Displaying drugs 726 - 750 of 14568 in total
Pamidronic acid
Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to neridronic acid and alendronic acid. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as ibandronic acid, zoledronic acid, minodronic acid, and risedronic acid are becoming...
Approved
Matched Description: … Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and ... third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and …
Matched Categories: … Drugs Affecting Bone Structure and Mineralization …
Matched Categories: … Drugs Affecting Bone Structure and Mineralization …
Meprobamate
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated)....
Approved
Illicit
Matched Description: … A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses ... It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia …
Matched Categories: … Hypnotics and Sedatives …
Matched Categories: … Hypnotics and Sedatives …
Zoledronic acid
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid...
Approved
Matched Description: … of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. ... third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and ... [A203111] Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia …
Matched Categories: … Drugs Affecting Bone Structure and Mineralization ... zoledronic acid, calcium and colecalciferol, sequential …
Matched Categories: … Drugs Affecting Bone Structure and Mineralization ... zoledronic acid, calcium and colecalciferol, sequential …
Chlormerodrin
Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Approved
Withdrawn
Matched Description: … The radiolabeled form has been used as a diagnostic and research tool. ... It is no longer used and has been replaced with new classes of diuretic drugs. …
Clofarabine
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic...
Approved
Investigational
Matched Description: … It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. ... Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Deferoxamine
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Approved
Investigational
Matched Description: … It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. …
Didanosine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral...
Approved
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Zalcitabine
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Busulfan
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Capecitabine
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Approved
Investigational
Matched Description: … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and ... enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and …
Matched Categories: … Fluorouracil and prodrugs ... Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Fluorouracil and prodrugs ... Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Ambenonium
Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Approved
Pivmecillinam
Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Approved
Matched Description: … It is active against gram-negative organisms and used as for amdinocillin. [PubChem] …
Taurine
Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and...
Approved
Nutraceutical
Matched Description: … can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and ... [L1058] The supplements containing taurine were FDA approved by 1984 and they are hypertonic injections …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Regadenoson
Regadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial perfusion imagining. Manufactured by Astellas and FDA approved April 10, 2008.
Approved
Investigational
Matched Description: … Manufactured by Astellas and FDA approved April 10, 2008. ... Regadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial …
Safinamide
Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Approved
Investigational
Matched Description: … It was approved in Europe in February 2015, and in the United States on March 21, 2017. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Triclofos
Approved
Withdrawn
Matched Salts name: … Triclofos sodium …
Matched Categories: … Hypnotics and Sedatives …
Matched Categories: … Hypnotics and Sedatives …
Lanthanum carbonate
Lanthanum carbonate is a phosphate binder marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to...
Approved
Matched Description: … It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse ... phosphate levels, primarily in patients with chronic kidney disease, by binding to dietary phosphate and …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Mebutamate
Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a sedative. Side effects include dizziness and headaches.
Approved
Matched Description: … Side effects include dizziness and headaches. ... Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects …
Treosulfan
Treosulfan is under investigation in Allogeneic Haematopoietic Stem Cell Transplantation. Treosulfan has been investigated for the treatment of Lymphoblastic Leukemia, Acute, Childhood.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Daprodustat
Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … HIF1α and HIF2α and the induces erythropoiesis. ... As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular ... [A254157] On October 2022, the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Mannitol busulfan
Mm has been used in trials studying the treatment of Cocaine Dependence and Diabetes Mellitus, Type 2.
Approved
Investigational
Matched Description: … Mm has been used in trials studying the treatment of Cocaine Dependence and Diabetes Mellitus, Type 2 …
Relebactam
Relebactam is a diazabicyclooctane beta-lactamase inhibitor, similar in structure to avibactam.[A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge. It is currently available in a combination product which includes imipenem and cilastatin to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated...
Approved
Investigational
Matched Description: … [A181207] It is currently available in a combination product which includes [imipenem] and [cilastatin ... ] to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated intra-abdominal ... [label] It is considered to be a last-line treatment option and gained FDA approval as part of the combination …
Matched Salts name: … Relebactam sodium …
Matched Categories: … imipenem, cilastatin and relebactam …
Matched Salts name: … Relebactam sodium …
Matched Categories: … imipenem, cilastatin and relebactam …
Remdesivir
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase...
Approved
Investigational
Matched Description: … the related SARS-CoV and MERS-CoV,[A222398] and has been investigated in multiple COVID-19 clinical ... disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and ... , A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action,[A222398] and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Nucleosides and Nucleotides ... Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Nucleosides and Nucleotides ... Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Givosiran
Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic...
Approved
Investigational
Matched Description: … [L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States ... genetic disorder in which the overproduction of toxic heme intermediates leads to neuro-, nephro-, and ... non-therapeutic measures (e.g. trigger avoidance), intravenous [hemin] for the treatment of attacks, and …
Matched Salts name: … Givosiran sodium …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Matched Salts name: … Givosiran sodium …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Phenformin
A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Approved
Investigational
Withdrawn
Matched Description: … A biguanide hypoglycemic agent with actions and uses similar to those of metformin. …
Matched Categories: … Alimentary Tract and Metabolism ... phenformin and sulfonylureas …
Matched Categories: … Alimentary Tract and Metabolism ... phenformin and sulfonylureas …
Displaying drugs 726 - 750 of 14568 in total