Displaying drugs 10101 - 10125 of 12433 in total
Echinacoside
Echinacoside is a phenylethanoid glycoside isolated from Echinacea angustifolia in 1950, and currently being investigated for the treatment of Parkinson's, Alzheimer's, atherosclerosis, osteoporosis, acute colitis, wound treatment, and hepatitis. Echinacoside has demonstrated inhibition of apoptosis in neural cell lines, demonstrating potential for use in the treatment of neurological conditions.
Experimental
Matched Description: … for use in the treatment of neurological conditions. ... isolated from _Echinacea angustifolia_ in 1950, and currently being investigated for the treatment of ... [A184577] Echinacoside has demonstrated inhibition of apoptosis in neural cell lines, demonstrating potential …
2-Methoxyestradiol
2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Investigational
Matched Description: … 2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need …
Trabodenoson
Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG).
Investigational
Matched Description: … Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary …
Aviptadil
Experimental
Matched Iupac: … carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid …
Vasoactive intestinal peptide
Investigational
Matched Iupac: … carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid …
19-norandrostenedione
19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency.
In the...
Experimental
Illicit
GMX1777
GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic activity. In vivo, apoptosis inducer GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa...
Investigational
Matched Description: … GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic ... In vivo, apoptosis inducer GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a ... nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. …
Etizolam
Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983...
Experimental
Taspoglutide
Taspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. In September 2010 Roche halted Phase III clinical trials due to incidences of serious hypersensitivity reactions and gastrointestinal side effects. As of May 2013 no...
Investigational
Matched Iupac: … }methyl)carbamoyl]-4-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-2-methylpropanamido}butanoic acid …
Matched Description: … As of May 2013 no new trials had been registered. ... pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of ... In September 2010 Roche halted Phase III clinical trials due to incidences of serious hypersensitivity …
Matched Description: … As of May 2013 no new trials had been registered. ... pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of ... In September 2010 Roche halted Phase III clinical trials due to incidences of serious hypersensitivity …
Isoflavone
Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content is 1-2 mg/gram . The main soy isoflavones are mostly...
Experimental
Matched Description: … of soy products associated with a reduced incidences of coronary heart disease, atherosclerosis, type ... Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important ... Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content …
Avexitide
Avexitide is under investigation in clinical trial NCT02996812 (Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia).
Investigational
Matched Iupac: … methylpentanamido]-3-hydroxypropanamido]hexanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]butanoic acid …
Matched Description: … of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia). ... Avexitide is under investigation in clinical trial NCT02996812 (Evaluation of Single Ascending Doses …
Matched Description: … of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia). ... Avexitide is under investigation in clinical trial NCT02996812 (Evaluation of Single Ascending Doses …
Brimapitide
Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers).
Investigational
Matched Iupac: … carbamimidamido-1-oxopentan-2-yl]carbamoyl}-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}propanoic acid …
Matched Description: … iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers). ... Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single …
Matched Description: … iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers). ... Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single …
Brasofensine
Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of Parkinson's Disease. Phase I/II trials for brasofensine have been completed in the U.K. In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230.
Investigational
Matched Description: … Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of ... In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230 …
Triazavirin
Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain.[A191709,A191625,A191916] It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications. Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating...
Experimental
Tagatose
Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food additive as a low calorie sweetener. Additionally,...
Investigational
Matched Description: … commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of ... Additionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes. …
Leronlimab
Leronlimab, or PRO-140, is a human monoclonal antibody developed by CytoDyn. It was first described in the literature in 2001. This antibody binds to CCR5, which may be useful in treating HIV, cancers, and severely ill COVID-19 patients.[A192846,A192858,L12684]
Investigational
Bicifadine
Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain.
Investigational
Matched Description: … It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with ... to have potent analgesic activity in vivo and was chosen for further development for the treatment of …
D-JNKI-1
A synthetic, cell permeable peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of both the morphological integrity and physiological function of the organ of Corti during times of oxidative stress.
Investigational
Matched Iupac: … carbamimidamido-1-oxopentan-2-yl]carbamoyl}-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}propanoic acid …
Matched Description: … both the morphological integrity and physiological function of the organ of Corti during times of oxidative ... peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of …
Matched Description: … both the morphological integrity and physiological function of the organ of Corti during times of oxidative ... peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of …
Vanoxerine
Vanoxerine is a highly selective dopamine transporter antagonist. It was synthesized in the late 1970s and developed as a potential treatment for depression. Vanoxerine was later evaluated as a potential treatment for cocaine addiction due to its ability to block dopamine reuptake with a slower dissociation rate than cocaine. Although...
Investigational
Matched Description: … [A37914] Although several studies have suggested that the profile of vanoxerine is safer than that of …
Icaridin
Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of the piperidine chemical family. Piperidines are structural components of piperine, which is a plant extract from the genus _Piper _, or pepper. Icaridin has been commonly used as a topically-applied insect repellent...
Experimental
Matched Description: … It is considered to be the first choice of repellent by the Public Health Agency of Canada’s Canadian ... known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of ... Piperidines are structural components of [piperine], which is a plant extract from the genus _Piper _ …
Vatalanib
Vatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.
Investigational
Matched Description: … Vatalanib is under investigation for the treatment of solid tumors. …
(S)-camphor
(S)-camphor, or L(-)-Camphor, is a stereoisomer of DB01744, a bicyclic monoterpene known to potentiate both heat and cold sensations . (S)-camphor is not the naturally-occurring stereoisomer but displays similar TRPV channel affinity and current inhibition . DB01744 is isolated from the wood of the camphor laurel tree, Cinnamomum camphora, and...
Experimental
Matched Description: … history of medicinal use. ... (S)-camphor, or L(-)-Camphor, is a stereoisomer of [DB01744], a bicyclic monoterpene known to potentiate ... [DB01744] is isolated from the wood of the camphor laurel tree, _Cinnamomum camphora_, and had a long …
Brotizolam
Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. Brotizolam has similar effects to short-acting benzodiazepines such as triazolam. Brotizolam is indicated for 2-4 weeks of treatment for severe or debilitating insomnia. Brotizolam is an extremely potent...
Investigational
Withdrawn
Matched Description: … Brotizolam is indicated for 2-4 weeks of treatment for severe or debilitating insomnia. ... Brotizolam is an extremely potent drug and it is rapidly eliminated with an average half-life of 4.4 …
Fenproporex
Fenproporex is an orally active stimulant drug, which was developed in the 1960s. It is used as an appetite suppressant and a treatment for obesity. It is listed as an illicit substance in many countries due to addiction issues and listed as a prohibited substance by the World Anti-Doping Agency....
Experimental
Illicit
Withdrawn
Matched Description: … efficacy and safety data, and is listed as a drug in Schedule IV of the Controlled Substances Act. ... fenproporex (N-2-cyanoethylamphetamine) falls within the phenylethamine and amphetamine chemical class of ... Contrary to the claim, research has demonstrated easy in vivo cleavage of the N-2-cyanothyl substituent …
Voglibose
Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.
Investigational
Displaying drugs 10101 - 10125 of 12433 in total