A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Approved
Investigational
Withdrawn
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … it was approved by the FDA and EMA in August 2012 and February 2013, respectively. ... composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and ... sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrates and …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Hexachlorophene

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Approved
Withdrawn
Matched Description: … It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders …
Matched Categories: … Phenol and Derivatives ... Antiseptics and Disinfectants …

Miltefosine

Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. It can be administered topically or orally and...
Approved
Investigational
Matched Description: … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of ... It can be administered topically or orally and is only indicated in patients aged 12 years or older. ... first line treatment for free-living amebae (FLA) infections such as primary amebic meningoencephalitis and …
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …
Displaying drugs 551 - 575 of 14622 in total