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Displaying drugs 651 - 675 of 10193 in total
Galcanezumab
Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Products: … EMGALİTY 120 MG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 2 ADET ... EMGALİTY 120 MG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 1 ADET …
Oteracil
Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy. Approved by the European Medicines Agency (EMA) in March 2011, Oteracil is available in combination with DB09257 and DB09256 within the commercially available product "Teysuno". The main active ingredient in Teysuno is DB09256,...
Approved
Matched Synonyms: … 5-azaorotic acid …
Matched Iupac: … 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid …
Matched Description: … The main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic ... Oteracil's main role within Teysuno is to reduce the activity of 5-FU within normal gastrointestinal ... By mimicking a class of compounds called "pyrimidines" that are essential components of RNA and DNA, 5- …
Matched Salts cas: … 2207-75-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid …
Matched Description: … The main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic ... Oteracil's main role within Teysuno is to reduce the activity of 5-FU within normal gastrointestinal ... By mimicking a class of compounds called "pyrimidines" that are essential components of RNA and DNA, 5- …
Matched Salts cas: … 2207-75-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Pefloxacin
A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Iupac: … 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Flurazepam
A benzodiazepine derivative used mainly as a hypnotic.
Approved
Illicit
Investigational
Matched Iupac: … 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Salts cas: … 36105-20-1 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Salts cas: … 36105-20-1 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Pizotifen
Pizotifen belongs to the class of antamines and is related to cyproheptadine. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties . Some patients receiving pizotifen...
Approved
Matched Iupac: … 1-methyl-4-{6-thiatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene}piperidine …
Matched Salts cas: … 5189-11-7 …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Adrenergic alpha-1 Receptor Antagonists ... Serotonin 5-HT1 Receptor Antagonists ... Serotonin 5-HT2 Receptor Antagonists ... Serotonin 5-HT2A Receptor Antagonists …
Matched Salts cas: … 5189-11-7 …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Adrenergic alpha-1 Receptor Antagonists ... Serotonin 5-HT1 Receptor Antagonists ... Serotonin 5-HT2 Receptor Antagonists ... Serotonin 5-HT2A Receptor Antagonists …
Oprelvekin
Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid...
Approved
Investigational
Viltolarsen
Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Human papillomavirus type 11 L1 capsid protein antigen
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Matched Mixtures name: … GARDASİL 9 IM ENJEKSİYONLUK SÜSPANSİYON, 1 ADET ŞIRINGA+2 ADET İĞNE …
Natamycin
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
Approved
Matched Iupac: … 7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2- …
Matched Products: … NATACYN 5% STERILE OPHTHALMIC SUSPENSION ... NATACYN ® 5% SUSPENSION OFTALMICA ESTERIL ... NATACYN (NATAMYCIN 5%) OPHTHALMIC SUSPENSION …
Matched Products: … NATACYN 5% STERILE OPHTHALMIC SUSPENSION ... NATACYN ® 5% SUSPENSION OFTALMICA ESTERIL ... NATACYN (NATAMYCIN 5%) OPHTHALMIC SUSPENSION …
Didecyldimethylammonium
Approved
Experimental
Matched Salts cas: … 7173-51-5 …
Matched Mixtures name: … Pure Formula 1 advanced wipes 50wipes 01 ... Pure Formula 1 advanced wipes 100wipes 01 …
Matched Mixtures name: … Pure Formula 1 advanced wipes 50wipes 01 ... Pure Formula 1 advanced wipes 100wipes 01 …
Simeprevir
Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United...
Approved
Matched Iupac: … (1R,4R,6R,7Z,15R,17R)-N-(cyclopropanesulfonyl)-17-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol ... -2-yl]quinolin-4-yl}oxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0^{4,6}]octadec-7-ene-4-carboxamide …
Matched Description: … or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4. ... Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 …
Matched Description: … or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4. ... Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 …
Methyltestosterone
A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US.
Approved
Matched Iupac: … ,11aH-cyclopenta[a]phenanthren-7-one ... (1S,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H …
Aripiprazole lauroxil
Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of aripiprazole, which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors .
Affecting about 1% of the...
Approved
Investigational
Matched Iupac: … (7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)methyl dodecanoate …
Matched Description: … as an antagonist at the 5-HT2A receptors [A34289]. ... Affecting about 1% of the adult population in the United States and approximately 26 million people worldwide ... It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Adrenergic alpha-1 Receptor Antagonists ... Heterocyclic Compounds, 1-Ring ... Serotonin 5-HT2 Receptor Antagonists ... Serotonin 5-HT2A Receptor Antagonists …
Matched Description: … as an antagonist at the 5-HT2A receptors [A34289]. ... Affecting about 1% of the adult population in the United States and approximately 26 million people worldwide ... It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Adrenergic alpha-1 Receptor Antagonists ... Heterocyclic Compounds, 1-Ring ... Serotonin 5-HT2 Receptor Antagonists ... Serotonin 5-HT2A Receptor Antagonists …
Flutamide
An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Approved
Investigational
Matched Synonyms: … α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide …
Matched Iupac: … 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide …
Matched Iupac: … 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide …
Rifaximin
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of...
Approved
Investigational
Matched Products: … RIFAXIMINA 2% ... RIFAX 2% - POLVO PARA RECONSTITUIR SUSPENSIONORAL …
Nirsevimab
Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants. It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry...
Approved
Investigational
Matched Synonyms: … heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4*01 (90.1%)) (8.8.19) (1-126) -homo ... human respiratory syncytial virus fusion glycoprotein f0 (protein f))human monoclonal antibody.gamma.1 ... Immunoglobulin g1, anti-(human respiratory syncytial virus fusion protein)(human monoclonal med18897 .gamma.1- …
Octocrylene
Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin...
Approved
Investigational
Matched Iupac: … 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate …
Matched Mixtures name: … Gold Bond Ultimate 5-in-1 Face ... 2 in 1 Sunscreen and Gradual Self-Tanner ... CareOne 7-in-1 Anti-Aging Vitamin …
Matched Mixtures name: … Gold Bond Ultimate 5-in-1 Face ... 2 in 1 Sunscreen and Gradual Self-Tanner ... CareOne 7-in-1 Anti-Aging Vitamin …
Tolazamide
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Approved
Investigational
Matched Synonyms: … 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea ... 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea …
Matched Iupac: … 1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea …
Matched Iupac: … 1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea …
Histrelin
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Synonyms: … 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide ... 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Nτ-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide …
Matched Iupac: … (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-benzyl-1H-imidazol-4-yl)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)- ... 3-(1H-imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido ... ]propanamido]-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido]-5-carbamimidamidopentanoyl ... ]-N-ethylpyrrolidine-2-carboxamide; bis(acetic acid) …
Matched Iupac: … (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-benzyl-1H-imidazol-4-yl)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)- ... 3-(1H-imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido ... ]propanamido]-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido]-5-carbamimidamidopentanoyl ... ]-N-ethylpyrrolidine-2-carboxamide; bis(acetic acid) …
Grepafloxacin
Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Approved
Investigational
Withdrawn
Matched Iupac: … 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Gliquidone
Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
Approved
Investigational
Matched Iupac: … 3-cyclohexyl-1-{4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzenesulfonyl …
Matched Description: … Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. …
Matched Description: … Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. …
Relebactam
Relebactam is a diazabicyclooctane beta-lactamase inhibitor, similar in structure to avibactam.[A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge. It is currently available in a combination product which includes imipenem and cilastatin to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated...
Approved
Investigational
Matched Iupac: … [(1R,2S,5R)-7-oxo-2-[(piperidin-4-yl)carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl]oxidanesulfonic acid …
Matched Categories: … MATE 1 Substrates ... MATE 2 Substrates ... Heterocyclic Compounds, 2-Ring …
Matched Categories: … MATE 1 Substrates ... MATE 2 Substrates ... Heterocyclic Compounds, 2-Ring …
Parthenolide
Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis.
Approved
Investigational
Matched Iupac: … (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one …
Bifonazole
Bifonazole is an azole antifungal drug.
Approved
Investigational
Matched Synonyms: … (+-)-1-(p,alpha-Diphenylbenzyl)imidazole ... 1-(p,alpha-Diphenylbenzyl)imidazole ... 1-(alpha-(4-Biphenylyl)benzyl)imidazole …
Matched Iupac: … 1-({[1,1'-biphenyl]-4-yl}(phenyl)methyl)-1H-imidazole …
Matched Mixtures name: … CANESTEN ULTRA UÑAS 1% …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … ANTIZOX® 1% CREMA ... MYCOSPOR POLVO 1 G. ... MYCOSPOR POLVO AL 1% …
Matched Iupac: … 1-({[1,1'-biphenyl]-4-yl}(phenyl)methyl)-1H-imidazole …
Matched Mixtures name: … CANESTEN ULTRA UÑAS 1% …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … ANTIZOX® 1% CREMA ... MYCOSPOR POLVO 1 G. ... MYCOSPOR POLVO AL 1% …
Methyl aminolevulinate
Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.
Approved
Investigational
Matched Synonyms: … methyl 5-aminolevulinate ... 5-aminolevulinic acid methyl ester …
Matched Iupac: … methyl 5-amino-4-oxopentanoate …
Matched Iupac: … methyl 5-amino-4-oxopentanoate …
Displaying drugs 651 - 675 of 10193 in total