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Displaying drugs 951 - 975 of 14659 in total
Antilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
Approved
Investigational
Matched Description: … Antilipemic agent that lowers cholesterol and triglycerides. ... It decreases low density lipoproteins and increases high density lipoproteins. …
Matched Categories: … Benzamides and benzamide derivatives …
Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Description: … promising safety and tolerability. ... treatment of migraine and the treatment of episodic cluster headache. ... Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … and clomipramine. ... than secondary amine TCAs, such as nortriptyline and desipramine. ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Description: … It was superseded by [pioglitazone] and [rosiglitazone]. …
Matched Categories: … Alimentary Tract and Metabolism …
Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera Chondrodendron and Strychnos....
Approved
Matched Description: … number of plant-derived alkaloids, including [morphine] and [papaverine]. ... Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid ... darts, which were typically derived from plants of the genera _Chondrodendron_ and _Strychnos_. …
Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by...
Approved
Investigational
Matched Description: … infarction (non-reversible defects); and 2) evaluating myocardial function and developing information ... intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and ... indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and
Matched Categories: … Indicators and Reagents …
Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen...
Approved
Matched Description: … Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various ... However the clinical significance and mechanism of action of sodium sulfide and replication of results ... been investigated in models of inflammation and oxidative stress. …
Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives developed by FoldRX. Tafamidis is structurally similar to diflusinal. Tafamidis was granted an EMA market authorisation on 16 November 2011 and FDA approval on 3 May 2019.
Approved
Investigational
Matched Description: … Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives[A27206] developed by FoldRX. ... [A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Micronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names Sagamicin and Luxomicina.
Approved
Matched Description: … Sagamicin and Luxomicina. ... Micronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names …
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the...
Approved
Matched Description: … The difference in density between the gas-filled bubbles and the blood around them creates an increased ... When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Approved
Investigational
A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Description: … A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Approved
Matched Description: … peripheral origin, and as an adjuvant in the therapy of epilepsy. ... Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 ... effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and
Matched Categories: … Calcium-Regulating Hormones and Agents …
Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Description: … [L43277] Niraparib is selective towards PARP-1 and PARP-2. ... [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health …
Matched Categories: … niraparib and abiraterone ... Antineoplastic and Immunomodulating Agents …
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the...
Approved
Investigational
Matched Description: … Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors ... [A181180] It is used in adults and has been shown to be comparable in efficacy to other drugs such as ... promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and
Matched Categories: … Serotonin antagonist and reuptake inhibitors (SARIs) …
Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib),...
Approved
Investigational
Matched Description: … Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation...
Approved
Investigational
Matched Description: … [clotrimazole], due to its broad spectrum and good absorption. ... Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal ... Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations. …
Matched Categories: … Sex Hormones and Insulins ... Imidazole and Triazole Derivatives ... Gynecological Antiinfectives and Antiseptics ... Metabolic Side Effects of Drugs and Substances …
Bacillus calmette-guerin substrain connaught live antigen is intravesically administered for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). The solution contains live, attenuated strain of Mycobacterium bovis....
Approved
Investigational
Matched Description: … It is prepared from the Connaught strain of Bacillus Calmette and GuĂ©rin. ... recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). ... prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or …
Secretin porcine stimulates pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma.
Approved
Matched Description: … dysfunction and the diagnosis of gastrinoma. ... Secretin porcine stimulates pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine …
Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy....
Approved
Investigational
Matched Description: … is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that...
Approved
Investigational
Matched Description: … Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain ... Imiquimod does not cure warts, and new warts may appear during treatment. ... Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. …
Matched Categories: … Skin and Mucous Membrane Agents …
Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor...
Approved
Investigational
Matched Description: … [L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related ... of medications referred to as "gepants", have been investigated for migraines, but only ubrogepant and ... [A189195] They appear to be better tolerated, do not contribute to medication overuse headaches, and
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being...
Approved
Illicit
Matched Description: … benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and ... , however, like most benzodiazepines, clonazepam use has also been associated with recreational use and ... [FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …
Approved
Experimental
Matched Categories: … Diet, Food, and Nutrition …
Barium sulfate is an inorganic compound with the chemical formula BaSO4 . Barium sulfate occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield . This drug is used as a contrast agent in...
Approved
Matched Description: … It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation ... Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent ... Therapeutic advantages of barium sulfate in diagnostic procedures include both its low water solubility and
Displaying drugs 951 - 975 of 14659 in total