DB00340ApprovedSmall molecule
Metixene (or methixene) is a anticholinergic used as an antiparkinsonian agent.
- Mechanism
- Curator reviewed
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.
- Primary indication
- Used for the symptomatic treatment of parkinsonism.Curator reviewed
- Formula / weight
- C20H23NS · 309.468 g/mol (avg)
- Also known as
- Methixene
- Code names
- 60 SJ 1977
Resolves to
Clinical / RWD
Structure
InChIKey
MJFJKKXQDNNUJF-UHFFFAOYSA-NSMILESCN1CCCC(CC2C3=CC=CC=C3SC3=CC=CC=C23)C1Targets
What you can answer from here — as of September 13, 2026
3Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Metixene, and which of those have an active Phase 3 trial?
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