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Displaying drugs 726 - 750 of 1045 in total

Bosentan

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Description: … blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … PROART FILM COATED TABLETS 125MG ... DIAMOND 125 MG FILM TABLET, 112 ADET ... CLOKSAR 125 MG FILM TABLET, 56 TABLET …

Oxcarbazepine

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate...
Approved
Matched Description: … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … OXCARIL 150 MG FILM TABLET, 50 ADET ... OXCARIL 300 MG FILM TABLET, 50 ADET ... OXCARIL 600 MG FILM TABLET, 50 ADET …

Olmesartan

Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, valsartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Description: … , particularly in patients who are unable to tolerate ACE inhibitors. ... aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. ... and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of …
Matched Mixtures name: … Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil …
Matched Categories: … Angiotensin II Antagonists and Calcium Channel Blockers ... olmesartan medoxomil and diuretics ... olmesartan medoxomil and amlodipine ... Angiotensin II receptor blockers (ARBs) and diuretics ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Matched Products: … OMETAN 5 MG FILM TABLET,FILM TABLET, 28 ADET ... OMETAN 5 MG FILM TABLET,FILM TABLET, 84 ADET ... OMETAN 10 MG FILM TABLET,FILM TABLET, 28 ADET …

Dipotassium phosphate

Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Approved
Matched Synonyms: … Phosphoric acid, dipotassium salt ... Phosphoric acid, potassium salt (1:2) …
Matched Description: … Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive ... as a source of phosphorus and potassium as well as a buffering agent. …
Matched Mixtures name: … Ionosol B and Dextrose …
Matched Categories: … Potassium Salt ... Phosphate salts …

Dapoxetine

Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation...
Investigational
Matched Mixtures name: … DAPOXIL 30/50 MG FILM KAPLI TABLET,18 FILM KAPLI TABLET ... DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET ... DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLET …
Matched Categories: … Genito Urinary System and Sex Hormones …
Matched Products: … DAPIGRA 30 MG FILM TABLET ,3 FILM TABLET ... DAPIGRA 30 MG FILM TABLET ,6 FILM TABLET ... DAPIGRA 60 MG FILM TABLET ,3 FILM TABLET …

Palbociclib

Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery that identified the cyclin-dependent kinases as...
Approved
Investigational
Matched Description: … electronic health records demonstrating safety and clinical efficacy. ... inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and ... on March 2015 for the treatment of HR-positive, HER2-negative advanced or metastatic breast cancer and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … IBRANCE FILM COATED TABLET 75MG ... IBRANCE FILM COATED TABLET 100MG ... IBRANCE FILM COATED TABLET 125MG …

Tadalafil

Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors...
Approved
Investigational
Matched Description: … that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and ... [L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. ... In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and …
Matched Mixtures name: … TADA PLUS 30/20 MG FILM KAPLI TABLET ,4 ADET ... TADA PLUS 30/20 MG FILM KAPLI TABLET ,8 ADET …
Matched Categories: … tamsulosin and tadalafil ... macitentan and tadalafil ... ambrisentan and tadalafil ... finasteride and tadalafil ... Genito Urinary System and Sex Hormones …
Matched Products: … MYESED 10MG FILM KAPLI TABLET ,2 FILM TABLET ... MYESED 10MG FILM KAPLI TABLET ,4 FILM TABLET ... MYESED 10MG FILM KAPLI TABLET ,8 FILM TABLET …

Trametinib

Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and ... [A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission ... currently approved to treat a variety of cancers with BRAF mutations, such as non-small cell lung cancer and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … MEKINIST FILM-COATED TABLETS 2MG ... MEKINIST FILM-COATED TABLETS 0.5MG ... MEKINIST 2 MG FILM KAPLI TABLET ,7 TABLET …

Brexpiprazole

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Description: … Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called ... It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. ... It also displays stronger antagonism at the 5-HT1A and 5-HT2A receptors. …
Matched Products: … Rexulti 1mg film-coated tablets ... Rexulti 4mg film-coated tablets ... Rexulti 3mg film-coated tablets …

Atorvastatin

Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Description: … for people who are at moderate to high risk of developing cardiovascular disease. ... [A181087, A181406] Some evidence has shown that even for low-risk individuals (with <10% risk of a major ... event occurring within five years) statin use leads to a 20%-22% relative reduction in the number of major …
Matched Mixtures name: … Amlodipine Besylate and Atorvastatin Calcium ... Amlodipine and atorvastatin ... Amlodipine and atorvastatin …
Matched Categories: … atorvastatin and ezetimibe ... atorvastatin and amlodipine ... atorvastatin and perindopril ... atorvastatin, amlodipine and ramipril ... atorvastatin and acetylsalicylic acid …
Matched Products: … Zarator 40mg Film Coated Tablet ... Zarator 80mg Film Coated Tablet ... Zarator 10mg Film Coated Tablet …

Apixaban

Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28,...
Approved
Matched Description: … Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa ... , as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … Eliquis 5mg film-coated tablets ... Eliquis 2.5mg film-coated tablets ... Apaclot 5 mg Film Kaplı Tablet, 60 ADET …

Entecavir

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents...
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) in March 2005. ... Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the ... manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and …
Matched Categories: … Nucleosides and Nucleotides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Matched Products: … ENTEFIL 1 MG FILM TABLET ,FILM TABLET, 30 ADET ... ENTEFIL 0.5 MG FILM TABLET ,FILM TABLET, 30 ADET ... Hebecavir Film Coated Tablet 0.5mg …

Pitavastatin

Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Description: … stroke, has become a leading cause of death in high-income countries and a major cause of morbidity ... lipid levels and ultimately reduce the risk of cardiovascular disease. ... inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and …
Matched Products: … Livalo Film-coated Tablets 2mg ... Livalo Film-coated Tablets 4mg ... LIVALO FILM-COATED TABLETS 4MG …

Moxifloxacin

Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Approved
Investigational
Matched Description: … Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride …
Matched Products: … MOXICUM 400 MG FILM TABLET ,5 FILM TABLET ... MOXICUM 400 MG FILM TABLET ,FILM TABLET, 10 ADET ... MOXICUM 400 MG FILM TABLET ,FILM TABLET, 7 ADET …

Erlotinib

Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Description: … EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and ... , which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and ... This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … TARCEVA FILM-COATED TABLET 25 MG ... Tarceva Film Coated Tablet 25mg ... TARCEVA FILM-COATED TABLET 100 MG …

Zinc monoethylfumarate

Experimental
Matched Synonyms: … Monoethyl fumarate zinc salt …

Sildenafil

In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to...
Approved
Investigational
Matched Description: … it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614 ... The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth ... and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows …
Matched Mixtures name: … DAPOXIL 30/50 MG FILM KAPLI TABLET,18 FILM KAPLI TABLET ... DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET ... DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLET …
Matched Products: … VULGAR 25 MG FILM TABLET, 4 FILM TABLET ... VULGAR 50 MG FILM TABLET, 4 FILM TABLET ... VULGAR 100 MG FILM TABLET, 4 FILM TABLET …

Perampanel

Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning...
Approved
Matched Description: … It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for ... The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and …
Matched Products: … Fycompa 8mg Film-coated Tablets ... Fycompa 2mg Film-coated Tablets ... Fycompa 6mg Film-coated Tablets …

Cefpodoxime

Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Approved
Vet approved
Matched Description: … is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and ... which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. ... Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug …
Matched Mixtures name: … TEXEF PLUS 100/62.5 MG FİLM KAPLI TABLET, 20 ADET ... TEXEF PLUS 200/125 MG FILM KAPLI TABLET, 20 ADET …
Matched Products: … DUCHESS 100 MG FILM TABLET, 20 ADET ... DOKSELIN 200 MG FILM TABLET, 14 ADET ... DUCHESS 200 MG FILM TABLET, 14 ADET …

Irbesartan

Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy. Unlike angiotensin converting enzyme inhibitors, ARBs are not associated...
Approved
Investigational
Matched Mixtures name: … Irbesartan and Hydrochlorothiazide ... Irbesartan and Hydrochlorothiazide ... Irbesartan and Hydrochlorothiazide …
Matched Categories: … irbesartan and diuretics ... irbesartan and amlodipine ... Angiotensin II receptor blockers (ARBs) and diuretics ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers ... irbesartan, amlodipine and hydrochlorothiazide …
Matched Products: … APROVEL 300MG FILM-COATED TABLET ... Irstran Film Coated Tablet 150mg ... Irstran Film Coated Tablet 300mg …

Solifenacin

Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004.
Approved
Matched Description: … muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and …
Matched Categories: … tamsulosin and solifenacin ... Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …
Matched Products: … VESICARE 5 MG FILM-COATED TABLET ... VESICARE 10 MG FILM-COATED TABLET ... BLADITON FILM COATED TABLETS 5MG …

Pazopanib

Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Approved
Matched Description: … It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … VOTRIENT FILM-COATED TABLET 200MG ... VOTRIENT FILM-COATED TABLET 400MG ... VOTRIENT 200 MG FİLM KAPLI TABLET, 30 ADET …

Abiraterone

Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 2011, respectively. It is used to treat metastatic...
Approved
Matched Description: … ] and September 2011,[A260880] respectively. ... Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17 ... ), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... niraparib and abiraterone ... abiraterone and prednisolone ... Hormone Antagonists and Related Agents ... Metabolic Side Effects of Drugs and Substances …
Matched Products: … ZYTIGA 500mg Film-Coated Tablet ... ZYTIGA FILM-COATED TABLET 500MG ... ZYTIGA 500 MG (FILM-COATED TABLETS) …

Venetoclax

Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Description: … Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic ... chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … VENCLEXTA FILM-COATED TABLET 10MG ... VENCLEXTA FILM-COATED TABLET 50MG ... VENCLEXTA FILM-COATED TABLET 100MG …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Description: … [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. ... The effect of this drug has no homology in human host cells, which gives it excellent tolerability and …
Matched Mixtures name: … TRIUMEQ 50 MG/600 MG/300 MG FILM KAPLI TABLET,90 FILM KAPLI TABLET ... TRIUMEQ 50 MG/600 MG/300 MG FILM KAPLI TABLET,FILM KAPLI TABLET, 30 ADET ... TRIUMEQ FILM COATED TABLET 50mg/600mg/300mg …
Matched Categories: … lamivudine and dolutegravir ... dolutegravir and rilpivirine ... lamivudine, abacavir and dolutegravir ... lamivudine, tenofovir disoproxil and dolutegravir …
Matched Products: … Tivicay 50mg Film-Coated Tablets ... TIVICAY FILM-COATED TABLET 25MG ... TIVICAY FILM-COATED TABLET 10MG …
Displaying drugs 726 - 750 of 1045 in total