Displaying drugs 601 - 625 of 1984 in total
Teprasiran
Teprasiran is under investigation in clinical trial NCT03510897 (QPI-1002 Phase 3 for Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery).
Investigational
Matched Synonyms: … Synthetic double-stranded siRNA oligonucleotide directed against p53 mRNA …
Matched Description: … Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery). ... Teprasiran is under investigation in clinical trial NCT03510897 (QPI-1002 Phase 3 for Prevention of Major …
Matched Description: … Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery). ... Teprasiran is under investigation in clinical trial NCT03510897 (QPI-1002 Phase 3 for Prevention of Major …
LV-SMENP Vaccine
LV-SMENP-DC is a vaccine candidate being developed by Shenzhen Geno-Immune Medical Institute that comprises dendritic cells that are modified with lentiviral vector-expressing synthetic minigene which are based on domains of selected viral proteins. This vaccine is also administered with antigen-specific cytotoxic T lymphocytes (CTLs).
As of August 2020, this vaccine...
Investigational
Matched Synonyms: … Covid-19 Synthetic Minigene Vaccine …
Matched Description: … Medical Institute that comprises dendritic cells that are modified with lentiviral vector-expressing synthetic ... As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Matched Description: … Medical Institute that comprises dendritic cells that are modified with lentiviral vector-expressing synthetic ... As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Empegfilgrastim
Empegfilgrastim is under investigation in clinical trial NCT01569087 (Dose-finding Study of Empegfilgrastim for Neutropenia Prophylaxis in Patients With Breast Cancer).
Investigational
Matched Synonyms: … Colony-stimulating factor, granulocyte (synthetic human), 30-kilodalton pegylated …
Matched Description: … Empegfilgrastim is under investigation in clinical trial NCT01569087 (Dose-finding Study of Empegfilgrastim for …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … Empegfilgrastim is under investigation in clinical trial NCT01569087 (Dose-finding Study of Empegfilgrastim for …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Minaprine
Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Approved
Matched Synonyms: … 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine ... N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine …
Matched Description: … amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Matched Description: … amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Phenylbutyric acid
Phenylbutyric acid is a fatty acid and a derivative of butyric acid naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders.[L386,L42105]
Approved
Investigational
Matched Synonyms: … 4-Phenyl-n-butyric acid ... γ-Phenyl-n-butyric acid …
Matched Description: … It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting ... Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria ... [A249035] It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders. …
Matched Categories: … Alimentary Tract and Metabolism ... sodium phenylbutyrate and ursodoxicoltaurine ... Various Alimentary Tract and Metabolism Products …
Matched Description: … It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting ... Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria ... [A249035] It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders. …
Matched Categories: … Alimentary Tract and Metabolism ... sodium phenylbutyrate and ursodoxicoltaurine ... Various Alimentary Tract and Metabolism Products …
Pipequaline
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It presents a unique chemical structure that does not follow the structural properties of other drugs of its class. Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. However, it...
Experimental
Matched Synonyms: … 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline …
Matched Iupac: … 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline …
Matched Description: … Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. …
Matched Iupac: … 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline …
Matched Description: … Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. …
6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid
Experimental
Matched Name: … 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid …
Matched Iupac: … (4R)-6-phenyl-4-(7-phenylheptanamido)hexanoic acid …
Matched Iupac: … (4R)-6-phenyl-4-(7-phenylheptanamido)hexanoic acid …
(1S)-menthyl hexyl phosphonate group
Experimental
Matched Name: … (1S)-menthyl hexyl phosphonate group …
Benzoin resin
Benzoin resin is a balsamic resin obtained from the bark of several species of trees in the genus Styrax. There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different species of the Styrax tree. While benzoin resin is used as a common ingredient...
Approved
Matched Synonyms: … Benzoin resin, unspecified …
Matched Description: … There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different ... While benzoin resin is used as a common ingredient in incense-making and perfumery, it is also used clinically ... as a mild antiseptic agent in over-the-counter products to clean sores, cuts, wounds, and skin abrasions …
Matched Description: … There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different ... While benzoin resin is used as a common ingredient in incense-making and perfumery, it is also used clinically ... as a mild antiseptic agent in over-the-counter products to clean sores, cuts, wounds, and skin abrasions …
SRT-1720
SRT-1720 is an activator of NAD(+)-dependent histone deacetylase SIRT1.
Investigational
Matched Synonyms: … 2-quinoxalinecarboxamide, n-(2-(3-(1-piperazinylmethyl)imidazo(2,1-b)thiazol-6-yl)phenyl)- ... N-(2-(3-(1-piperazinylmethyl)imidazo(2,1-b)thiazol-6-yl)phenyl)-2-quinoxalinecarboxamide …
Matched Iupac: … N-(2-{3-[(piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)quinoxaline-2-carboxamide …
Matched Iupac: … N-(2-{3-[(piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)quinoxaline-2-carboxamide …
Norclobazam
Investigational
Matched Synonyms: … 1h-1,5-benzodiazepine-2,4(3h,5h)-dione, 8-chloro-1-phenyl-7-chloro-5-phenyl-1,2,4,5-tetrahydro-3h-1,5 …
Matched Iupac: … 8-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione …
Matched Iupac: … 8-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione …
AB-8939
Investigational
Matched Synonyms: … 1-(4-(2-(5-ethoxymethyl-2-methyl-phenylamino)-oxazol-5-yl)-phenyl)-imidazolidin-2-one ... 2-imidazolidinone, 1-(4-(2-((5-(ethoxymethyl)-2-methylphenyl)amino)-5-oxazolyl)phenyl)- …
Matched Iupac: … 1-[4-(2-{[5-(ethoxymethyl)-2-methylphenyl]amino}-1,3-oxazol-5-yl)phenyl]imidazolidin-2-one …
Matched Iupac: … 1-[4-(2-{[5-(ethoxymethyl)-2-methylphenyl]amino}-1,3-oxazol-5-yl)phenyl]imidazolidin-2-one …
Cinacalcet
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Approved
Matched Synonyms: … (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine ... N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine …
Matched Iupac: … [(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoromethyl)phenyl]propyl})amine …
Matched Description: … and as Mimpara® in Europe. ... Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Iupac: … [(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoromethyl)phenyl]propyl})amine …
Matched Description: … and as Mimpara® in Europe. ... Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Vismodegib
Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO).[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. Since it targets the hedgehog signaling pathway, vismodegib...
Approved
Investigational
Matched Synonyms: … 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide ... Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)- …
Matched Iupac: … 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide …
Matched Description: … Afterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells. ... Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and ... A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide …
Matched Description: … Afterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells. ... Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and ... A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Isoliquiritigenin
Isoliquiritigenin is a precursor to several flavonones in many plants.
Experimental
Matched Synonyms: … (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone …
Linifanib
Linifanib (ABT-869) is a small molecule vascular endothelial growth factor (VEGF) receptor-based kinase inhibitor that is designed to suppress tumor growth by preventing the formation of new blood vessels that supply the tumor with oxygen and nutrients and by inhibiting key angiogenic signaling pathways. Linifanib is intended for the treatment...
Investigational
Matched Synonyms: … 1-(4-(3-AMINO-1H-INDAZOL-4-YL)PHENYL)-3-(2-FLUORO-5-METHYLPHENYL)UREA ... N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl) urea ... UREA, N-(4-(3-AMINO-1H-INDAZOL-4-YL)PHENYL)-N'-(2-FLUORO-5-METHYLPHENYL)- …
Matched Iupac: … 3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea …
Matched Description: … Linifanib is intended for the treatment of hematologic malignancies and the solid tumors. ... nutrients and by inhibiting key angiogenic signaling pathways. ... suppress tumor growth by preventing the formation of new blood vessels that supply the tumor with oxygen and …
Matched Iupac: … 3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea …
Matched Description: … Linifanib is intended for the treatment of hematologic malignancies and the solid tumors. ... nutrients and by inhibiting key angiogenic signaling pathways. ... suppress tumor growth by preventing the formation of new blood vessels that supply the tumor with oxygen and …
Glatiramer
Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Synonyms: … Copolymer I (synthetic peptide) …
Matched Description: … is a first-line drug for patients with MS. ... , and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. ... [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … is a first-line drug for patients with MS. ... , and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. ... [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Estazolam
A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Approved
Illicit
Matched Synonyms: … 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine …
Matched Iupac: … 12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene …
Matched Description: … A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. …
Matched Categories: … Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives ... Hypnotics and Sedatives …
Matched Iupac: … 12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene …
Matched Description: … A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. …
Matched Categories: … Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives ... Hypnotics and Sedatives …
Phenylalanylmethylchloride
Experimental
Matched Synonyms: … (3S)-3-Amino-1-chloro-4-phenyl-2-butanone …
Propofol Hemisuccinate
Experimental
Matched Synonyms: … Butanedioic acid, 1-(2,6-bis(1-methylethyl)phenyl) ester …
Matched Iupac: … 4-[2,6-bis(propan-2-yl)phenoxy]-4-oxobutanoic acid …
Matched Iupac: … 4-[2,6-bis(propan-2-yl)phenoxy]-4-oxobutanoic acid …
Mefuparib
Investigational
Matched Synonyms: … 5-fluoro-2-(4-((methylamino)methyl)phenyl)-7-benzofurancarboxamide …
Matched Iupac: … 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide …
Matched Iupac: … 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide …
Erlotinib
Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Synonyms: … [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine …
Matched Description: … EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and ... of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion ... This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and ... of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion ... This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Fenfluramine
Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712,...
Approved
Illicit
Investigational
Withdrawn
Matched Synonyms: … 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane …
Matched Iupac: … ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine …
Matched Description: … It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity ... Concomitantly with these seizures, patients typically display delayed development and neurocognitive ... treatment of patients with Dravet syndrome and Lennox-Gastaut syndrome through the restricted FINTEPLA …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Iupac: … ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine …
Matched Description: … It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity ... Concomitantly with these seizures, patients typically display delayed development and neurocognitive ... treatment of patients with Dravet syndrome and Lennox-Gastaut syndrome through the restricted FINTEPLA …
Matched Categories: … Alimentary Tract and Metabolism …
methyl L-phenylalaninate
Experimental
Matched Synonyms: … Methyl 3-phenyl-L-alaninate …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Balsalazide
Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK.
The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt.
Balsalazide works by deliverying mesalazine...
Approved
Investigational
Matched Synonyms: … (E)-5-({p-[(2-carboxyethyl)carbamoyl]phenyl}azo)-2-salicylic acid ... (E)-5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxybenzoic acid ... 3-(2-{4-[(2-carboxyethyl)carbamoyl]phenyl}hydrazinylidene)-6-oxocyclohexa-1,4-diene-1-carboxylic acid …
Matched Iupac: … 5-[(1E)-2-{4-[(2-carboxyethyl)carbamoyl]phenyl}diazen-1-yl]-2-hydroxybenzoic acid …
Matched Description: … It is sold under the name "Colazal" in the US and "Colazide" in the UK. ... The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. …
Matched Categories: … Alimentary Tract and Metabolism ... Phenols …
Matched Iupac: … 5-[(1E)-2-{4-[(2-carboxyethyl)carbamoyl]phenyl}diazen-1-yl]-2-hydroxybenzoic acid …
Matched Description: … It is sold under the name "Colazal" in the US and "Colazide" in the UK. ... The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. …
Matched Categories: … Alimentary Tract and Metabolism ... Phenols …
Displaying drugs 601 - 625 of 1984 in total