Displaying drugs 6501 - 6525 of 8090 in total
Technetium Tc-99m epratuzumab
Technetium Tc-99m epratuzumab is under investigation in clinical trial NCT00003337 (Radiolabeled Monoclonal Antibody in the Detection and Staging of Patients With Non-Hodgkin's Lymphoma).
Investigational
Matched Description: … investigation in clinical trial NCT00003337 (Radiolabeled Monoclonal Antibody in the Detection and Staging of …
Brazikumab
Brazikumab is under investigation in clinical trial NCT03759288 (An Active and Placebo-controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease).
Investigational
Matched Description: … Brazikumab is under investigation in clinical trial NCT03759288 (An Active and Placebo-controlled Study of …
Imidazole-4-carboxylic acid
Imidazole-4-carboxylic acid is under investigation in clinical trial NCT00583895 (Safety and Efficacy Study of Imcooh Cream in Patients Suffering From Moderate Atopic Dermatitis).
Investigational
Matched Description: … Imidazole-4-carboxylic acid is under investigation in clinical trial NCT00583895 (Safety and Efficacy Study of …
IONIS-HBVRx
IONIS-HBVRx is under investigation in clinical trial NCT04544956 (A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B).
Investigational
Matched Description: … IONIS-HBVRx is under investigation in clinical trial NCT04544956 (A Mechanistic Study of GSK3228836 With …
Ieramilimab
Ieramilimab is under investigation in clinical trial NCT02460224 (Safety and Efficacy of LAG525 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.).
Investigational
Matched Description: … Ieramilimab is under investigation in clinical trial NCT02460224 (Safety and Efficacy of LAG525 Single …
ALM201
ALM201 is an anti-angiogenic synthetic peptide identified from the endogenous human protein, FKBPL. It is being investigated in the treatment of various cancers.
Investigational
Matched Description: … It is being investigated in the treatment of various cancers.[A254556] …
ATX-F8-117
ATX-F8-117 is an investigational peptide derived from Factor VIII. Developed by Apitope, it is being investigated for the treatment of hemophilia A.
Investigational
Matched Description: … Developed by Apitope, it is being investigated for the treatment of hemophilia A.[L46163] …
NVL-655
NVL-655 is an orally bioavailable, brain-penetrant anaplastic lymphoma kinase (ALK) inhibitor inhibitor being investigated for the treatment of non-small cell lung cancer.
Investigational
Matched Description: … brain-penetrant anaplastic lymphoma kinase (ALK) inhibitor inhibitor being investigated for the treatment of …
inBreath airway transplant system
inBreath airway transplant system composes of a scaffold seeded with autologous bone marrow cells and incubated in the bioreactor for two days prior to implant.
Investigational
Matched Description: … inBreath airway transplant system composes of a scaffold seeded with autologous bone marrow cells and …
VPM1002
The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. ... The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis ... BCG Prague as it has a better safety profile than some other BCG versions due to the lack of the RD2 …
Putrescine
Putrescine is a toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. Putrescine is a solid. This compound belongs to the polyamines. These are compounds containing more than one amine group. Known drug targets of putrescine include putrescine-binding periplasmic protein, ornithine decarboxylase, and S-adenosylmethionine decarboxylase proenzyme.
Experimental
Matched Description: … Putrescine is a toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine ... Known drug targets of putrescine include putrescine-binding periplasmic protein, ornithine decarboxylase …
MK-0354
MK-0354, is an orally administered drug candidate under development by Merck for the treatment of atherosclerosis and related disorders. It targets G protein-coupled receptor, or GPCR, that have the potential to regulate plasma lipid profiles, including HDL, or the good cholesterol, similar to the therapeutic action of niacin.
Investigational
Matched Description: … MK-0354, is an orally administered drug candidate under development by Merck for the treatment of atherosclerosis ... regulate plasma lipid profiles, including HDL, or the good cholesterol, similar to the therapeutic action of …
PX-478
PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical trial in patients with advanced metastatic cancer and lymphoma. PX-478 was effective in models of both non-small cell lung cancer
and small cell lung cancer that express HIF-1 alpha.
Investigational
Matched Description: … PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical ... PX-478 was effective in models of both non-small cell lung cancer
and small cell lung cancer that express …
3,4-Methylenedioxy-N-isopropylamphetamine
MDI-P has demonstrated potent anti-HIV activity. MDI-P has been shown to be effective in killing HIV in cell culture. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). MDI-P is also a potential therapeutic agent for the treatment of the symptoms of cystic fibrosis ("CF").
Investigational
Matched Description: … MDI-P is also a potential therapeutic agent for the treatment of the symptoms of cystic fibrosis ("CF …
Quaternium-18
Quaternium-18 is a mixture of quaternary ammonium chloride salts. Quaternium-18 Hectorite and Bentonite are the reaction products of Quaternium-18 with clays. These compounds are poorly absorbed through the skin. Acute oral and percutaneous toxicity tests in animals indicate that they exhibit little or no systemic toxic effects.
Experimental
Matched Description: … Quaternium-18 is a mixture of quaternary ammonium chloride salts. ... Quaternium-18 Hectorite and Bentonite are the reaction products of Quaternium-18 with clays. …
Alfaxalone
Alfaxalone, also known as alphaxalone or alphaxolone, is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin.
Vet approved
Matched Description: … Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin. …
Phosphorus P-32
Phosphorus P-32 is a radioactive isotope of phosphorus with beta particle-emitting radiocytotoxic activity. Emitted by phosphorus P32, beta particles directly damage cellular DNA and, by ionizing intracellular water to produce several types of cytotoxic free radicals and superoxides, indirectly damage intracellular biological macromolecules, resulting in tumor cell death.
Experimental
Matched Description: … Phosphorus P-32 is a radioactive isotope of phosphorus with beta particle-emitting radiocytotoxic activity ... particles directly damage cellular DNA and, by ionizing intracellular water to produce several types of …
Avasopasem manganese
Avasopasem manganese, also known as GC4419, is a highly-selective small molecule mimetic of superoxide dismutase (SOD) being investigated for the reduction of radiation-induced severe oral mucositis.[L27246, L27256] This drug has potential application for radiation-induced esophagitis and oral mucositis, in addition to being currently tested against COVID-19.
Investigational
Matched Description: … Avasopasem manganese, also known as GC4419, is a highly-selective small molecule mimetic of superoxide ... dismutase (SOD) being investigated for the reduction of radiation-induced severe oral mucositis. …
Calusterone
A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada.
Experimental
Illicit
Dendritic cells vaccine
The recombinant chimeric DC vaccine is a subunit-based vaccine candidate investigated for safety and effectiveness against SARS-CoV-2-induced pneumonia. With a better safety profile than inactivated and live-attenuated virus and virus-vector vaccines, the recombinant chimeric DC vaccine reduces the risk of virulence recovery, pre-existing anti-vector immunity, and incomplete viral inactivation.
As...
Investigational
Matched Description: … live-attenuated virus and virus-vector vaccines, the recombinant chimeric DC vaccine reduces the risk of ... As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
AG0301-COVID19
AG0301-COVID19 is a vaccine candidate developed by AnGes Inc. and Osaka University. The candidate is a plasmid DNA vaccine developed using an intradermal gene transfer method targeting the SARS-CoV-2 spike protein. The gene transfer method increases the efficiency of gene expression and antibody production capability, garnering a more efficient DNA...
Investigational
Matched Description: … The gene transfer method increases the efficiency of gene expression and antibody production capability ... On September 8, 2020 AnGes announced collaboration with Brickell Biotech, Inc. following completion of …
Antipain
Antipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes. Early studies investigated the potential for antipain to alter DNA damage and chromosomal aberrations in irradiated cells or those treated with chemical mutagens such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).[A214484, A214487]
Antipain was used in 2010 to obtain a crystal...
Experimental
Matched Description: … Antipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes ... [A214484, A214487]
Antipain was used in 2010 to obtain a crystal structure of the _Leishmania major ... [A214490] The binding of antipain to OPB has been used in molecular dynamic studies to identify other …
XL820
XL820 is investigated for use/treatment in solid tumors. XL820 is a solid. The proteins that XL820 inhibit include platelet-derived growth factor receptor beta (PDGFR), mast/stem cell growth factor receptor KIT, vascular endothelial growth factor receptor 2, and platelet-derived growth factor receptor alpha, clinically validated targets implicated in a variety of...
Investigational
Matched Description: … XL820 exhibits dose-dependent growth inhibition in models of breast carcinoma, gliomas and leukemia. ... platelet-derived growth factor receptor alpha, clinically validated targets implicated in a variety of …
AMG-131
AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131...
Investigational
Matched Description: … T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor ... T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos …
Lactobacillus plantarum
Lactobacillus plantarum is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and metabolic processes, while exhibiting an antagonistic activity against pathogenic...
Investigational
Matched Description: … *Lactobacillus plantarum* is a member of Lactobacillus, or lactic acid bacteria, that it is widely used ... It is considered to be one of versatile species that carry out fermentative and metabolic processes, …
Displaying drugs 6501 - 6525 of 8090 in total