Displaying drugs 10476 - 10500 of 14740 in total
Tirabrutinib
Tirabrutinib is under investigation in clinical trial NCT02626026 (Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)).
Investigational
Matched Description: … 4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)). ... Tirabrutinib is under investigation in clinical trial NCT02626026 (Safety and Pharmacokinetics of GS- …
Firsocostat
Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)).
Investigational
Matched Description: … Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy ... of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)). …
Aphidicolin
Aphidicolin is an antimitotic and antiviral metabolite of the mould Cephalosporium aphidicola. It inhibits DNA polymerase alpha and blocks DNA replication.[A259157, A259162]
Investigational
Matched Description: … It inhibits DNA polymerase alpha and blocks DNA replication.[A259157, A259162] ... Aphidicolin is an antimitotic and antiviral metabolite of the mould _Cephalosporium aphidicola_. …
ACR325
ACR325 is developed for the treatment of Parkinson’s disease and psychoses, including bipolar disorder, for which disease existing therapies have only limited effect and considerable adverse side effects. ACR325 is a dopaminergic stabiliser, which has demonstrated promising results in disease models for motor functions and psychoses.
Investigational
Matched Description: … ACR325 is developed for the treatment of Parkinson’s disease and psychoses, including bipolar disorder ... , for which disease existing therapies have only limited effect and considerable adverse side effects ... dopaminergic stabiliser, which has demonstrated promising results in disease models for motor functions and …
AS-8112
AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3. It has been shown to exert potent antiemetic effects in animal studies and has been investigated for potential medical use.
Experimental
Matched Description: … D3, and the serotonin receptor 5-HT3. ... 8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and ... It has been shown to exert potent antiemetic effects in animal studies and has been investigated for …
2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
Experimental
DSM-265
DSM265 has been used in trials studying the prevention and treatment of Malaria.
Investigational
Matched Description: … DSM265 has been used in trials studying the prevention and treatment of Malaria. …
Protocatechualdehyde
Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes...
Experimental
Matched Description: … cells and colorectal cancer cells by reducing the expression of pro-oncogenes β-catenin and cyclin D1 ... naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and ... Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer …
Cyclohexanol
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers. [PubChem]
Experimental
Matched Description: … They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and …
Liposomal prostaglandin E1
Liposome-encapsulated form of prostaglandin E1 (Liprostin) is known to be a potent vasodilator and platelet inhibitor as well as an anti-inflammatory and anti-thrombotic agent. The liposomal formulation of PGE-1 changes the drug’s dynamics and improve its therapeutic index in ways that PGE-1 alone could not achieve.
Investigational
Matched Description: … inhibitor as well as an anti-inflammatory and anti-thrombotic agent. ... Liposome-encapsulated form of prostaglandin E1 (Liprostin) is known to be a potent vasodilator and platelet ... The liposomal formulation of PGE-1 changes the drug’s dynamics and improve its therapeutic index in ways …
Umbilical Cord Blood Hematopoietic Stem Cells
The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive collection procedures, and more plasticity for multi-differentiation. UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have increased sensitivity to various factors, and are able to...
Investigational
Matched Description: … From the UCB, mononuclear cells are isolated and cultured in medium, expanded, and differentiated into ... of cytotoxicity and immunological reactions. ... are able to generate erythroid and myeloid progenitor colonies. …
HM-30181
Experimental
Burfiralimab
Burfiralimab is under investigation in clinical trial NCT06306339 (A Study to Assess the Efficacy and Safety of Burfiralimab (Hzvsf-v13) and DMRD (Disease-modifying Antirheumatic Drug)).
Investigational
Matched Description: … Safety of Burfiralimab (Hzvsf-v13) and DMRD (Disease-modifying Antirheumatic Drug)). ... Burfiralimab is under investigation in clinical trial NCT06306339 (A Study to Assess the Efficacy and …
C-1027 Aromatized chromophore
Experimental
Piritrexim
Piritrexim has been used in trials studying the treatment of Bladder Cancer, Urethral Cancer, and Transitional Cell Cancer of the Renal Pelvis and Ureter.
Investigational
Matched Description: … Cell Cancer of the Renal Pelvis and Ureter. ... Piritrexim has been used in trials studying the treatment of Bladder Cancer, Urethral Cancer, and Transitional …
Abediterol
Abediterol has been used in trials studying the treatment of Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Chronic Obstructive Pulmonary Disease (COPD) and Asthma.
Investigational
Matched Description: … Chronic Obstructive Pulmonary Disease (COPD) and Asthma. ... been used in trials studying the treatment of Asthma, Chronic Obstructive Pulmonary Disease (COPD), and …
AN2898
AN2898 is under investigation in clinical trial NCT01301508 (Efficacy and Safety of AN2898 and AN2728 Topical Ointments to Treat Mild-to-moderate Atopic Dermatitis).
Investigational
Matched Description: … AN2898 is under investigation in clinical trial NCT01301508 (Efficacy and Safety of AN2898 and AN2728 …
MK-1454
A synthetic cyclic dinucleotide (CDN) and agonist of stimulator of interferon genes protein (STING), with potential immunoactivating and antineoplastic activities. Upon intratumoral (IT) administration, STING agonist MK-1454 binds to STING and activates the STING pathway, which promotes IKK-related kinase TANK-binding kinase 1 (TBK1) signaling and activates nuclear factor-kappa B (NF-kB)...
Investigational
Matched Description: … with potential immunoactivating and antineoplastic activities. ... A synthetic cyclic dinucleotide (CDN) and agonist of stimulator of interferon genes protein (STING), ... This results in a CTL-mediated immune response against tumor cells and causes tumor cell lysis. …
Pyruvaldehyde
An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals. [PubChem]
Experimental
Matched Description: … cell preparations, in various culture media, and in vivo in certain animals. ... An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning ... It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated …
CX501
Cx501 is used to treat epidermolysis bullosa (EB), a rare genetic condition which can lead to contraction of the joints, fusion of fingers and toes, contraction of the mouth membranes and narrowing of the oesophagus. It is developed by Cellerix and is in phase I of clinical trials.
Investigational
Matched Description: … It is developed by Cellerix and is in phase I of clinical trials. ... toes, contraction of the mouth membranes and narrowing of the oesophagus. ... bullosa (EB), a rare genetic condition which can lead to contraction of the joints, fusion of fingers and …
Amido Phenyl Pyruvic Acid
Experimental
Displaying drugs 10476 - 10500 of 14740 in total